Administrative and Biostatistics

行政和生物统计学

• 批准号: 10349481
• 负责人: Sundeep Khosla
• 金额: $ 23.9万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10349481
• 关键词: Address; Advisory Committees; Age; Aging; Applications Grants; Bioinformatics; Biological; Biology; Biology of Aging; Biometry; Biostatistics Core; Cell Aging; Clinic; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Databases; Disease; Extramural Activities; Foundations; Functional disorder; Funding; Genetic; Geroscience; Goals; Grant; Histology; Individual; Infrastructure; Intervention; Investments; Leadership; Mediating; Metabolic dysfunction; Metabolism; Modeling; Mus; Muscle; Pathology; Pharmacology; Phenotype; Physiological; Physiology; Positioning Attribute; Principal Investigator; Program Research Project Grants; Progress Reports; Publications; Research; Research Personnel; Research Proposals; Resource Sharing; Resources; Sampling; Science; Site; Structure; System; Systems Biology; Therapeutic; Tissues; Translational Research; Translations; Vascular Diseases; aging population; analytical tool; bioinformatics resource; bone; bone metabolism; cellular targeting; clinical center; data dissemination; data sharing; design; drug development; drug discovery; experimental study; first-in-human; frailty; healthspan; meetings; member; mouse model; multidisciplinary; novel; prevent; programs; senescence; skeletal; skeletal muscle wasting; synergism; tool

CORE A: ADMINISTRATIVE AND BIOSTATISTICS CORE - PROJECT SUMMARY Khosla/Kirkland The Administrative and Biostatistics Core (Core A) will provide the overall leadership as well as the infrastructure for the Program Project Grant (PPG). The four Projects in this PPG application represent independent but highly interactive research proposals by investigators who have an established track record of collaborative studies. Core A will be responsible for the overall coordination of activities across all Projects and Cores, which will be accomplished in the context of three Specific Aims. Aim 1 is to provide the administrative leadership necessary for the PPG. The Core will house the PPG Executive Committee, have responsibility for fiscal management of the PPG as a whole, prepare progress reports and interact with NIA program officers, coordinate the dissemination of data through participation in scientific meetings and publications, and organize programmatic meetings, including those of the Internal and External Advisory Committees. Aim 2 is to provide the biostatistical and bioinformatics resources for the design and analysis of the studies. The statistical team of Dr. Therneau and Ms. Atkinson will provide the full spectrum of biostatistical and bioinformatic support for the design and analysis of the experiments proposed in each of the Projects. Aim 3 will optimize syngergies, use of common models, data and resource sharing, and scientific integration across Projects and Cores. Core A will implement and maintain a novel Mouse Cloud Database, which will be a key tool to optimizing the sharing of mice and biological samples from the mice across Projects and indeed, with other investigators at Mayo and extramurally. This will facilitate a systems biology approach to the study of aging and senescence and greatly facilitate data sharing among program members. Thus, a crucial function of the Core is integration at multiple levels – specifically, integration of tools and resources, and perhaps most importantly, scientific integration. Given the multi-disciplinary team of investigators and the focus of each team on a different tissue or physiological function (i.e., metabolism, bone, vasculature, muscle dysfunction/frailty), this application provides a unique opportunity in integrative physiology in the context of senescence and aging. In particular, we will be able to address key questions related to cross-talk between tissues and systemic effects of given changes in a particular tissue, and this scientific integration across tissues will be overseen by the Administrative and Biostatistics Core.

核心A：行政和生物统计核心--科斯拉/柯克兰项目摘要 行政和生物统计核心(核心A)将提供全面领导以及 计划项目赠款(PPG)的基础设施。此PPG应用程序中的四个项目代表 由调查人员提出的独立但高度互动的研究建议，他们有既定的记录 合作研究。核心A将负责所有项目活动的全面协调和 这将在三个具体目标的背景下实现。目标1是提供管理性的 对于PPG来说，领导是必要的。核心将容纳PPG执行委员会，负责 作为PPG的整体财务管理，准备进度报告，并与NIA项目官员互动， 通过参加科学会议和出版物协调数据传播，并组织 方案会议，包括内部和外部咨询委员会的会议。目标2是提供 用于设计和分析研究的生物统计学和生物信息学资源。的统计团队 Therneau博士和Atkinson女士将提供全方位的生物统计和生物信息学支持 设计和分析每个项目中提出的实验。Aim 3将优化语法，使用 共同模式、数据和资源共享以及跨项目和核心的科学整合。核心A 将实施和维护一个新的鼠标云数据库，这将是优化共享的关键工具 不同项目的小鼠和来自小鼠的生物样本，实际上，与Mayo和 从外到外。这将有助于用系统生物学的方法来研究衰老和衰老，并大大 促进计划成员之间的数据共享。因此，核心的一个关键功能是在多个 各级--具体地说，是工具和资源的整合，或许最重要的是科学整合。 鉴于调查人员的多学科团队以及每个团队的重点是不同的组织或 生理功能(即新陈代谢、骨骼、血管、肌肉功能障碍/脆弱)，该应用程序提供 在衰老和衰老的背景下，综合生理学的一个独特机会。特别是，我们将会 能够解决与组织之间的串扰和给定变化的系统影响相关的关键问题 特定的组织，这种跨组织的科学整合将由行政和 生物统计学核心。