RADx-UP CDCC

RADx-UPCDCC

• 批准号: 10844144
• 负责人: Michael Cohen-Wolkowiez
• 金额: $ 1272.91万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-27 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10844144
• 关键词: 2019-nCoV; Address; Adult; Behavioral; Biometry; Biostatistics Core; COVID-19; COVID-19 disparity; COVID-19 morbidity; COVID-19 pandemic; COVID-19 pandemic effects; COVID-19 testing; Cessation of life; Child; Clinical Research; Collaborations; Communities; Community of Practice; Data; Data Collection; Data Science; Data Sources; Diagnostic Procedure; Effectiveness; Ensure; Equity; Ethics; Funding; Future; Goals; Health; Health system; Inequality; Informatics; Infrastructure; Leadership; Office of Administrative Management; Outcome; Participant; Pattern; Persons; Pilot Projects; Population Programs; Protocols documentation; Public Health; RADx Underserved Populations; Research; Research Institute; Research Personnel; Research Project Grants; Research Support; SARS-CoV-2 infection; Science; Scientific Advances and Accomplishments; Services; Social Justice; Testing; Underserved Population; United States National Institutes of Health; Universities; Virus; Vision; Vulnerable Populations; Work; community center; community engaged research; community engagement; community involvement; data management; data repository; data standards; design; disparity reduction; diverse data; experience; flexibility; health disparity; health equity; improved; infrastructure development; interest; lens; marginalized population; mortality; multidisciplinary; pandemic disease; prevent; programs; recruit; social; statistics

ABSTRACT There is an urgent need to reduce disparities in COVID-19 associated morbidity and mortality outcomes in historically marginalized and vulnerable populations disproportionately affected by the COVID-19 pandemic. To address this need the Rapid Acceleration of Diagnostics for Underserved Populations (RADx-UP) program will support Community-Engaged Testing Research Projects and Social, Ethical and Behavioral Implications (SEBI) Research Projects to understand SARS-CoV-2 infection patterns and increase access and effectiveness of diagnostic methods in underserved and/or vulnerable populations. The Duke Clinical Research Institute (DCRI), the UNC Center for Health Equity Research (CHER), and Community-Campus Partnerships for Health (CCPH) propose to serve as the Coordination and Data Collection Center (CDCC) to provide management, direction, and overall coordination of the RADx-UP consortium. Together, our multidisciplinary experience in project coordination; COVID-19 thought leadership; regulatory science; community engagement; health equity research; social justice; adult and child research; statistics; data science; and clinical research informatics will advance the objectives of the projects in the RADx-UP Program. Our overarching goal is to implement a community-centered approach and establish an effective, flexible, participatory, and sustainable CDCC that will serve as the infrastructure to maximize the community impact of projects in the RADx-UP Program. To achieve this vision, we will establish a program framework comprised of four cores. Our Administration and Coordination Core, in collaboration with NIH scientific staff, will facilitate the work of the RADx-UP Program in overarching administrative management. The COVID-19 Testing Core will advise and guide COVID-19 testing protocols; curate emergent testing data; and administer the Rapid Pilot Studies Program. The Community and Health System Engagement Core will support a community of practice across the RADx-UP Program; provide support in exchanging best practices across communities on recruitment, engagement, and retention of study participants; and coordinate the dissemination of study findings from RADx-UP projects. The Data Science and Biostatistics Core will manage data collection, integration, and sharing for the RADx-UP Program including merging and harmonization of multiple and diverse data sources and provide data standards, data collection design, and biostatistics consulting services. The RADx-UP CDCC goals will be met using established infrastructure and subject matter experts and will be customized to meet the variable needs of the RADx-UP community. Using the highest research standards, our team will accomplish the goals set out by the NIH in managing this critically important collaborative effort.

抽象的 迫切需要减少199年相关的发病率和死亡率的差异 历史上被边缘化和脆弱的人群不成比例地受到19日大流行的影响。到 解决此需要快速加速服务不足的人群（RADX-UP）计划 支持社区参与的测试研究项目以及社会，道德和行为影响 （SEBI）研究项目，以了解SARS-COV-2感染模式并增加访问和 诊断方法在服务不足和/或弱势群体中的有效性。杜克临床研究 Institute（DCRI），UNC卫生公平研究中心（CHER）和社区校园合作伙伴关系 Health（CCPH）建议用作协调和数据收集中心（CDCC） RADX-UP联盟的管理，方向和整体协调。在一起，我们的多学科 项目协调经验； COVID-19思想领导力；监管科学；社区参与； 健康公平研究；社会正义；成人和儿童研究；统计数据;数据科学；和临床研究 信息学将推进RADX-UP计划中项目的目标。我们的总体目标是 实施以社区为中心的方法并建立有效，灵活，参与性和可持续性 CDCC将作为基础设施，以最大程度地提高项目在RADX-UP中的影响 程序。为了实现这一愿景，我们将建立一个由四个内核组成的程序框架。我们的 行政和协调核心与NIH科学人员合作，将促进 总体行政管理中的RADX-UP计划。 COVID-19测试核心将提供建议，并且 指南Covid-19测试协议；策划紧急测试数据；并管理快速试验研究 程序。社区和卫生系统参与核心将支持一个实践社区 RADX-UP计划；在交换各个社区的最佳实践方面提供支持， 参与和保留研究参与者；并协调研究结果的传播 RADX-UP项目。数据科学和生物统计学核心将管理数据收集，集成和 共享RADX-UP计划，包括合并和协调多个和多样的数据源 并提供数据标准，数据收集设计和生物统计学咨询服务。 RADX-UP CDCC 将使用既定的基础设施和主题专家实现目标，并将被定制以满足 RADX-UP社区的可变需求。使用最高的研究标准，我们的团队将 实现NIH在管理这一至关重要的协作努力方面设定的目标。