Exercise adherence and cognitive decline: Engaging with the Black community to develop and test a goal-setting and exercise intensity intervention

项目摘要 美国人口的平均年龄正在迅速增加，随之而来的是与年龄相关的 认知能力下降。此外，与年龄相关的认知能力下降的风险可能不成比例地影响 许多历史上代表不足的群体。有规律的体力活动(PA)与较低的患病风险相关 认知能力下降，但许多人很难长期保持PA。目标设定呈现一种 前景看好的途径有利于PA的维护，具有很强的公共卫生意义。同样，锻炼身体 强度可以推动这一目标，因为更高强度的PA的挑战性目标可能提供最健壮的PA 维修。然而，重要的是，大多数现有的关于目标设定、运动强度和理论的研究-- 总体上，在高SES、低多样性样本和现场中产生了基于运动的干预措施 在很大程度上忽视了这种差异，最近的审查和元分析甚至没有报告种族，民族， 或社会经济人口统计因素。尽管压迫制度和结构性种族主义无疑 影响健康行为和结果的差异，也有可能现有的个人水平理论- 基于文化的干预不适合许多社区，如非裔美国人和黑人 移民(即黑人社区)。在这项申请中，我们将采取社区参与的研究 定制和测试一种基于理论的干预方法，以促进遵守推荐的PA水平 黑人社区使用以人为中心的目标设定技术。我们将确定是否 不同PA强度的处方缓和了这些目标设定方法和测试的有效性 与这些干预措施对行为依从性的有效性相关的理论中介因素和 与认知衰退相关的生物标记物的健康变化。因此，这一计划的首要目标是 该项目将采用社区参与的研究方法来1)制定基于理论的目标设定 丹佛大都市区黑人社区的运动干预(R61)和2)利用 操作条件框架，以测试PA遵守的干预效果，每周 运动量，以及与认知衰退相关的生物标记物的变化(R33)。这些 目标将通过与我们的社区合作伙伴Gyedi Project进行合作来实现，以专注于并充分 让丹佛大都市区的黑人社区参与研究过程。

Project Summary The average age of the U.S. population is rapidly increasing and with it the prevalence of age-associated cognitive decline. Furthermore, the risk for age-associated cognitive decline may disproportionately affect many historically underrepresented groups. Regular physical activity (PA) is associated with lower risk for cognitive decline, but many people struggle to maintain PA over the long term. Goal setting presents one promising avenue to facilitate PA maintenance and has strong public health significance. Likewise, exercise intensity may further this aim as challenging goals for higher intensity PA may provide the most robust PA maintenance. Importantly, however, most existing research on goal setting, exercise intensity, and theory- based exercise interventions overall has been generated among high SES, low diversity samples, and the field has largely neglected this disparity, with recent reviews and meta-analyses failing to even report racial, ethnic, or socioeconomic demographic factors. While systems of oppression and structural racism undoubtedly influence disparities in health behavior and outcomes, it is also possible that existing individual-level theory- based interventions are not culturally appropriate for many communities, such as African Americans and Black immigrants (i.e., the Black community). In this application, we will take a community engaged research approach to tailor and test a theory-based intervention promoting adherence to recommended levels of PA in the Black community using the technique of person-centered goal setting. We will determine whether prescriptions of different PA intensities moderate the effectiveness of these goal-setting approaches and test the theoretical mediators associated with the effectiveness of these interventions on behavioral adherence and healthy changes in biomarkers associated with cognitive decline. Therefore, the overarching goals of this project are to take a community engaged research approach to 1) tailor a theory-based goal-setting exercise intervention in the Denver metropolitan area Black community (R61) and 2) utilize the Operating Conditions Framework to test the efficacy of the intervention for PA adherence, weekly volume of exercise, and changes in biomarkers associated with cognitive decline (R33). These objectives will be met through collaboration with our community partner The Gyedi Project to focus on and fully engage the Black community in the Denver metropolitan area in the research process.