Arthritis and Autoimmune Disease Epidemiology and Impact in the Alaska Native Population

项目摘要/摘要 关节炎和自身免疫性疾病是美国发病率的主要原因。健康状况 差异已经被发现，许多这些情况在美国印第安人和 阿拉斯加原住民(AI/AN)人口。个体形式的关节炎和自身免疫性疾病的研究 在AI/AN人群中发现类风湿性关节炎、狼疮和脊柱性关节炎的高发病率。 然而，作为公共卫生或研究的优先事项，这些情况往往被忽视， 包括骨性关节炎和牛皮癣关节炎，还没有研究过。患有关节炎或 自身免疫性疾病更有可能住院治疗，住院率的差异 在其他土著人口中也有描述。美国的多项研究发现 黑人和白人关节炎患者总关节置换率的差异，但几乎所有 对这些差异的研究排除了人工智能/AN人群。一项系统的人口调查 关节炎和自身免疫性疾病的患病率、住院率和结果，以及关节 人工智能/人工智能人群中的替换差异是合理的，并将显著增加文献。 为了解决这种未得到充分研究的健康差距，我们提出了以下具体目标：1)确定 全州阿拉斯加原住民中特定形式的关节炎和自身免疫性疾病的流行率；2) 确定AI/AN与非AI/AN的住院率和住院原因 阿拉斯加患有关节炎和自身免疫性疾病的个体；以及3)确定关节患病率 AI/AN的置换(全膝关节和全髋关节)与全州范围内的非AI/AN个体相比。这是我们的 基于人工智能/人工智能和其他人群的现有数据，我们将发现大多数 阿拉斯加原住民中关节炎或自身免疫性疾病的形式，高住院率，以及 关节置换率低。这项研究是部落研究人员之间独特的合作伙伴关系 卫生组织和该组织的部落流行病学中心将利用现有的数据集 以解决阿拉斯加土著人口中未得到充分研究的重大健康问题。我们预计 这项研究将显著增加有关关节炎和自身免疫性疾病的健康差异的文献。

PROJECT SUMMARY / ABSTRACT Arthritis and autoimmune diseases are a major cause of morbidity in the United States. Health disparities have been identified, with higher rates of many of these conditions in American Indian and Alaska Native (AI/AN) populations. Studies of individual forms of arthritis and autoimmune diseases have found high rates of rheumatoid arthritis, lupus, and spondyloarthritis in AI/AN populations. However, these conditions are often neglected as a public health or research priority and some, including osteoarthritis and psoriatic arthritis, have not been studied. Individuals with arthritis or autoimmune diseases are more likely to be hospitalized, and disparities in hospitalization rates have been described in other indigenous populations. Multiple studies in the United States have found disparities in total joint replacement rates in Black vs. White individuals with arthritis, but almost all studies of these disparities exclude the AI/AN population. A systematic population-based investigation of the prevalence, hospitalization rates and outcomes of arthritis and autoimmune diseases, and joint replacement disparities in AI/AN populations is warranted and would add significantly to the literature. To address this understudied health disparity, we propose the following Specific Aims: 1) Determine the prevalence of specific forms of arthritis and autoimmune disease in Alaska Native people statewide; 2) Determine the hospitalization rates and causes of hospitalization for AI/AN compared to non-AI/AN individuals in Alaska with arthritis and autoimmune diseases; and 3) Determine the rate of joint replacements (total knee and total hip) for AI/AN compared to non-AI/AN individuals statewide. It is our expectation, based on available data in AI/AN and other populations, that we will find high rates of most forms of arthritis or autoimmune disease in the Alaska Native population, high hospitalization rates, and low rates of joint replacements. This study is a unique partnership between a researcher in a tribal health organization and the organization's tribal epidemiology center that will leverage existing datasets to address understudied and significant health conditions in the Alaska Native population. We expect this study to add significantly to the literature on health disparities in arthritis and autoimmune diseases.