Energy Expenditure and Weight-Related Behaviors in Youth with Down Syndrome
患有唐氏综合症的青少年的能量消耗和体重相关行为
基本信息
- 批准号:10365057
- 负责人:
- 金额:$ 148.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-01 至 2023-11-30
- 项目状态:已结题
- 来源:
- 关键词:AccelerometerAddressAdultAgeAlgorithmsBehaviorBody Weight ChangesBody fatCaloriesCaregiversCharacteristicsClinical TrialsCross-Sectional StudiesDataData CollectionDiagnosisDietary intakeDisabled ChildrenDisabled PersonsDown SyndromeDyslipidemiasEnergy IntakeEnergy MetabolismEnrollmentEnsureEquationEquilibriumFamilyFatty acid glycerol estersFoundationsFrequenciesFundingFutureGrowthHealthHealth ProfessionalHeightHigh PrevalenceHourHyperinsulinismHypothyroidismImpairmentIndividualInvestigationLeptin resistanceLifeLife ExpectancyLinkMeasurementMeasuresMedical EconomicsMethodsModelingMorbidity - disease rateMuscle hypotoniaNational Institute of Child Health and Human DevelopmentNutrientObesityObstructive Sleep ApneaOrthopedicsOutcomeOutcome StudyParticipantPatternPhysical activityPhysiological ProcessesPilot ProjectsPopulationPrevalencePreventionProspective StudiesQuestionnairesRecommendationReportingResearchResearch PriorityRiskSamplingScienceSecureSelf ManagementSleepSocial isolationSpinal DysraphismVulnerable PopulationsWeightWeight maintenance regimenYouthbasecardiorespiratory fitnessclinical practicecohortcombatdietarydisabilitydoubly-labeled waterhealth managementhigh riskhigh risk behaviorhigh risk populationimprovednutritionobesity preventionobesity riskobesity treatmentpeerpreventpsychologicrecruitsedentarysextotal energy expenditurevirtual
项目摘要
The consequences of obesity are ominous, yet we are not adequately preventing or treating obesity in youth
with Down Syndrome (DS). In DS, obesity has been linked to adverse health outcomes. In addition, obesity
further limits one’s independence, ability to optimally function, self-manage health and creates additional
challenges for caregivers.
Total daily energy expenditure (TDEE) is the energy expended in a 24-hour period through physical activity
and physiologic processes. An individual’s TDEE is essential for determining daily caloric intake needed to
maintain or change body weight. Furthermore, TDEE is the foundation of anticipatory guidance provided by
health care professionals to optimize growth and weight management. Successful prevention and treatment of
obesity in youth with DS is severely compromised by the lack of accurate data on TDEE and information on
weight-related behaviors for this high-risk population.
This prospective, cross-sectional study will include a sample of 230 youth with DS, (stratified by age and sex).
Doubly Labeled Water (DLW) analysis will provide the criterion body fat%, fat-free mass and TDEE. Study
participants will be recruited nationally, utilizing DS-Connect® and DS family focused organizations. To
increase accessibility, support enrollment, and decrease burden on participants, all data collection will be
conducted virtually.
Using DLW, this study will, 1) examine and describe average TDEE based on age and sex, 2) develop a
prediction equation based on actual TDEE to predict energy requirements with a best-fit model based on fat-
free mass, sex, age, and height and/or weight, and 3) use 24-hour dietary recalls, a nutrition and physical
activity screener, accelerometers, and sleep questionnaire to describe the patterns and quality of dietary intake
and sleep and duration and frequency of physical activity in youth with DS. This will provide further
understanding of weight-related behaviors as obesity determinants, currently not well understood for this
population.
The lack of accurate information on energy expenditure and weight-related behaviors in youth with DS
significantly impedes successful prevention and treatment of obesity for this vulnerable population. Findings
from the proposed study will advance the science of weight management in individuals with disabilities,
address national research priorities, and shift clinical practice paradigms.
肥胖的后果是不祥的,但我们没有充分预防或治疗青年肥胖症
唐氏综合症(Down Syndrome,DS)在DS中,肥胖与不良健康结果有关。此外,肥胖
进一步限制了一个人的独立性,最佳功能,自我管理健康的能力,并创造了额外的
照顾者的挑战。
每日总能量消耗(TDEE)是指24小时内通过体力活动消耗的能量
和生理过程。一个人的TDEE是必不可少的,以确定每日所需的热量摄入,
保持或改变体重。此外,TDEE是由以下方面提供的预期指导的基础:
健康护理专业人员优化生长和体重管理。成功预防和治疗
由于缺乏关于TDEE的准确数据和以下信息,
与体重相关的行为。
这项前瞻性的横断面研究将包括230名DS青年的样本(按年龄和性别分层)。
双标记水(DLW)分析将提供标准体脂%、去脂质量和TDEE。研究
参与者将在全国范围内招募,利用DS-Connect®和DS家庭为重点的组织。到
增加可访问性,支持入组,并减少参与者的负担,所有数据收集将
虚拟地进行。
使用DLW,本研究将:1)检查和描述基于年龄和性别的平均TDEE,2)开发一个
基于实际TDEE的预测方程,以基于脂肪的最佳拟合模型预测能量需求,
自由质量,性别,年龄,身高和/或体重,和3)使用24小时饮食召回,营养和物理
活动筛选器、加速度计和睡眠问卷,以描述饮食摄入的模式和质量
以及睡眠和体力活动的持续时间和频率。这将进一步提供
了解与体重相关的行为是肥胖的决定因素,目前还没有很好地了解这一点
人口
缺乏关于DS青年能量消耗和体重相关行为的准确信息
严重阻碍了成功预防和治疗这一脆弱人群的肥胖症。结果
从拟议的研究将推进科学的体重管理的个人残疾,
解决国家研究重点,并改变临床实践模式。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Michele Polfuss其他文献
Michele Polfuss的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Michele Polfuss', 18)}}的其他基金
Body Composition and Energy Expenditure in Youth with Spina Bifida
脊柱裂青少年的身体成分和能量消耗
- 批准号:
10529266 - 财政年份:2019
- 资助金额:
$ 148.58万 - 项目类别:
Pilot Project 1: Weight-Related Self-Management in Children with Special Health Care Needs
试点项目 1:有特殊医疗保健需求的儿童的体重相关自我管理
- 批准号:
8821508 - 财政年份:
- 资助金额:
$ 148.58万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 148.58万 - 项目类别:
Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 148.58万 - 项目类别:
Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 148.58万 - 项目类别:
Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 148.58万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 148.58万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 148.58万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 148.58万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 148.58万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 148.58万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 148.58万 - 项目类别:
Research Grant