Delaware Center for Musculoskeletal Research

特拉华肌肉骨骼研究中心

基本信息

  • 批准号:
    10091019
  • 负责人:
  • 金额:
    $ 235.01万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-02-15 至 2026-01-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT The musculoskeletal system has both mechanical and biological functions—it generates, transmits, and supports forces, and it regulates organ-level homeostasis and whole-body metabolism. The mechanics and biology of the musculoskeletal system are inextricably intertwined and long-ranging, where mechanical cues, molecular signals, and cell interactions affect each other across multiple scales, from the body, to organ, tissue, cell, and molecule levels. Progress in musculoskeletal research depends on addressing the mechanics and biology of adjacent organs, and evaluating the effects of injury as well as aging. Identifying the mechanisms underlying musculoskeletal health and musculoskeletal disorders (e.g., osteoarthritis, osteoporosis, muscle wasting, post-traumatic repair, degeneration) therefore requires a research paradigm that addresses the synergies within the musculoskeletal system and combines both mechanical and biological approaches across multiple scales. The Delaware Center for Musculoskeletal Research (DCMR) will support basic and preclinical research on the central theme of musculoskeletal health—from the level of the entire body to the actions of key cells and molecules—with emphasis on understanding the mechanisms by which physical and biological cues influence tissue structure and normal function and dysfunction, and identifying potential therapeutic interventions. The proposed DCMR will: Aim 1: Accelerate fundamental musculoskeletal research by supporting synergistic and multidisciplinary Research Projects. Aim 2: Galvanize capabilities for musculoskeletal research by establishing a Multiscale Assessments Research Core. Aim 3: Amplify the impact of musculoskeletal research through faculty mentoring, expansion, and retention. Completion of this 5-year Phase I COBRE will build cross-cutting and synergistic research collaborations across multi-scale and multidisciplinary Research Projects and establish a state-of-the-art Research Core. The DCMR, which will focus on fundamental discovery and preclinical research, will complement the outstanding translational and clinical musculoskeletal research programs at Delaware, creating a comprehensive basic-to- clinical research pipeline at UD. Through fostering cross-cutting and convergent research partnerships, the DCMR aims to substantially reduce the burden of musculoskeletal disorders and improve musculoskeletal health.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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DAWN M ELLIOTT其他文献

DAWN M ELLIOTT的其他文献

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{{ truncateString('DAWN M ELLIOTT', 18)}}的其他基金

Multiscale tendon damage and aberrant cellular responses in an in vivo model of tendinosis
肌腱变性体内模型中的多尺度肌腱损伤和异常细胞反应
  • 批准号:
    10687977
  • 财政年份:
    2022
  • 资助金额:
    $ 235.01万
  • 项目类别:
Multiscale tendon damage and aberrant cellular responses in an in vivo model of tendinosis
肌腱变性体内模型中的多尺度肌腱损伤和异常细胞反应
  • 批准号:
    10343017
  • 财政年份:
    2022
  • 资助金额:
    $ 235.01万
  • 项目类别:
Delaware Center for Musculoskeletal Research, Administrative Supplement for Equipment
特拉华州肌肉骨骼研究中心,设备行政补充资料
  • 批准号:
    10591284
  • 财政年份:
    2021
  • 资助金额:
    $ 235.01万
  • 项目类别:
Delaware Center for Musculoskeletal Research - Wang
特拉华州肌肉骨骼研究中心 - 王
  • 批准号:
    10854179
  • 财政年份:
    2021
  • 资助金额:
    $ 235.01万
  • 项目类别:
Delaware Center for Musculoskeletal Research – Administrative Core
特拉华州肌肉骨骼研究中心 — 行政核心
  • 批准号:
    10091020
  • 财政年份:
    2021
  • 资助金额:
    $ 235.01万
  • 项目类别:
Delaware Center for Musculoskeletal Research
特拉华肌肉骨骼研究中心
  • 批准号:
    10352300
  • 财政年份:
    2021
  • 资助金额:
    $ 235.01万
  • 项目类别:
Delaware Center for Musculoskeletal Research – Administrative Core
特拉华州肌肉骨骼研究中心 — 行政核心
  • 批准号:
    10352302
  • 财政年份:
    2021
  • 资助金额:
    $ 235.01万
  • 项目类别:
Delaware Center for Musculoskeletal Research – Administrative Core
特拉华州肌肉骨骼研究中心 – 行政核心
  • 批准号:
    10885870
  • 财政年份:
    2021
  • 资助金额:
    $ 235.01万
  • 项目类别:
Delaware Center for Musculoskeletal Research – Administrative Core
特拉华州肌肉骨骼研究中心 – 行政核心
  • 批准号:
    10782401
  • 财政年份:
    2021
  • 资助金额:
    $ 235.01万
  • 项目类别:
Simulating Workforce Design Teams in Biomedical Engineering Education
模拟生物医学工程教育中的劳动力设计团队
  • 批准号:
    10204530
  • 财政年份:
    2021
  • 资助金额:
    $ 235.01万
  • 项目类别:

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Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
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Parkinson's disease and aging affect neural activation during continuous gait alterations to the split-belt treadmill: An [18F] FDG PET Study.
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阐明衰老过程中肠上皮细胞影响糖耐量受损的机制
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    19K09017
  • 财政年份:
    2019
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    $ 235.01万
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Does aging of osteocytes adversely affect bone metabolism?
骨细胞老化会对骨代谢产生不利影响吗?
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    18K09531
  • 财政年份:
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Links between affect, executive function, and prefrontal structure in aging: A longitudinal analysis
衰老过程中情感、执行功能和前额叶结构之间的联系:纵向分析
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  • 财政年份:
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影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
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    9320090
  • 财政年份:
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影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
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Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
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