Delaware Center for Musculoskeletal Research
特拉华肌肉骨骼研究中心
基本信息
- 批准号:10091019
- 负责人:
- 金额:$ 235.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-02-15 至 2026-01-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAgingAreaBasic ScienceBiologicalBiological ProcessBiologyCell CommunicationCellsCenters of Research ExcellenceClinicalClinical ResearchCollaborationsCommunitiesComplementCuesDegenerative polyarthritisDelawareEquipmentExtramural ActivitiesFacultyFosteringFunctional disorderFundingGoalsGrantHealthHealth StatusHomeostasisInflammationInjuryInterdisciplinary StudyLeadershipMechanicsMentorsMetabolismMolecularMuscular AtrophyMusculoskeletalMusculoskeletal DiseasesMusculoskeletal SystemOrganOsteoporosisPhaseResearchResearch PersonnelResearch Project GrantsResearch SupportRoleSignal TransductionStructureTechnical ExpertiseTestingTherapeutic InterventionTissuesTrainingUniversitiescareer developmentfaculty mentorfunctional restorationimprovedmechanical forcemultidisciplinarypre-clinical researchprogramsrecruitrepairedsuccesssynergism
项目摘要
PROJECT SUMMARY/ABSTRACT
The musculoskeletal system has both mechanical and biological functions—it generates, transmits, and
supports forces, and it regulates organ-level homeostasis and whole-body metabolism. The mechanics and
biology of the musculoskeletal system are inextricably intertwined and long-ranging, where mechanical cues,
molecular signals, and cell interactions affect each other across multiple scales, from the body, to organ, tissue,
cell, and molecule levels. Progress in musculoskeletal research depends on addressing the mechanics and
biology of adjacent organs, and evaluating the effects of injury as well as aging. Identifying the mechanisms
underlying musculoskeletal health and musculoskeletal disorders (e.g., osteoarthritis, osteoporosis, muscle
wasting, post-traumatic repair, degeneration) therefore requires a research paradigm that addresses the
synergies within the musculoskeletal system and combines both mechanical and biological approaches across
multiple scales.
The Delaware Center for Musculoskeletal Research (DCMR) will support basic and preclinical
research on the central theme of musculoskeletal health—from the level of the entire body to the actions
of key cells and molecules—with emphasis on understanding the mechanisms by which physical and
biological cues influence tissue structure and normal function and dysfunction, and identifying potential
therapeutic interventions. The proposed DCMR will:
Aim 1: Accelerate fundamental musculoskeletal research by supporting synergistic and multidisciplinary
Research Projects.
Aim 2: Galvanize capabilities for musculoskeletal research by establishing a Multiscale Assessments
Research Core.
Aim 3: Amplify the impact of musculoskeletal research through faculty mentoring, expansion, and retention.
Completion of this 5-year Phase I COBRE will build cross-cutting and synergistic research collaborations
across multi-scale and multidisciplinary Research Projects and establish a state-of-the-art Research Core. The
DCMR, which will focus on fundamental discovery and preclinical research, will complement the outstanding
translational and clinical musculoskeletal research programs at Delaware, creating a comprehensive basic-to-
clinical research pipeline at UD. Through fostering cross-cutting and convergent research partnerships, the
DCMR aims to substantially reduce the burden of musculoskeletal disorders and improve musculoskeletal
health.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DAWN M ELLIOTT其他文献
DAWN M ELLIOTT的其他文献
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{{ truncateString('DAWN M ELLIOTT', 18)}}的其他基金
Multiscale tendon damage and aberrant cellular responses in an in vivo model of tendinosis
肌腱变性体内模型中的多尺度肌腱损伤和异常细胞反应
- 批准号:
10687977 - 财政年份:2022
- 资助金额:
$ 235.01万 - 项目类别:
Multiscale tendon damage and aberrant cellular responses in an in vivo model of tendinosis
肌腱变性体内模型中的多尺度肌腱损伤和异常细胞反应
- 批准号:
10343017 - 财政年份:2022
- 资助金额:
$ 235.01万 - 项目类别:
Delaware Center for Musculoskeletal Research, Administrative Supplement for Equipment
特拉华州肌肉骨骼研究中心,设备行政补充资料
- 批准号:
10591284 - 财政年份:2021
- 资助金额:
$ 235.01万 - 项目类别:
Delaware Center for Musculoskeletal Research - Wang
特拉华州肌肉骨骼研究中心 - 王
- 批准号:
10854179 - 财政年份:2021
- 资助金额:
$ 235.01万 - 项目类别:
Delaware Center for Musculoskeletal Research – Administrative Core
特拉华州肌肉骨骼研究中心 — 行政核心
- 批准号:
10091020 - 财政年份:2021
- 资助金额:
$ 235.01万 - 项目类别:
Delaware Center for Musculoskeletal Research – Administrative Core
特拉华州肌肉骨骼研究中心 — 行政核心
- 批准号:
10352302 - 财政年份:2021
- 资助金额:
$ 235.01万 - 项目类别:
Delaware Center for Musculoskeletal Research – Administrative Core
特拉华州肌肉骨骼研究中心 – 行政核心
- 批准号:
10885870 - 财政年份:2021
- 资助金额:
$ 235.01万 - 项目类别:
Delaware Center for Musculoskeletal Research – Administrative Core
特拉华州肌肉骨骼研究中心 – 行政核心
- 批准号:
10782401 - 财政年份:2021
- 资助金额:
$ 235.01万 - 项目类别:
Simulating Workforce Design Teams in Biomedical Engineering Education
模拟生物医学工程教育中的劳动力设计团队
- 批准号:
10204530 - 财政年份:2021
- 资助金额:
$ 235.01万 - 项目类别:
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