Acute Use of Alcohol and Attentional Bias towards Suicide: An Experimental Test of the Attention-Allocation Model.

急性酒精使用和自杀注意力偏差：注意力分配模型的实验测试。

• 批准号: 10349545
• 负责人: Caitlin W Clevenger
• 金额: $ 14.85万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-11 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10349545
• 关键词: Acute; Address; Adult; Affective; Aggressive behavior; Alcohol consumption; Alcoholic Beverages; Alcoholic Intoxication; Alcohols; Attention; Award; Behavioral; Beverages; Cessation of life; Clinical; Cognitive; Communities; Cues; Data; Development; Development Plans; Disinhibition; Distress; Emotional; Exhibits; Expectancy; Experimental Designs; Feeling suicidal; Future; Goals; Grant; Impulsivity; Individual; Individual Differences; Intervention; Intoxication; Investigation; Knowledge; Lead; Measures; Mental Health; Mentored Patient-Oriented Research Career Development Award; Mentorship; Modeling; Moods; Motivation; National Institute on Alcohol Abuse and Alcoholism; Outcome; Pain; Pain Threshold; Participant; Performance; Pilot Projects; Placebos; Play; Primary Prevention; Procedures; Psychologist; Publications; Research; Research Personnel; Resources; Risk; Role; Sampling; Serious Adverse Event; Stimulus; Suicide; Suicide attempt; Suicide prevention; Testing; Training; Work; Writing; alcohol comorbidity; alcohol consequences; alcohol effect; alcohol expectancy; alcohol involvement; alcohol use disorder; attentional bias; base; career; career development; design; experience; experimental study; feasibility testing; innovation; negative affect; negative mood; patient oriented research; performance based measurement; positive mood; recruit; research and development; skills; suicidal; suicidal behavior; suicidal morbidity; suicidal risk; theories

Project Summary/Abstract This K23 Mentored Patient-Oriented Research Career Development Award will facilitate my long-term career goal of conducting patient-oriented research on the behavioral and affective consequences of alcohol use and alcohol use disorders, namely the impact of acute use of alcohol (AUA) on suicidal ideation, attempts, and deaths. AUA is associated with markedly increased odds of a suicide attempt; however, the conditions under which AUA confers suicide risk are not well understood. In line with NIAAA’s strategic objective of identifying mechanisms underlying alcohol use disorder and co-occurring mental health conditions, this project will test the conditions under which AUA may increase suicide risk and elucidate targets for alcohol-related suicide prevention. I am a clinical psychologist with a strong background in research on the affective and behavioral consequences of alcohol use, including suicidal thoughts and behaviors. The proposed research and career development plan build directly on my prior experiences to provide greater knowledge and skills necessary to conduct innovative investigations of the mechanisms and conditions underlying the co-morbidity of alcohol use disorders with suicide. Guided by the attention allocation model, the proposed pilot study will explore the combined effects of AUA, mood, and alcohol expectancies on attentional bias towards suicide-related cues. Specific Aim 1 will test the feasibility of our experimental procedures. Specific Aim 2 will explore the combined impact of AUA and negative mood on attentional bias towards suicide in a sample of community adults. Specific Aim 3 will explore whether individual differences in alcohol expectancies influence these associations. I will conduct a 2 by 2 (alcohol/placebo by negative mood/positive mood), between-subjects experiment involving alcohol administration, a well-established mood induction paradigm, and a performance-based dependent measure of attention towards suicide-related cues. This award will enhance my career development to conduct this and future related studies through developing 1) expertise in the design and conduct of experiments that test the effects of AUA, alcohol expectancies, and mood states on suicide-related outcomes, 2) proficiency in the design and conduct of alcohol administration studies, 3) knowledge and experience in the use of performance-based measures of suicide risk, and 4) skills in mentorship, lab management, publication-writing, and grant-writing. My mentorship team is well-suited to facilitate the research and career development plans, with combined expertise in the behavioral and affective consequences of alcohol use, alcohol administration, and performance-based measures of suicide-related constructs.

项目概要/摘要 K23 指导的以患者为导向的研究职业发展奖将促进我的长期职业生涯 目标是对饮酒的行为和情感后果进行以患者为导向的研究， 酒精使用障碍，即急性饮酒 (AUA) 对自杀意念、企图和自杀的影响 死亡人数。 AUA 与自杀企图的几率显着增加有关；然而，条件下 哪种 AUA 会带来自杀风险尚不清楚。符合 NIAAA 的战略目标： 酒精使用障碍和同时发生的心理健康状况的潜在机制，该项目将测试 AUA 可能会增加自杀风险的条件并阐明与酒精相关的自杀目标 预防。我是一名临床心理学家，在情感和行为研究方面拥有深厚的背景 饮酒的后果，包括自杀想法和行为。拟议的研究和职业 发展计划直接建立在我之前的经验之上，以提供更多必要的知识和技能 对酒精使用共病的机制和条件进行创新研究 与自杀有关的疾病。在注意力分配模型的指导下，拟议的试点研究将探索 AUA、情绪和酒精预期对自杀相关线索的注意力偏差的综合影响。 具体目标 1 将测试我们实验程序的可行性。具体目标 2 将探索组合 AUA 和负面情绪对社区成年人样本中自杀注意力偏差的影响。具体的 目标 3 将探讨酒精预期的个体差异是否会影响这些关联。我会 进行 2 x 2（酒精/安慰剂按消极情绪/积极情绪）受试者间实验，涉及 酒精管理、完善的情绪诱导范式和基于表现的依赖 对自杀相关线索的关注程度。该奖项将促进我的职业发展 本研究和未来的相关研究通过开发 1) 设计和进行实验的专业知识 测试 AUA、酒精预期和情绪状态对自杀相关结果的影响，2) 熟练程度 酒精管理研究的设计和实施，3) 使用酒精的知识和经验 基于绩效的自杀风险衡量标准，以及 4) 指导、实验室管理、出版物写作、 和拨款写作。我的导师团队非常适合促进研究和职业发展计划， 结合酒精使用、酒精管理的行为和情感后果方面的专业知识， 以及基于表现的自杀相关结构测量。