Acute Use of Alcohol and Attentional Bias towards Suicide: An Experimental Test of the Attention-Allocation Model.

项目摘要/摘要 这项K23指导患者导向研究职业发展奖将促进我的长期职业生涯 以病人为中心，研究饮酒对行为和情感的影响 酒精使用障碍，即急性酒精使用(AUA)对自杀意念、企图和 死亡。AUA与自杀未遂的几率显著增加有关；然而，在 AUA赋予自杀风险的哪些因素尚不清楚。与NIAAA确定的战略目标一致 酒精使用障碍和共生精神健康状况的潜在机制，该项目将测试 AUA可能增加自杀风险并阐明酒精相关自杀目标的条件 预防。我是一名临床心理学家，在情感和行为研究方面有很强的背景 饮酒的后果，包括自杀念头和行为。拟议的研究和职业 发展计划直接建立在我以前的经验基础上，以提供必要的更多知识和技能 对酒精使用并存的机制和条件进行创新性的调查 自杀性精神障碍。在注意力分配模式的指引下，拟议的先导研究将探讨 AUA、情绪和酒精预期对自杀相关线索的注意偏向的综合影响。 具体目标1将测试我们实验程序的可行性。《特定目标2》将探索组合 AUA和消极情绪对社区成年人自杀注意偏向的影响。特定的 目标3将探索酒精预期的个体差异是否会影响这些联系。这就做 进行2×2(酒精/安慰剂/消极情绪/积极情绪)的受试者间实验，包括 饮酒，一种成熟的情绪诱导范式，以及基于表现的依赖 衡量人们对自杀相关线索的关注程度。这个奖项将加强我的职业发展，以进行 这项研究和未来的相关研究通过发展1)在设计和进行实验方面的专业知识， 测试AUA、酒精预期和情绪状态对自杀相关结果的影响，2)熟练使用 设计和实施酒精管理研究，3)使用酒精的知识和经验 基于绩效的自杀风险测量，以及4)指导、实验室管理、出版物写作、 以及拨款申请。我的导师团队非常适合促进研究和职业发展计划， 在酒精使用的行为和情感后果方面拥有综合专业知识， 以及基于表现的自杀相关结构的测量。

Project Summary/Abstract This K23 Mentored Patient-Oriented Research Career Development Award will facilitate my long-term career goal of conducting patient-oriented research on the behavioral and affective consequences of alcohol use and alcohol use disorders, namely the impact of acute use of alcohol (AUA) on suicidal ideation, attempts, and deaths. AUA is associated with markedly increased odds of a suicide attempt; however, the conditions under which AUA confers suicide risk are not well understood. In line with NIAAA’s strategic objective of identifying mechanisms underlying alcohol use disorder and co-occurring mental health conditions, this project will test the conditions under which AUA may increase suicide risk and elucidate targets for alcohol-related suicide prevention. I am a clinical psychologist with a strong background in research on the affective and behavioral consequences of alcohol use, including suicidal thoughts and behaviors. The proposed research and career development plan build directly on my prior experiences to provide greater knowledge and skills necessary to conduct innovative investigations of the mechanisms and conditions underlying the co-morbidity of alcohol use disorders with suicide. Guided by the attention allocation model, the proposed pilot study will explore the combined effects of AUA, mood, and alcohol expectancies on attentional bias towards suicide-related cues. Specific Aim 1 will test the feasibility of our experimental procedures. Specific Aim 2 will explore the combined impact of AUA and negative mood on attentional bias towards suicide in a sample of community adults. Specific Aim 3 will explore whether individual differences in alcohol expectancies influence these associations. I will conduct a 2 by 2 (alcohol/placebo by negative mood/positive mood), between-subjects experiment involving alcohol administration, a well-established mood induction paradigm, and a performance-based dependent measure of attention towards suicide-related cues. This award will enhance my career development to conduct this and future related studies through developing 1) expertise in the design and conduct of experiments that test the effects of AUA, alcohol expectancies, and mood states on suicide-related outcomes, 2) proficiency in the design and conduct of alcohol administration studies, 3) knowledge and experience in the use of performance-based measures of suicide risk, and 4) skills in mentorship, lab management, publication-writing, and grant-writing. My mentorship team is well-suited to facilitate the research and career development plans, with combined expertise in the behavioral and affective consequences of alcohol use, alcohol administration, and performance-based measures of suicide-related constructs.