RADx-UP CDCC SAY YES COVID Test Study

RADx-UP CDCC 同意 COVID 测试研究

• 批准号: 10366485
• 负责人: Michael Cohen-Wolkowiez
• 金额: $ 765.38万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-27 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10366485
• 关键词: 2019-nCoV; Address; Admission activity; Affect; Attitude; Behavior; Behavioral; Bioinformatics; Biometry; COVID test; COVID-19 pandemic; Centers for Disease Control and Prevention (U.S.); Cessation of life; Clinical Research; Clinical Trials; Communities; Consent; Contact Tracing; County; Data; Data Collection; Disease; Epidemiology; Evaluation; Future; Goals; Health; Health Knowledge, Attitudes, Practice; Health behavior; High Prevalence; Home; Hospitalization; Hospitals; Human; Individual; Infection; Infrastructure; Intervention; Knowledge; Lead; Leadership; Measures; Morbidity - disease rate; North Carolina; Outcome; Participant; Population; Population Programs; Prevention; Public Health; Quarantine; RADx; Research; Research Institute; SARS-CoV-2 infection; SARS-CoV-2 transmission; Science; Site; Social Interaction; Target Populations; Testing; Time; Underserved Population; United States National Institutes of Health; Universities; Vaccines; Viral; Virus; Vision; cohort; community engagement; coronavirus disease; cost; experience; health care service utilization; health equity; home test; indexing; marginalized population; novel; novel strategies; operation; pandemic disease; primary outcome; programs; public health intervention; rapid test; research study; screening; secondary outcome; skills; smartphone Application; transmission process; uptake; wastewater surveillance

Over 4 million people have been infected with the SARS-CoV-2 virus and more than 460,000 have died. Novel mitigation strategies and community level public health interventions are critical to stop the spread of this virus. The goal of frequent home testing is to identify SARS-CoV-2 index cases early, trigger isolation and quarantining precautions, and ultimately decrease community transmission. We will evaluate a public health intervention combining frequent at-home testing with broad community engagement strategies, to reduce SARS-CoV-2 virus community transmission and conduct a study in a cohort of the population to understand the human behavior factors affecting viral testing. This approach will allow us to answer questions regarding community transmission for the SARS-CoV-2 pandemic as well as additional questions relevant for implementation of public health interventions in future pandemics. We will partner with the CDC to evaluate community dissemination of 2 million rapid tests in a public health intervention of rapid, twice weekly at home testing in up to 3 communities 1) with high prevalence of disease 2) that have reliable publicly available outcome data and 3) that overlap with current RADx-UP sites to leverage the robust infrastructure of the CDCC and support community engagement through the testing projects. To evaluate whether frequent rapid at-home testing strategy decreases community transmission of and morbidity from SARS-CoV-2 over a 5-week period, our primary outcomes include measures of community transmission (hospital capacity/health care utilization, composite measure of community transmission, wastewater surveillance), and morbidity (hospitalizations, covid-like illness). Our secondary outcomes include (community mobility, PCR turn-around time, ICU admissions, contact tracing episodes, and percent test positivity). In addition, we will conduct a substudy to assess behavioral determinants of testing (social interaction, health behaviors, healthcare utilization, prevention knowledge and vaccine attitudes) using a smart phone application with consenting participants in the public health intervention.

超过400万人感染了SARS-CoV-2病毒，超过46万人死亡。小说 缓解战略和社区一级的公共卫生干预措施对于阻止这一病毒的传播至关重要。 频繁进行家庭检测的目的是及早发现SARS-CoV-2指数病例，触发隔离， 加强预防措施，最终减少社区传播。我们将评估一个公共卫生 将频繁的家庭检测与广泛的社区参与战略相结合， SARS-CoV-2病毒的社区传播并在人群中进行队列研究以了解 影响病毒检测的人类行为因素。这种方法将使我们能够回答有关 SARS-CoV-2大流行的社区传播以及与以下方面相关的其他问题 在未来的大流行病中实施公共卫生干预措施。我们将与疾控中心合作， 在社区分发200万个快速检测，每周两次在家中进行快速公共卫生干预 在最多3个社区进行检测，1）疾病流行率高，2）有可靠的公共可用的 结果数据; 3）与当前RADx-UP站点重叠，以利用CDCC强大的基础设施 并通过测试项目支持社区参与。评估是否在家中频繁快速 检测策略在5周内减少了SARS-CoV-2的社区传播和发病率， 我们的主要结果包括社区传播的测量（医院容量/卫生保健利用， 社区传播、废水监测的综合指标）和发病率（住院， 类Covid疾病）。我们的次要结局包括（社区流动性、PCR周转时间、ICU 入院、接触者追踪事件和测试阳性百分比）。此外，我们还将进行一项子研究， 评估测试的行为决定因素（社会互动，健康行为，医疗保健利用， 预防知识和疫苗态度）使用智能手机应用程序与同意的参与者， 公共卫生干预。