The role of insufficient sleep and depression on hippocampal-dependent memory trajectories across the adolescent transition

睡眠不足和抑郁对青少年过渡期间海马依赖性记忆轨迹的作用

• 批准号: 10350390
• 负责人: Katharine Simon
• 金额: $ 15.96万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-07 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10350390
• 关键词: 12 year old; Address; Adolescence; Adolescent; Affect; Age; Attention; Beds; Brain; Childhood; Circadian Rhythms; Clinical; Clinical Psychology; Clinical assessments; Cognition; Cognitive; Data; Depressed mood; Development; Disease; Doctor of Philosophy; Early Diagnosis; Ecological momentary assessment; Equation; Evaluation; Future; Goals; Growth; Hippocampus (Brain); Individual; Intervention; K-Series Research Career Programs; Knowledge; Lead; Measurement; Measures; Mediation; Memory; Memory impairment; Mental Depression; Mental Health; Mentors; Methods; Mobile Health Application; Modeling; Neurocognitive; Outcome; Participant; Pediatric Research; Performance; Population; Psychopathology; Public Health; Reporting; Research; Research Domain Criteria; Risk; Risk Factors; Role; Sampling; Scientist; Sleep; Sleep Architecture; Sleep Deprivation; Symptoms; Testing; Time; Training; United States; Youth; base; career; child depression; clinical investigation; cognitive neuroscience; cognitive testing; depressive symptoms; design; diaries; early onset; longitudinal design; mHealth; multilevel analysis; novel; poor sleep; preadolescence; prospective; psychologic; recruit; remote grading; single episode major depressive disorder; skills; sleep onset; sleep pattern; social relationships; spatial memory; translational scientist; wearable device

Project Summary This K08 proposal will address a critical gap in our fundamental knowledge of the effects of insufficient sleep and depression on longitudinal sleep-dependent memory development and will prepare this applicant, Katharine Simon, PhD, to become an independent translational investigator with expertise in sleep, memory, and psychopathology across development. Depression in adolescence is a growing public health concern, with symptoms beginning during the transition to adolescence (9 -12 years)1 and conferring heightened risk for long-term deleterious psychological and cognitive outcomes.20-21 In contrast to other clinical disorders, depression is associated with specific deficits in hippocampal-dependent (HcDep) memory (e.g., declarative memory).9-11 Although the brain mechanisms underlying depression-related memory deficits are not understood, one potential risk factor may be insufficient sleep (e.g., short sleep duration, variable timing, or poor quality) given the critical role of sleep in supporting new hippocampal-dependent memory formation (sleep dependent memory [Hc-SDM]).12 The transition to adolescence is a particularly vulnerable time that involves increasingly dramatic changes to sleep patterns.2,3 Although a few nights of insufficient sleep does not consistently affect HcDep memory performance in adolescents18,50-53; typical insufficient weekly sleep is associated with reduced hippocampal volume.19 At present, it is clear there is a fundamental gap in our knowledge of the individual trajectories of insufficient sleep, depression, and Hc-SDM across the adolescent transition and the longitudinal associations between these factors. To address this question, 27 pre-adolescents (9 to 12 years) will be assessed using a repeated measurement-burst design with sampling at quarterly intervals over a year using a personalized, mobile health (mHealth) platform. At each quarterly evaluation, for 7 consecutive days, participants will complete daily sleep diaries, ecological momentary assessments, and Hc-SDM tasks. The hypothesize is that insufficient sleep and depression symptoms across the adolescent transition will predict long-term Hc-SDM performance trajectory deficits. This Mentored Clinical Scientist Research Career Development Award will support Dr. Simon’s training goals to acquire skills and knowledge in 1) gaining expertise in naturalistic, longitudinal cognitive and clinical assessment using mHealth and wearable devices, 2) training in clinical pediatric research, and 3) intensive repeated-measure analyses. These training aims will build on Dr. Simon’s prior training in cognitive neuroscience and clinical psychology and expertise in short-term experimental sleep-dependent memory research. Furthermore, the training Dr. Simon will gain from this K08 is an essential step to become an independent developmental translational researcher and will directly lead to my future R01 application to further evaluate the longitudinal trajectories of insufficient sleep and depressive symptoms on older adolescents’ Hc-SDM memory and identify key windows in which sleep-based interventions can support cognitive trajectories in depressed adolescents.

项目摘要 这项K08建议将解决我们对睡眠不足的影响的基本知识中的一个关键缺口 和抑郁对纵向睡眠依赖记忆发育的影响，并将为这位申请者做好准备， 凯瑟琳·西蒙博士，成为一名独立的翻译调查员，拥有睡眠、记忆、 以及整个发育过程中的精神病理学。青春期抑郁症是一个日益严重的公共卫生问题， 在过渡到青春期(9-12岁)期间开始的症状1，并增加了罹患 长期有害的心理和认知结果。20-21与其他临床障碍形成对比， 抑郁症与特定的海马体依赖(HcDep)记忆缺陷有关(例如，陈述性 记忆).9-11尽管抑郁症相关记忆缺陷的大脑机制不是 可以理解，一个潜在的风险因素可能是睡眠不足(例如，睡眠持续时间短、时间可变或 质量差)，因为睡眠在支持新的海马体依赖的记忆形成中起着关键作用 (睡眠依赖记忆[HC-SDM])12过渡到青春期是一个特别脆弱的时期， 睡眠模式发生了越来越大的变化。2，3尽管几个晚上的睡眠不足不会 持续影响18、50-53岁青少年的HcDep记忆表现；典型的每周睡眠不足是 与海马体体积减少有关。19目前，很明显，我们的 对睡眠不足、抑郁和HC-SDM的个体轨迹的了解 青春期转变以及这些因素之间的纵向关联。为了解决这个问题， 27名青春期前儿童(9至12岁)将使用带抽样的重复测量-突发设计进行评估 使用个性化的移动健康(MHealth)平台，在一年内每季度一次。每季度 评估，连续7天，参与者将完成每日睡眠日记，生态瞬间 评估和HC-SDM任务。假设是睡眠不足和抑郁症状 青春期过渡期将预测长期的HC-SDM表现轨迹缺陷。这是对临床的指导 科学家研究职业发展奖将支持西蒙博士的培训目标，以获得技能和 1)使用mHealth获得自然、纵向认知和临床评估方面的专业知识 和可穿戴设备，2)临床儿科研究培训，3)密集的重复测量分析。 这些培训目标将建立在西蒙博士之前接受的认知神经科学和临床心理学培训的基础上 以及短期实验性睡眠依赖记忆研究方面的专业知识。此外，培训的博士。 西蒙将从中获益K08是成为独立开发翻译的关键一步 研究人员，并将直接导致我未来的R01应用程序，以进一步评估 睡眠不足和抑郁症状对大龄青少年HC-SDM记忆的影响及识别关键窗口 其中，基于睡眠的干预可以支持抑郁青少年的认知轨迹。