The role of insufficient sleep and depression on hippocampal-dependent memory trajectories across the adolescent transition

睡眠不足和抑郁对青少年过渡期间海马依赖性记忆轨迹的作用

• 批准号: 10678631
• 负责人: Katharine Simon
• 金额: $ 15.96万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-07 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10678631
• 关键词: 12 year old; Acceleration; Address; Adolescence; Adolescent; Affect; Age; Attention; Beds; Brain; Childhood; Circadian Rhythms; Clinical; Clinical Psychology; Clinical assessments; Cognition; Cognitive; Data; Depressed mood; Development; Disease; Doctor of Philosophy; Early Diagnosis; Ecological momentary assessment; Equation; Evaluation; Future; Goals; Growth; Hippocampus; Individual; Intervention; K-Series Research Career Programs; Knowledge; Measurement; Measures; Mediation; Memory; Memory impairment; Mental Depression; Mental Health; Mentors; Methods; Mobile Health Application; Modeling; Neurocognitive; Outcome; Participant; Pediatric Research; Performance; Population; Psychopathology; Public Health; Reporting; Research; Research Domain Criteria; Risk; Risk Factors; Role; Sampling; Scientist; Sleep; Sleep Architecture; Sleep Deprivation; Symptoms; Testing; Time; Training; United States; Youth; career; child depression; clinical investigation; cognitive neuroscience; cognitive testing; depressive symptoms; design; diaries; early onset; human old age (65+); longitudinal design; mHealth; multilevel analysis; novel; poor sleep; preadolescence; prospective; psychologic; recruit; remote grading; single episode major depressive disorder; skill acquisition; sleep onset; sleep pattern; social relationships; spatial memory; translational scientist; verbal; wearable device

Project Summary This K08 proposal will address a critical gap in our fundamental knowledge of the effects of insufficient sleep and depression on longitudinal sleep-dependent memory development and will prepare this applicant, Katharine Simon, PhD, to become an independent translational investigator with expertise in sleep, memory, and psychopathology across development. Depression in adolescence is a growing public health concern, with symptoms beginning during the transition to adolescence (9 -12 years)1 and conferring heightened risk for long-term deleterious psychological and cognitive outcomes.20-21 In contrast to other clinical disorders, depression is associated with specific deficits in hippocampal-dependent (HcDep) memory (e.g., declarative memory).9-11 Although the brain mechanisms underlying depression-related memory deficits are not understood, one potential risk factor may be insufficient sleep (e.g., short sleep duration, variable timing, or poor quality) given the critical role of sleep in supporting new hippocampal-dependent memory formation (sleep dependent memory [Hc-SDM]).12 The transition to adolescence is a particularly vulnerable time that involves increasingly dramatic changes to sleep patterns.2,3 Although a few nights of insufficient sleep does not consistently affect HcDep memory performance in adolescents18,50-53; typical insufficient weekly sleep is associated with reduced hippocampal volume.19 At present, it is clear there is a fundamental gap in our knowledge of the individual trajectories of insufficient sleep, depression, and Hc-SDM across the adolescent transition and the longitudinal associations between these factors. To address this question, 27 pre-adolescents (9 to 12 years) will be assessed using a repeated measurement-burst design with sampling at quarterly intervals over a year using a personalized, mobile health (mHealth) platform. At each quarterly evaluation, for 7 consecutive days, participants will complete daily sleep diaries, ecological momentary assessments, and Hc-SDM tasks. The hypothesize is that insufficient sleep and depression symptoms across the adolescent transition will predict long-term Hc-SDM performance trajectory deficits. This Mentored Clinical Scientist Research Career Development Award will support Dr. Simon’s training goals to acquire skills and knowledge in 1) gaining expertise in naturalistic, longitudinal cognitive and clinical assessment using mHealth and wearable devices, 2) training in clinical pediatric research, and 3) intensive repeated-measure analyses. These training aims will build on Dr. Simon’s prior training in cognitive neuroscience and clinical psychology and expertise in short-term experimental sleep-dependent memory research. Furthermore, the training Dr. Simon will gain from this K08 is an essential step to become an independent developmental translational researcher and will directly lead to my future R01 application to further evaluate the longitudinal trajectories of insufficient sleep and depressive symptoms on older adolescents’ Hc-SDM memory and identify key windows in which sleep-based interventions can support cognitive trajectories in depressed adolescents.

项目摘要 这个K 08提案将解决我们对睡眠不足影响的基本知识中的一个关键空白 和抑郁症对纵向睡眠依赖性记忆发展的影响，并将使本申请人， 凯瑟琳西蒙，博士，成为一个独立的翻译研究与睡眠，记忆， 和精神病理学之间的联系青春期抑郁症是一个日益严重的公共卫生问题， 在向青春期过渡期间开始出现的症状（9 - 12岁）1， 长期有害的心理和认知结果。20 -21与其他临床疾病相反， 抑郁症与特定的海马依赖性（HcDep）记忆缺陷有关（例如，声明性 9 -11虽然抑郁症相关记忆缺陷的大脑机制并不 可以理解，一个潜在的风险因素可能是睡眠不足（例如，短睡眠持续时间、可变定时，或 质量差），因为睡眠在支持新的大脑皮层依赖性记忆形成中起着关键作用 （睡眠依赖记忆[Hc-SDM]）。12向青春期的过渡是一个特别脆弱的时期， 睡眠模式会发生越来越大的变化。2，3尽管几个晚上的睡眠不足不会 持续影响HcDep记忆性能的百分之18，50-53;典型的每周睡眠不足， 与海马体积减少有关。19目前，很明显，在我们的研究中存在着根本性的差距。 了解睡眠不足、抑郁和Hc-SDM的个体轨迹， 青少年的过渡和这些因素之间的纵向关联。为了解决这个问题， 将使用重复测量-突发设计和抽样评估27名青少年前期（9至12岁） 使用个性化的移动的健康（mHealth）平台，每季度一次，为期一年。每季度 评估，连续7天，参与者将完成每天的睡眠日记，生态瞬间 评估和Hc-SDM任务。假设睡眠不足和抑郁症状 青少年过渡期将预测长期Hc-SDM性能轨迹缺陷。本指导临床 科学家研究职业发展奖将支持西蒙博士的培训目标，以获得技能， 知识1）获得专业知识的自然，纵向认知和临床评估使用mHealth 和可穿戴设备，2）临床儿科研究培训，以及3）密集的重复测量分析。 这些培训目标将建立在西蒙博士先前在认知神经科学和临床心理学方面的培训基础上 以及短期实验性睡眠依赖记忆研究的专业知识。此外，训练博士。 西蒙将从中获得K 08是成为一个独立的发展翻译的重要一步 研究人员，并将直接导致我未来的R 01应用程序，以进一步评估纵向轨迹的 睡眠不足和抑郁症状对老年青少年Hc-SDM记忆和关键窗口识别的影响 其中基于睡眠的干预可以支持抑郁青少年的认知轨迹。