Research and Mentoring on Neurocognitive Disparities in Aging

项目总结 拟议的K24以患者为中心的研究生涯中期调查员奖旨在最好地使校长 研究人员María Marquine博士推动对衰老和阿尔茨海默氏症神经认知差异的研究 拉美裔/拉丁裔/AS/x(以下简称拉美裔)中的疾病和相关痴呆(ADRD)。马奎因医生的 研究计划围绕两个主要主题：1)确定风险和保护因素 患有和不患有艾滋病毒的西班牙裔老年人的神经认知能力下降，以及2)工具的开发 准确识别在美国说西班牙语的人的神经认知障碍。更多 最近，她将后一种关注扩展到包括使用无处不在的移动技术来 识别ADRD风险。Marquine博士热衷于指导和支持 早期职业科学家，特别是那些来自代表不足的少数民族(URM)背景的科学家。大致 她的学员中有80%来自贫困家庭，而且学员的年龄跨度也不同 职业生涯阶段，从高中到职业生涯早期的教员。她目前是NIA资助的两个项目的联合调查员 研究教育项目，圣地亚哥阿尔茨海默病-少数民族老龄化研究资源中心 (ad-RCMAR)和加州大学圣地亚哥分校(UCSD)通过老龄化研究促进多样性 (ADAR)计划，R25老龄化和艾滋病毒研究教育计划副主任。她也是一个 加州大学圣迭戈分校拉美裔卓越中心的导师，加州大学圣迭戈分校由NIH资助的几个T32培训项目， 和圣地亚哥州立大学(SDSU)/加州大学圣地亚哥分校临床心理学联合博士项目。达到了一个 职业生涯中期研究人员奖将允许Marquine博士有时间继续推进她的研究 神经认知差异和ADRD计划，深化她对指导初级临床科学家的承诺 在这一领域进行研究，并获得关于指导和领导技能的正式培训。获奖名单 还将为制定神经心理学规范标准以检测 说西班牙语的老年人中与ADRDS相关的神经认知障碍，这是必要的一步 在这一未被充分研究的群体中推进ADRD研究。在她的研究和指导活动中， 马奎因博士将利用加州大学圣迭戈分校三个主要研究中心的现有资源，即斯坦因 老龄化研究所、Shiley-Marcos阿尔茨海默病研究中心和艾滋病毒 神经行为研究计划。这些研究中心共同建立并保持了高效的 研究和培训基础设施将成为马昆博士自己研究的重要资源 计划和她的导师的计划。

PROJECT SUMMARY The proposed K24 Midcareer Investigator Award in Patient-Oriented Research aims to best enable the Principal Investigator, Dr. María Marquine, to advance research on neurocognitive disparities in aging and Alzheimer’s Disease and Related Dementias (ADRDs) among Hispanics/Latinos/as/x (henceforth Hispanics). Dr. Marquine’s research program has centered around two major themes: 1) the identification of risk and protective factors for neurocognitive decline among older Hispanics with and without HIV, and 2) the development of tools for the accurate identification of neurocognitive impairment among Spanish-speakers in the United States. More recently, she has extended this latter focus to include the use of ubiquitous mobile technology for the identification of ADRD risk. Dr. Marquine is passionate about mentoring and supporting the advancement of early career scientists, particularly those from underrepresented minority (URM) backgrounds. Approximately 80% of her mentees have been from disadvantaged backgrounds, and her mentees have spanned various career stages, from high-school to early career faculty. She is currently a co-Investigator on two NIA-funded research education programs, the San Diego Alzheimer’s Disease-Resource Center for Minority Aging Research (AD-RCMAR) and the University of California San Diego (UCSD) Advancing Diversity through Aging Research (ADAR) program, and Deputy Director of an R25 Research Education Program on aging and HIV. She is also a mentor in the UCSD Hispanic Center of Excellence, several NIH-funded T32 training programs housed at UCSD, and the San Diego State University (SDSU)/UCSD Joint Doctoral Program in Clinical Psychology. Attaining a Midcareer Investigator Award would allow Dr. Marquine protected time to continue advancing her research program in neurocognitive disparities and ADRD, deepen her commitment to mentor junior clinical scientists in the conduct of research in this area, and obtain formal training in mentoring and leadership skills. The award would also provide support for the development of neuropsychological normative standards to detect neurocognitive impairment associated with ADRDs among older Spanish-speakers, which is a necessary step toward the advancement of ADRD research in this understudied group. In her research and mentoring activities, Dr. Marquine will leverage resources available within three major research centers at UCSD, namely, the Stein Institute for Research on Aging, the Shiley-Marcos Alzheimer’s Disease Research Center, and the HIV Neurobehavioral Research Program. Together, these research centers have built and maintain a highly effective research and training infrastructure that will serve as an important resource for Dr. Marquine’s own research program and that of her mentees.