Roadblocks in DNA replication

DNA复制的障碍

• 批准号: DP210100167
• 负责人: Prof Antoine van Oijen
• 金额: $ 42.23万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210100167
• 关键词: Roadblocks; DNA; replication

This project aims to develop the technology to visualise and understand the molecular processes responsible for the faithful copying of cellular DNA in the presence of roadblocks caused by chemical pressures and competing intracellular events. Understanding this process is important as DNA replication is responsible for copying the DNA genetic blueprint of cells and is crucial to all life on earth. This project will have as key outcomes the development of novel molecular visualisation technology and the first molecular description of the dynamic processes used by the DNA-replication machinery to navigate roadblocks. These outcomes should provide significant benefits including enhanced collaboration and scientific capacity in Australia.

该项目旨在开发技术，以可视化和理解负责在化学压力和竞争性细胞内事件造成的路障存在下忠实复制细胞DNA的分子过程。理解这一过程很重要，因为DNA复制负责复制细胞的DNA遗传蓝图，对地球上的所有生命都至关重要。该项目的主要成果将是开发新型分子可视化技术，并首次对DNA复制机器用于导航路障的动态过程进行分子描述。这些成果应能带来重大惠益，包括加强澳大利亚的合作和科学能力。