Delaware Center for Musculoskeletal Research – Administrative Core

项目摘要/摘要 特拉华州肌肉骨骼研究中心(DCMR)将支持以下基础和临床前研究 肌肉骨骼健康和疾病的中心主题，从整个身体的水平到分子，以及 强调物理和生物线索影响组织结构和正常的机制 功能、功能障碍和潜在的治疗干预。强大的管理核心将最大限度地提高 通过成功领导中心的行政和财政运作以及通过 支持中心内部相互交织并利用现有资源的复杂科学行动 通过特拉华大学及其他地区的各个中心(目标1)。卓越与事业 项目负责人的发展对中心的成功至关重要，因为他们进行了有影响力的工作 中心内的肌肉骨骼研究和未来的独立调查人员。因此，行政部门 CORE还将为项目负责人实施全面的指导和职业发展计划， 补充正式的部门指导，使他们能够启动成功的研究计划和 取得独立调查员地位(目标2)。行政核心还将努力扩大 DCMR通过建立一个协作的跨学科社区，支持一个试点赠款计划， 招聘新教员和留住教员(目标3)。最后，核心将建立一个严格的评估计划，以 在项目评估中使用最佳实践并由专家领导，评估实现中心里程碑的进展情况 内部评估员(目标4)。除了内部和外部咨询委员会的投入外，评价数据将 用于持续改进中心并确保其实现其首要目标：加速 基础和临床前肌肉骨骼研究，并有助于全面的基础到临床 将大大减轻肌肉骨骼疾病负担的研究流水线。

PROJECT SUMMARY / ABSTRACT The Delaware Center for Musculoskeletal Research (DCMR) will support basic and preclinical research on the central theme of musculoskeletal health and disorders, from the level of the entire body to the molecule, with an emphasis on the mechanisms by which physical and biological cues influence tissue structure and normal function, dysfunction, and potential therapeutic interventions. A strong Administrative Core will maximize the impact of the DCMR by successfully leading the administrative and fiscal operation of the Center and by supporting complex scientific operations that are interwoven within the Center and draw on resources available through various centers across the University of Delaware and beyond (Aim 1). Excellence and career development of the Project Leaders is critical to the success of the Center, as they conduct impactful musculoskeletal research within the Center and as future independent investigators. Thus, the Administrative Core will also implement a comprehensive mentoring and career development plan for Project Leaders that complements formal departmental mentoring and will enable them to launch successful research programs and attain independent investigator status (Aim 2). The Administrative Core will also work to expand the impact of the DCMR through establishing a collaborative interdisciplinary community, supporting a Pilot grant program, hiring new faculty, and retaining faculty (Aim 3). Finally, the Core will establish a rigorous evaluation program to assess progress toward Center milestones, using best practices in program evaluation and led by an expert internal evaluator (Aim 4). Added to the input of internal and external advisory committees, evaluation data will be used to continuously improve the Center and ensure that it is achieving its overarching goal: to accelerate fundamental and preclinical musculoskeletal research and contribute to a comprehensive basic-to-clinical research pipeline that will substantially reduce the burden of musculoskeletal disorders.