Cannabis use among older adults: Potential risks and benefits to an aging population

老年人吸食大麻：人口老龄化的潜在风险和益处

• 批准号: 10563144
• 负责人: Angela Bryan
• 金额: $ 60.85万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10563144
• 关键词: Accounting; Acute; Adult; Age; Aging; American; Anxiety; Applications Grants; Area; Behavioral; Benefits and Risks; Blood; Cannabidiol; Cannabinoids; Cannabis; Cannabis policy; Cannabis retail; Colorado; Control Groups; Data; Decision Aid; Decision Making; Elderly; Epidemiology; Exercise; Goals; Harm Reduction; Human; Laboratories; Legal; Life; Medical; Medical Marijuana; Mental Depression; Motor; Neurocognition; Neurocognitive; Older Population; Outcome; Pain; Participant; Patient Self-Report; Patients; Pharmacology; Physiology; Play; Population; Prevalence; Process; Public Health; Publishing; Qualitative Methods; Quality of life; Recreation; Reporting; Research; Research Infrastructure; Risk; Role; Schedule; Sleep; Sleeplessness; Surveys; Symptoms; Tetrahydrocannabinol; Time; Work; age group; aged; aging population; cognitive function; comparison group; design; epidemiologic data; experience; impression; innovation; interest; marijuana legalization; marijuana use; marijuana user; motor control; negative affect; patient oriented; pharmacologic; prospective; recruit; symptomatic improvement; virtual

Project Summary The population of older adults in the U.S. is increasing dramatically, doubling from 48 million to 88 million by the year 2050. As more Americans live longer, the challenge is to assure that quality of life is being maintained along with quantity of life. Research is beginning to focus on understanding the changing physiology underlying normal human aging, as well as expand on behavioral and pharmacological strategies that may assist older adults to maximize their later years, and recent surveys suggest that some may believe that legalized cannabis products have a role to play. Simultaneously, the increasing legalization and acceptance of cannabis is occurring at a rapid pace. Older adults are the fastest growing group of cannabis users in the U.S., with prevalence up by 250% for in some age groups, who perceive virtually no risk of using cannabis monthly (85.3%) or even weekly (79%). National Surveys also showed that older adults were more likely to use cannabis for medicinal purposes than for recreational purposes, and common reasons for use include pain, anxiety, depression, and insomnia. There are obvious and critical questions that this situation poses. First, do older adults experience relief from their symptoms and does this depend on the constituent cannabinoids of the product they are using? Second, are there impacts on neurocognition and motor control that might be harmful, or even potentially beneficial, and do these, too, depend on the cannabinoid profile of the products being used? Third, how can we assist older adults in decision-making regarding cannabis? The overarching goal of this grant application is to leverage our innovative mobile pharmacology laboratory approach and existing aging research infrastructure to better understand the effects of legal market cannabis in adults aged 60 and over. To that end, the proposed research will utilize a prospective, patient-centered observational design to recruit and assess older adults who are interested in using cannabis for pain, trouble sleeping, or negative affect and a comparison group who are not interested in cannabis use. Users will choose and use one of three types of edible cannabis products (i.e., a CBD dominant product, a THC+CBD product, or a THC dominant product) for a total of three months. The proposed research has three aims. First, we will explore the effects of edible cannabis of varying composition among older adults who desire to use cannabis to treat their pain, trouble sleeping, or negative affect (depression/anxiety) as compared to a non-sing comparison group assessed by changes in the Patient Global Impression of Change scale. Second we will explore the effects of edible cannabis use of varying composition on neurocognition and motor control both acutely and over time among older adults. Finally, we will examine the process by which older adult cannabis users decide what type of cannabis product they prefer. Pursuit of these aims has tremendous

项目摘要 美国的老年人口正在急剧增加，从4800万增加到8800万，翻了一番。 到2050年。随着越来越多的美国人活得更长，我们面临的挑战是确保生活质量 保持沿着生命的数量。研究开始关注于理解 生理学基础的正常人类衰老，以及扩大行为和药理学策略 这可能有助于老年人最大限度地提高他们的晚年，最近的调查表明，有些人可能认为， 合法化的大麻产品可以发挥作用。与此同时，越来越多的合法化和 对大麻的接受速度很快。老年人是大麻增长最快的群体 美国的用户，在一些年龄组中，患病率上升了250%，他们认为几乎没有使用风险 大麻每月（85.3%）或甚至每周（79%）。全国调查还显示， 可能将大麻用于医疗目的而不是娱乐目的，以及使用大麻的常见原因 包括疼痛、焦虑、抑郁和失眠。有明显和关键的问题，这种情况， 摆姿势。首先，老年人的症状是否得到缓解，这是否取决于成分 他们使用的产品的大麻素？第二，是否对神经认知和运动控制有影响 这可能是有害的，甚至可能是有益的，这些也取决于大麻素的分布。 正在使用的产品？第三，我们如何帮助老年人做出有关大麻的决策？ 这项拨款申请的首要目标是利用我们创新的移动的药理学实验室 方法和现有的老化研究基础设施，以更好地了解法律的市场大麻的影响， 60岁及以上的成年人。为此，拟议的研究将利用一个前瞻性的，以患者为中心的 观察性设计招募和评估有兴趣使用大麻治疗疼痛的老年人， 睡眠困难，或负面影响，以及对大麻使用不感兴趣的对照组。 用户将选择和使用三种类型的食用大麻产品之一（即，CBD主导产品， THC+CBD产品，或THC主导产品）共三个月。该研究计划有三个 目标。首先，我们将探讨不同成分的可食用大麻对老年人的影响， 使用大麻来治疗他们的疼痛，睡眠困难，或负面影响（抑郁/焦虑），与之相比， 通过患者总体印象变化量表的变化评估非singing对照组。二 我们将探讨不同成分的食用大麻对神经认知和运动控制的影响 对于老年人来说，无论是急性的还是随着时间的推移。最后，我们将研究老年人 大麻使用者决定他们喜欢哪种类型的大麻产品。追求这些目标具有巨大的