Delaware Center for Musculoskeletal Research – Administrative Core

特拉华州肌肉骨骼研究中心 – 行政核心

• 批准号: 10782401
• 负责人: DAWN M ELLIOTT
• 金额: $ 30.68万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10782401
• 关键词: Acceleration; Advisory Committees; Annual Reports; Attention; Basic Science; Biological; Breast Cancer Treatment; Clinical Research; Collaborations; Communication; Communities; Complement; Complex; Cues; Data; Delaware; Development; Development Plans; Disease; Ensure; Evaluation; Extramural Activities; Faculty; Functional disorder; Funding; Future; Goals; Grant; Growth; Health; Infrastructure; Leadership; Mentors; Modality; Musculoskeletal; Musculoskeletal Diseases; Office of Administrative Management; Osteolysis; Periodicals; Program Development; Program Evaluation; Reporting; Research; Research Personnel; Research Project Grants; Resources; Structure; Therapeutic Intervention; Tissues; United States National Institutes of Health; Universities; Work; carcinogenesis; career development; formative assessment; improved; meetings; novel; operation; pre-clinical; pre-clinical research; programs; recruit; success; tool

PROJECT SUMMARY / ABSTRACT The Delaware Center for Musculoskeletal Research (DCMR) will support basic and preclinical research on the central theme of musculoskeletal health and disorders, from the level of the entire body to the molecule, with an emphasis on the mechanisms by which physical and biological cues influence tissue structure and normal function, dysfunction, and potential therapeutic interventions. A strong Administrative Core will maximize the impact of the DCMR by successfully leading the administrative and fiscal operation of the Center and by supporting complex scientific operations that are interwoven within the Center and draw on resources available through various centers across the University of Delaware and beyond (Aim 1). Excellence and career development of the Project Leaders is critical to the success of the Center, as they conduct impactful musculoskeletal research within the Center and as future independent investigators. Thus, the Administrative Core will also implement a comprehensive mentoring and career development plan for Project Leaders that complements formal departmental mentoring and will enable them to launch successful research programs and attain independent investigator status (Aim 2). The Administrative Core will also work to expand the impact of the DCMR through establishing a collaborative interdisciplinary community, supporting a Pilot grant program, hiring new faculty, and retaining faculty (Aim 3). Finally, the Core will establish a rigorous evaluation program to assess progress toward Center milestones, using best practices in program evaluation and led by an expert internal evaluator (Aim 4). Added to the input of internal and external advisory committees, evaluation data will be used to continuously improve the Center and ensure that it is achieving its overarching goal: to accelerate fundamental and preclinical musculoskeletal research and contribute to a comprehensive basic-to-clinical research pipeline that will substantially reduce the burden of musculoskeletal disorders.

项目总结/摘要 特拉华州肌肉骨骼研究中心（DCMR）将支持以下基础和临床前研究： 肌肉骨骼健康和疾病的中心主题，从整个身体的水平到分子， 强调物理和生物线索影响组织结构和正常组织的机制， 功能、功能障碍和潜在的治疗干预。一个强有力的行政核心将最大限度地 通过成功领导中心的行政和财政运作， 支持复杂的科学运作，这些运作在中心内部交织在一起，并利用现有资源 通过特拉华州及其他大学的各个中心（目标1）。卓越与职业 项目负责人的发展对于中心的成功至关重要，因为他们的行为具有影响力 在中心内的肌肉骨骼研究，并作为未来的独立调查员。因此，行政 Core还将为项目领导者实施全面的指导和职业发展计划， 补充正式的部门指导，使他们能够推出成功的研究计划， 获得独立研究者地位（目标2）。行政核心还将努力扩大 DCMR通过建立一个合作的跨学科社区，支持试点赠款计划， 招聘新教师，留住教师（目标3）。最后，核心将建立严格的评估计划， 在专家的领导下，使用项目评估中的最佳实践，评估中心里程碑的进展情况 内部评价员（目标4）。除了内部和外部咨询委员会的投入外，评价数据将 用于持续改进中心，并确保实现其总体目标： 基础和临床前肌肉骨骼研究，并有助于全面的基础到临床 这将大大减轻肌肉骨骼疾病的负担。