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Arthritis and Autoimmune Disease Epidemiology and Impact in the Alaska Native Population

关节炎和自身免疫性疾病的流行病学及其对阿拉斯加原住民的影响

基本信息

批准号：
10348729
负责人：
Elizabeth D Ferucci
金额：
$ 26.96万
依托单位：
ALASKA NATIVE TRIBAL HEALTH CONSORTIUM
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-05 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10348729
关键词：
Address Age Alaska Alaska Native American Indians Arthritis Autoimmune Diseases Black race Chronic Disease Connective Tissue Diseases Data Data Reporting Data Set Data Sources Degenerative polyarthritis Electronic Health Record Epidemiology Gender Gout Health Health care facility Hip region structure Hospitalization Hospitals Individual Investigation Knee Literature Lupus Medical Records Medical center Methods Morbidity - disease rate Musculoskeletal Diseases Native-Born Outcome Patient Self-Report Patients Physicians Population Prevalence Psoriatic Arthritis Replacement Arthroplasty Research Research Personnel Research Priority Rheumatoid Arthritis Site Source Spondylarthritis United States Validation Vasculitis base disability economic impact expectation health care service organization health data health disparity health organization hospitalization rates improved outcome neglect population based programs public health priorities tribal health tribal organization

项目摘要

PROJECT SUMMARY / ABSTRACT Arthritis and autoimmune diseases are a major cause of morbidity in the United States. Health disparities have been identified, with higher rates of many of these conditions in American Indian and Alaska Native (AI/AN) populations. Studies of individual forms of arthritis and autoimmune diseases have found high rates of rheumatoid arthritis, lupus, and spondyloarthritis in AI/AN populations. However, these conditions are often neglected as a public health or research priority and some, including osteoarthritis and psoriatic arthritis, have not been studied. Individuals with arthritis or autoimmune diseases are more likely to be hospitalized, and disparities in hospitalization rates have been described in other indigenous populations. Multiple studies in the United States have found disparities in total joint replacement rates in Black vs. White individuals with arthritis, but almost all studies of these disparities exclude the AI/AN population. A systematic population-based investigation of the prevalence, hospitalization rates and outcomes of arthritis and autoimmune diseases, and joint replacement disparities in AI/AN populations is warranted and would add significantly to the literature. To address this understudied health disparity, we propose the following Specific Aims: 1) Determine the prevalence of specific forms of arthritis and autoimmune disease in Alaska Native people statewide; 2) Determine the hospitalization rates and causes of hospitalization for AI/AN compared to non-AI/AN individuals in Alaska with arthritis and autoimmune diseases; and 3) Determine the rate of joint replacements (total knee and total hip) for AI/AN compared to non-AI/AN individuals statewide. It is our expectation, based on available data in AI/AN and other populations, that we will find high rates of most forms of arthritis or autoimmune disease in the Alaska Native population, high hospitalization rates, and low rates of joint replacements. This study is a unique partnership between a researcher in a tribal health organization and the organization's tribal epidemiology center that will leverage existing datasets to address understudied and significant health conditions in the Alaska Native population. We expect this study to add significantly to the literature on health disparities in arthritis and autoimmune diseases.

项目总结/摘要关节炎和自身免疫性疾病是美国发病的主要原因。健康已经确定了差异，其中许多疾病在美洲印第安人和阿拉斯加原住民（Alaska Native，AI/AN）关节炎和自身免疫性疾病的个体形式研究发现AI/AN人群中类风湿性关节炎、狼疮和脊柱关节炎的发病率很高。然而，这些条件往往被忽视为公共卫生或研究的优先事项，包括骨关节炎和银屑病关节炎。患有关节炎或自身免疫性疾病更有可能住院，住院率的差异在其他原住民中也有描述。美国的多项研究发现，黑人与白色关节炎患者的全关节置换率存在差异，但几乎所有这些差异的研究排除了AI/AN人群。一项系统的人口调查关节炎和自身免疫性疾病的患病率、住院率和结局，以及关节炎的 AI/AN人群的替代差异是有道理的，并将显著增加文献。为了解决这一研究不足的健康差距，我们提出了以下具体目标：1）确定阿拉斯加州土著居民中特定形式的关节炎和自身免疫性疾病的患病率; 2）确定与非AI/AN相比，AI/AN的住院率和住院原因阿拉斯加患有关节炎和自身免疫性疾病的个体;以及3）确定关节炎的发生率。与全州范围内的非AI/AN个体相比，AI/AN的置换（全膝关节和全髋关节）。是我们根据AI/AN和其他人群的现有数据，我们预计，阿拉斯加原住民的关节炎或自身免疫性疾病，高住院率，关节置换率低。这项研究是一个独特的伙伴关系之间的研究人员在部落卫生组织和该组织的部落流行病学中心，将利用现有的数据集以解决阿拉斯加原住民人口中研究不足和严重的健康状况。我们预计这项研究为关节炎和自身免疫性疾病的健康差异的文献增加了显著的内容。