RADx-UP CDCC
RADx-UP CDCC
批准号:
10844144
负责人:
Michael Cohen-Wolkowiez
金额:
$1272.91万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-09-27 至 2025-06-30
关键词:
2019-nCoVAddressAdultBehavioralBiometryBiostatistics CoreCOVID-19COVID-19 disparityCOVID-19 morbidityCOVID-19 pandemicCOVID-19 pandemic effectsCOVID-19 testingCessation of lifeChildClinical ResearchCollaborationsCommunitiesCommunity of PracticeDataData CollectionData ScienceData SourcesDiagnostic ProcedureEffectivenessEnsureEquityEthicsFundingFutureGoalsHealthHealth systemInequalityInformaticsInfrastructureLeadershipOffice of Administrative ManagementOutcomeParticipantPatternPersonsPilot ProjectsPopulation ProgramsProtocols documentationPublic HealthRADx Underserved PopulationsResearchResearch InstituteResearch PersonnelResearch Project GrantsResearch SupportSARS-CoV-2 infectionScienceScientific Advances and AccomplishmentsServicesSocial JusticeTestingUnderserved PopulationUnited States National Institutes of HealthUniversitiesVirusVisionVulnerable PopulationsWorkcommunity centercommunity engaged researchcommunity engagementcommunity involvementdata managementdata repositorydata standardsdesigndisparity reductiondiverse dataexperienceflexibilityhealth disparityhealth equityimprovedinfrastructure developmentinterestlensmarginalized populationmortalitymultidisciplinarypandemic diseasepreventprogramsrecruitsocialstatistics
中文摘要
摘要
迫切需要减少与新冠肺炎相关的发病率和死亡率结果的差异
历史上被边缘化和脆弱的人群受到新冠肺炎大流行的影响不成比例。至
满足这一需求服务不足人群的快速诊断(RADx-UP)计划将
支持社区参与的测试研究项目以及对社会、伦理和行为的影响
(SEBI)研究项目,以了解SARS-CoV-2感染模式并增加获得和
诊断方法在服务不足和/或易受伤害人群中的有效性。杜克大学的临床研究
该研究所(DCRI)、北卡罗来纳大学卫生公平研究中心(CHER)和社区-校园伙伴关系
健康中心(CCPH)建议担任协调和数据收集中心,以提供
管理、指导和全面协调RADx-UP联合体。共同努力,我们的多学科
项目协调经验;新冠肺炎思维领导力;监管科学;社区参与;
健康公平研究;社会公正;成人和儿童研究;统计学;数据科学;和临床研究
信息学将推进RADx-Up计划中项目的目标。我们的首要目标是
实施以社区为中心的方法,建立有效、灵活、参与性和可持续的
CDCC将作为基础设施,最大限度地发挥RADx-UP项目的社区影响
程序。为了实现这一愿景,我们将建立一个由四个核心组成的计划框架。我们的
行政和协调核心将与国家卫生研究院的科学工作人员合作,促进
总体行政管理中的RADX-UP计划。新冠肺炎测试核心将提供建议和
指导新冠肺炎测试方案;整理紧急测试数据;管理快速试点研究
程序。社区和卫生系统参与核心将支持整个社区的实践
RADx-Up计划;在社区之间交流招聘最佳做法方面提供支持,
参与和保留研究参与者;协调研究结果的传播
RADX-UP项目。数据科学和生物统计核心将管理数据收集、集成和
共享RADx-UP计划,包括合并和协调多种不同的数据源
并提供数据标准、数据收集设计、生物统计咨询服务。RADx-UP CDCC
将使用已建立的基础设施和主题专家来实现目标,并将进行定制以满足
RADx-UP社区的各种需求。使用最高的研究标准,我们的团队将
完成美国国立卫生研究院在管理这一至关重要的合作努力方面设定的目标。
英文摘要
ABSTRACT
There is an urgent need to reduce disparities in COVID-19 associated morbidity and mortality outcomes in
historically marginalized and vulnerable populations disproportionately affected by the COVID-19 pandemic. To
address this need the Rapid Acceleration of Diagnostics for Underserved Populations (RADx-UP) program will
support Community-Engaged Testing Research Projects and Social, Ethical and Behavioral Implications
(SEBI) Research Projects to understand SARS-CoV-2 infection patterns and increase access and
effectiveness of diagnostic methods in underserved and/or vulnerable populations. The Duke Clinical Research
Institute (DCRI), the UNC Center for Health Equity Research (CHER), and Community-Campus Partnerships
for Health (CCPH) propose to serve as the Coordination and Data Collection Center (CDCC) to provide
management, direction, and overall coordination of the RADx-UP consortium. Together, our multidisciplinary
experience in project coordination; COVID-19 thought leadership; regulatory science; community engagement;
health equity research; social justice; adult and child research; statistics; data science; and clinical research
informatics will advance the objectives of the projects in the RADx-UP Program. Our overarching goal is to
implement a community-centered approach and establish an effective, flexible, participatory, and sustainable
CDCC that will serve as the infrastructure to maximize the community impact of projects in the RADx-UP
Program. To achieve this vision, we will establish a program framework comprised of four cores. Our
Administration and Coordination Core, in collaboration with NIH scientific staff, will facilitate the work of the
RADx-UP Program in overarching administrative management. The COVID-19 Testing Core will advise and
guide COVID-19 testing protocols; curate emergent testing data; and administer the Rapid Pilot Studies
Program. The Community and Health System Engagement Core will support a community of practice across
the RADx-UP Program; provide support in exchanging best practices across communities on recruitment,
engagement, and retention of study participants; and coordinate the dissemination of study findings from
RADx-UP projects. The Data Science and Biostatistics Core will manage data collection, integration, and
sharing for the RADx-UP Program including merging and harmonization of multiple and diverse data sources
and provide data standards, data collection design, and biostatistics consulting services. The RADx-UP CDCC
goals will be met using established infrastructure and subject matter experts and will be customized to meet
the variable needs of the RADx-UP community. Using the highest research standards, our team will
accomplish the goals set out by the NIH in managing this critically important collaborative effort.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
RADx-UP CDCC SAY YES COVID Test Study
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批准号:10366485
-
项目类别:
-
资助金额:$765.38万
-
财政年份:2020
-
负责人:Michael Cohen-Wolkowiez
-
依托单位:
RADx-UP CDCC
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批准号:10271490
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项目类别:
-
资助金额:$3624.34万
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财政年份:2020
-
负责人:Michael Cohen-Wolkowiez
-
依托单位:
RADx-UP CDCC
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批准号:10439479
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项目类别:
-
资助金额:$3236.41万
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财政年份:2020
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负责人:Michael Cohen-Wolkowiez
-
依托单位:
RADx-UP CDCC
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批准号:10854638
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项目类别:
-
资助金额:$200.0万
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财政年份:2020
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负责人:Michael Cohen-Wolkowiez
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依托单位:
RADx-UP SAY YES COVID Test Study (S4)
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批准号:10472985
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项目类别:
-
资助金额:$550.0万
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财政年份:2020
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负责人:Michael Cohen-Wolkowiez
-
依托单位:
Mentoring in Clinical Pharmacology and Early Phase Trials
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批准号:10394817
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项目类别:
-
资助金额:$17.77万
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财政年份:2019
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负责人:Michael Cohen-Wolkowiez
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依托单位:
Mentoring in Clinical Pharmacology and Early Phase Trials
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批准号:10620632
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项目类别:
-
资助金额:$17.77万
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财政年份:2019
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负责人:Michael Cohen-Wolkowiez
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依托单位:
Global Pediatric Clinical Trials Network
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批准号:10206152
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项目类别:
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资助金额:$100.0万
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财政年份:2017
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负责人:Michael Cohen-Wolkowiez
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依托单位:
Global Pediatric Clinical Trials Network
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批准号:9980849
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项目类别:
-
资助金额:$100.0万
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财政年份:2017
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负责人:Michael Cohen-Wolkowiez
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依托单位:
Physiologically-Based Pharmacokinetic Models for Optimal Drug Dosing in Children
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批准号:8661919
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项目类别:
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资助金额:$62.14万
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财政年份:2014
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负责人:Michael Cohen-Wolkowiez
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依托单位:
Physiologically-Based Pharmacokinetic Models for Optimal Drug Dosing in Children
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批准号:8901251
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项目类别:
-
资助金额:$67.69万
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财政年份:2014
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负责人:Michael Cohen-Wolkowiez
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依托单位:
Physiologically-Based Pharmacokinetic Models for Optimal Drug Dosing in Children
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批准号:9310077
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项目类别:
-
资助金额:$56.65万
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财政年份:2014
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负责人:Michael Cohen-Wolkowiez
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依托单位:
Clinical Practice Data to Aid Narrow Therapeutic Index Drug Classification
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批准号:8890533
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项目类别:
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资助金额:$24.99万
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财政年份:2013
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负责人:Michael Cohen-Wolkowiez
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依托单位:
Clinical Practice Data to Aid Narrow Therapeutic Index Drug Classification
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批准号:8662573
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项目类别:
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资助金额:$24.7万
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财政年份:2013
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负责人:Michael Cohen-Wolkowiez
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依托单位:
Pharmacokinetics and Pharmacodynamics of Antibiotics in Premature Infants
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批准号:8514953
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项目类别:
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资助金额:$12.0万
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财政年份:2010
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负责人:Michael Cohen-Wolkowiez
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依托单位:
Pharmacokinetics and Pharmacodynamics of Antibiotics in Premature Infants
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批准号:8129823
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项目类别:
-
资助金额:$11.83万
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财政年份:2010
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负责人:Michael Cohen-Wolkowiez
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依托单位:
Pharmacokinetics and Pharmacodynamics of Antibiotics in Premature Infants
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批准号:8305685
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项目类别:
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资助金额:$12.07万
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财政年份:2010
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负责人:Michael Cohen-Wolkowiez
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依托单位:
Pharmacokinetics and Pharmacodynamics of Antibiotics in Premature Infants
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批准号:7872599
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项目类别:
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资助金额:$11.55万
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财政年份:2010
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负责人:Michael Cohen-Wolkowiez
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依托单位:
海外基金