Core A: Administrative Core

核心A：行政核心

• 批准号: 10351936
• 负责人: Bevin P. Engelward
• 金额: $ 19.45万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10351936
• 关键词: Achievement; Adoption; Advocacy; Carcinogens; Chemicals; Collaborations; Communication; Communities; Computing Methodologies; Data; Data Analyses; Dependence; Devices; Dimethylnitrosamine; Discipline; Disease; Educational process of instructing; Educational workshop; Engineering; Ensure; Environmental Health; Environmental Protection; Exposure to; Family; Felis catus; Filtration; Fostering; Future; Goals; Government Agencies; Hazardous Chemicals; Hazardous Substances; Health; Human; Infrastructure; Intervention; Investigator-Initiated Research; Knowledge; Lead; Leadership; Massachusetts; Mentors; Methods; Mission; Municipalities; Mutagens; N-nitrosodimethylamine; National Institute of Environmental Health Sciences; National Toxicology Program; Nitrosamines; Persons; Play; Public Health; Research; Risk; Role; Safety; Science; Source; Suggestion; Sum; Superfund; System; Technology; Technology Transfer; Training; Training Support; Translating; Translational Research; Translations; Tribes; Underrepresented Students; United States Environmental Protection Agency; United States Food and Drug Administration; Water; Work; career; community engagement; data management; data sharing; data streams; drinking water; experience; high throughput screening; improved; innovation; meetings; member; next generation; novel; posters; programs; remediation; restoration; sensor; success; superfund chemical; superfund site; tribal organization; wasting; water treatment

PROJECT SUMMARY/ABSTRACT – ADMINISTRATIVE CORE N-nitrosamines are a family of chemicals that include some of the most potent mutagens known. N-nitrosamines are a major concern for people who live near the Olin Chemical Superfund Site, which is contaminated with millions of gallons of waste containing high levels of N-nitrosodimethylamine (NDMA), a probable human carcinogen. NDMA is also a concern of the Passamaquoddy Tribe, because the water treatment methods used for their drinking water are known to lead to formation of NDMA. The mission of the Administrative Core is to enable a Systems Approach wherein impact on public health is made possible via a network of interactions and interdependencies among Projects, Cores, and stakeholders. The resulting ‘MIT SRP Interactome’ results from research meetings, enrichment activities, workshops, retreats, poster sessions, trainee collaboration meetings, and meetings with stakeholders. Team building will be further strengthened via adoption and enhancement of team science values. Translation will be fostered via support of Project and Core leaders in developing and executing their Investigator Initiated Research Translation plans and by continual input and suggestions from the Administrative Core leadership, and in particular the Research Translation Coordinator. In addition to its Systems Approach, other innovative goals include facilitation of bidirectional communication with the National Toxicology Program to enable the MIT team to cater technologies to meet the needs for high-throughput screens for chemical safety and working with the Community Engagement Core (CEC) to deploy N-nitrosamine sensors and remediation devices that destroy N-nitrosamines. Specific Aim 1 is to lead and coordinate in order to achieve a robust programmatic ‘MIT SRP Interactome’ that will give rise to results and deliverables that contribute to the protection of human health from hazardous substances. Specific Aim 2 is to partner and promote by translating knowledge and technologies to local, state, national, and tribal organizations. Specific Aim 3 is to achieve a broader impact via dissemination of knowledge and by building a better future for the next generation of leaders in environmental health sciences. Communication and data sharing will be further strengthened by the Data Management and Analysis Core (DMAC), which will deliver computational methods for integrating data streams from across disciplines in order to contribute to a better understanding of risk, improved ability to predict disease, and new opportunities for interventions. The Administrative Core will also work closely with the Research Experience and Training Coordination Core (RETCC) to coordinate training and support for trainees. Taken together, the Administrative Core is the cog that drives the program forward by creating tight collaborations and interdependencies within the MIT SRP and with its local, state and national stakeholders, that together enable MIT SRP solutions that give rise to improved public health.

项目概要/摘要-行政核心 N-亚硝胺是一个化学家族，其中包括一些已知的最有效的诱变剂。亚硝胺 是奥林化学超级基金场地附近居民的主要担忧， 数百万加仑的废物含有高水平的N-亚硝基二甲胺（NDMA），这可能是人类 致癌物质NDMA也是Passamaquoddy部落关注的问题，因为使用的水处理方法 他们的饮用水会导致NDMA的形成。行政核心的使命是 采用系统方法，通过互动网络对公共卫生产生影响， 项目、核心和利益相关者之间的相互依赖性。由此产生的“MIT SRP Interactome”结果来自 研究会议，丰富活动，讲习班，务虚会，海报会议，学员合作会议， 与利益攸关方举行会议。通过采用和加强 团队科学价值观翻译将通过项目和核心领导人在开发和 执行其研究者发起的研究翻译计划，并通过来自 行政核心领导，特别是研究翻译协调员。除了其 系统方法，其他创新目标包括促进与国家 毒理学计划，使麻省理工学院的团队，以迎合技术，以满足高通量筛选的需求 化学品安全，并与社区参与核心（CEC）合作部署N-亚硝胺传感器 和破坏N-亚硝胺的补救装置。具体目标1是领导和协调，以便 实现一个强大的程序化的“麻省理工学院SRP互动组”，将产生的结果和交付成果， 有助于保护人类健康免受有害物质的危害。目标二：成为合作伙伴 并通过将知识和技术转化为地方，州，国家和部落来促进 组织的具体目标3是通过传播知识和 为环境健康科学的下一代领导者创造更美好的未来。 数据管理和分析核心将进一步加强通信和数据共享 （DMAC），它将提供用于整合跨学科数据流的计算方法， 有助于更好地了解风险，提高预测疾病的能力，并为 干预措施。行政核心还将与研究经验和培训中心密切合作。 协调中心（RETCC）负责协调培训和对受训人员的支助。总的来说，行政 核心是齿轮，通过在内部创建紧密的协作和相互依赖关系来推动程序向前发展。 麻省理工学院SRP及其地方，州和国家利益相关者，共同使麻省理工学院SRP解决方案， 提高公共卫生水平。