Research and Mentoring on Neurocognitive Disparities in Aging

项目摘要 拟议的K24以患者为导向的研究中期职业研究者奖旨在最好地使校长 研究员María Marquine博士将推进对衰老和阿尔茨海默氏症中神经认知差异的研究 西班牙裔/拉丁裔/as/x（以下简称西班牙裔）中的疾病和相关痴呆症（ADRDs）。马奎恩医生 研究计划围绕两个主要主题：1）识别风险和保护因素， 有和没有艾滋病毒的老年西班牙裔人的神经认知能力下降，2）开发工具， 准确识别美国西班牙语使用者的神经认知障碍。更 最近，她将后一个重点扩展到包括使用无处不在的移动的技术， ADRD风险识别。Marquine博士热衷于指导和支持以下方面的发展： 早期职业科学家，特别是那些来自代表性不足的少数民族（URM）背景的科学家。约 她的学员中有80%来自弱势群体，她的学员来自各种不同的背景， 职业生涯阶段，从高中到早期的职业生涯教师。她目前是两个国家情报局资助的联合研究员 研究教育计划，圣地亚哥阿尔茨海默病资源中心少数民族老龄化研究 （AD-RCMAR）和加州圣地亚哥大学（UCSD）通过老龄化研究推进多样性 （阿达尔）计划，以及关于老龄化和艾滋病毒的R25研究教育计划的副主任。她也是一个 加州大学圣地亚哥分校西班牙裔卓越中心的导师，加州大学圣地亚哥分校的几个NIH资助的T32培训项目， 以及圣地亚哥州立大学（SDSU）/加州大学圣地亚哥分校临床心理学联合博士项目。实现一个 职业中期研究者奖将允许Marquine博士保护时间继续推进她的研究 在神经认知差异和ADRD计划，深化她的承诺，指导初级临床科学家， 在这一领域开展研究，并获得指导和领导技能方面的正式培训。该奖项 还将为神经心理学规范标准的制定提供支持， 在老年西班牙语人群中，与ADRD相关的神经认知障碍，这是必要的一步， 在这个未被充分研究的群体中推进ADRD研究。在她的研究和指导活动中， 博士Marquine将利用UCSD三个主要研究中心的资源，即Stein 老龄化研究所，Shiley-Marcos阿尔茨海默病研究中心和艾滋病毒 神经行为研究计划。这些研究中心共同建立并维持了一个高效的 研究和培训基础设施，将作为Marquine博士自己研究的重要资源 计划和她的学员。

PROJECT SUMMARY The proposed K24 Midcareer Investigator Award in Patient-Oriented Research aims to best enable the Principal Investigator, Dr. María Marquine, to advance research on neurocognitive disparities in aging and Alzheimer’s Disease and Related Dementias (ADRDs) among Hispanics/Latinos/as/x (henceforth Hispanics). Dr. Marquine’s research program has centered around two major themes: 1) the identification of risk and protective factors for neurocognitive decline among older Hispanics with and without HIV, and 2) the development of tools for the accurate identification of neurocognitive impairment among Spanish-speakers in the United States. More recently, she has extended this latter focus to include the use of ubiquitous mobile technology for the identification of ADRD risk. Dr. Marquine is passionate about mentoring and supporting the advancement of early career scientists, particularly those from underrepresented minority (URM) backgrounds. Approximately 80% of her mentees have been from disadvantaged backgrounds, and her mentees have spanned various career stages, from high-school to early career faculty. She is currently a co-Investigator on two NIA-funded research education programs, the San Diego Alzheimer’s Disease-Resource Center for Minority Aging Research (AD-RCMAR) and the University of California San Diego (UCSD) Advancing Diversity through Aging Research (ADAR) program, and Deputy Director of an R25 Research Education Program on aging and HIV. She is also a mentor in the UCSD Hispanic Center of Excellence, several NIH-funded T32 training programs housed at UCSD, and the San Diego State University (SDSU)/UCSD Joint Doctoral Program in Clinical Psychology. Attaining a Midcareer Investigator Award would allow Dr. Marquine protected time to continue advancing her research program in neurocognitive disparities and ADRD, deepen her commitment to mentor junior clinical scientists in the conduct of research in this area, and obtain formal training in mentoring and leadership skills. The award would also provide support for the development of neuropsychological normative standards to detect neurocognitive impairment associated with ADRDs among older Spanish-speakers, which is a necessary step toward the advancement of ADRD research in this understudied group. In her research and mentoring activities, Dr. Marquine will leverage resources available within three major research centers at UCSD, namely, the Stein Institute for Research on Aging, the Shiley-Marcos Alzheimer’s Disease Research Center, and the HIV Neurobehavioral Research Program. Together, these research centers have built and maintain a highly effective research and training infrastructure that will serve as an important resource for Dr. Marquine’s own research program and that of her mentees.