Core A: Administrative Core

核心A：行政核心

• 批准号: 10688002
• 负责人: Bevin P. Engelward
• 金额: $ 19.49万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10688002
• 关键词: Acceleration; Achievement; Adoption; Advocacy; Carcinogens; Chemicals; Collaborations; Communication; Communities; Computing Methodologies; Data; Data Analyses; Devices; Dimethylnitrosamine; Discipline; Disease; Educational process of instructing; Educational workshop; Engineering; Ensure; Environment; Environmental Health; Environmental Protection; Exposure to; Family; Filtration; Fostering; Future; Goals; Government Agencies; Hazardous Chemicals; Hazardous Substances; Health; Human; Infrastructure; Intervention; Knowledge; Lead; Leadership; Massachusetts; Mentors; Methods; Mission; Municipalities; Mutagens; N-nitrosodimethylamine; National Institute of Environmental Health Sciences; National Toxicology Program; Nitrosamines; Persons; Play; Probability; Public Health; Research; Risk; Role; Safety; Science; Source; Suggestion; Sum; Superfund; System; Systems Integration; Technology; Technology Transfer; Training; Translating; Translational Research; Translations; Tribes; Underrepresented Students; United States Environmental Protection Agency; United States Food and Drug Administration; Water; Work; career; chemical safety; community engagement; data integration; data management; data sharing; data streams; drinking water; experience; high throughput screening; improved; innovation; investigator-initiated translational research; meetings; member; next generation; novel; posters; programs; remediation; restoration; sensor; success; superfund chemical; superfund site; translational potential; tribal organization; wasting; water treatment

PROJECT SUMMARY/ABSTRACT – ADMINISTRATIVE CORE N-nitrosamines are a family of chemicals that include some of the most potent mutagens known. N-nitrosamines are a major concern for people who live near the Olin Chemical Superfund Site, which is contaminated with millions of gallons of waste containing high levels of N-nitrosodimethylamine (NDMA), a probable human carcinogen. NDMA is also a concern of the Passamaquoddy Tribe, because the water treatment methods used for their drinking water are known to lead to formation of NDMA. The mission of the Administrative Core is to enable a Systems Approach wherein impact on public health is made possible via a network of interactions and interdependencies among Projects, Cores, and stakeholders. The resulting ‘MIT SRP Interactome’ results from research meetings, enrichment activities, workshops, retreats, poster sessions, trainee collaboration meetings, and meetings with stakeholders. Team building will be further strengthened via adoption and enhancement of team science values. Translation will be fostered via support of Project and Core leaders in developing and executing their Investigator Initiated Research Translation plans and by continual input and suggestions from the Administrative Core leadership, and in particular the Research Translation Coordinator. In addition to its Systems Approach, other innovative goals include facilitation of bidirectional communication with the National Toxicology Program to enable the MIT team to cater technologies to meet the needs for high-throughput screens for chemical safety and working with the Community Engagement Core (CEC) to deploy N-nitrosamine sensors and remediation devices that destroy N-nitrosamines. Specific Aim 1 is to lead and coordinate in order to achieve a robust programmatic ‘MIT SRP Interactome’ that will give rise to results and deliverables that contribute to the protection of human health from hazardous substances. Specific Aim 2 is to partner and promote by translating knowledge and technologies to local, state, national, and tribal organizations. Specific Aim 3 is to achieve a broader impact via dissemination of knowledge and by building a better future for the next generation of leaders in environmental health sciences. Communication and data sharing will be further strengthened by the Data Management and Analysis Core (DMAC), which will deliver computational methods for integrating data streams from across disciplines in order to contribute to a better understanding of risk, improved ability to predict disease, and new opportunities for interventions. The Administrative Core will also work closely with the Research Experience and Training Coordination Core (RETCC) to coordinate training and support for trainees. Taken together, the Administrative Core is the cog that drives the program forward by creating tight collaborations and interdependencies within the MIT SRP and with its local, state and national stakeholders, that together enable MIT SRP solutions that give rise to improved public health.

项目摘要/摘要--行政核心 N-亚硝胺是一类化学物质，其中包括一些已知的最强的诱变剂。N-亚硝胺 是居住在奥林化学超级基金网站附近的人们的主要担忧，该网站受到 数百万加仑含有高浓度N-亚硝基二甲胺(NDMA)的废物，可能是人类 致癌物质。NDMA也是帕萨马科迪部落的一个关切，因为使用的水处理方法 因为他们的饮用水被认为会导致NDMA的形成。行政核心的使命是 采用一种系统方法，通过互动网络和 项目、核心和利益相关者之间的相互依赖关系。由此产生的‘MIT SRP Interactome’结果来自 研究会议、充实活动、研讨会、务虚会、海报会议、实习生协作会、 以及与利益相关者的会议。团队建设将通过采用和加强 团队科学价值观。将通过支持项目和核心领导在开发和 执行他们的研究人员发起的研究翻译计划，并通过不断输入和建议 行政核心领导，特别是研究翻译协调员。除了它的 系统方法，其他创新目标包括促进与国家 毒理学计划，使麻省理工学院团队能够满足高通量筛查需求的技术 化学安全和与社区参与核心(CEC)合作部署N-亚硝胺传感器 以及破坏N-亚硝胺的补救装置。具体目标1是领导和协调，以便 实现一个强有力的程序性‘麻省理工学院SRP互动组’，这将产生以下结果和交付成果 有助于保护人类健康免受危险物质的伤害。具体目标2是合作伙伴 并通过将知识和技术转化为地方、州、国家和部落来促进 组织。具体目标3是通过传播知识和通过 为环境健康科学的下一代领导者创造更美好的未来。 数据管理和分析核心将进一步加强通信和数据共享 (DMAC)，它将提供计算方法，以按顺序整合来自不同学科的数据流 有助于更好地了解风险，提高预测疾病的能力，并为 干预措施。行政核心还将与研究经验和培训密切合作 协调核心(RETCC)，以协调对受训者的培训和支持。总而言之，行政部门 核心是推动程序向前发展的齿轮，它通过在 麻省理工学院SRP及其地方、州和国家利益相关者，共同支持麻省理工学院SRP解决方案，提供 提高公共卫生水平。