Medical University of South Carolina Transdisciplinary Collaborative Center in Precision Medicine and Minority Men's Health

南卡罗来纳医科大学精准医学和少数族裔男性健康跨学科合作中心

• 批准号: 10507885
• 负责人: STEPHEN P. ETHIER
• 金额: $ 132.59万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-08 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10507885
• 关键词: Medical; University; South; Carolina; Transdisciplinary

 DESCRIPTION (provided by applicant): The overarching goal of the Medical University of South Carolina (MUSC) Transdisciplinary Collaborative Center (TCC) in Precision Medicine for Minority Men's Health is to determine the most effective ways to integrate, interpret, and apply biological, social, psychological, and clinical determinants of disease risks and outcomes into more precise medical strategies to prevent, diagnose, and treat chronic health conditions and diseases. To accomplish this goal, the MUSC TCC will: (1) utilize a multi-regional consortium network representing academic medical centers, community-based health organizations, public health agencies, and community stakeholders who will continually shape research priorities and strategies by embracing the principles of community-based participatory research; (2) conduct novel transdisciplinary research examining the synergistic effects of the multi-level, individual-specific characteristics that impact disease risks and outcomes; and (3) determine and disseminate best practices for delivering precision medicine-based care in an effort to reverse health care disparities among minority men in different clinical and community settings. Center partners will include NIMHD-funded centers at the University of Pennsylvania, Hampton University, and the University of Texas Health Sciences Center, San Antonio as well as forefront thought-leaders in minority health from the Hope Institute, the National Black Leadership Initiative on Cancer, Southeast Health Equity Council, and regional HRSA-funded Area Health Education Centers. Key elements of the MUSC TCC organizational structure include a well-defined academic home at MUSC with synergistic health disparity- focused missions and support from an NCI-designated Cancer Center and an NCATS-funded Clinical and Translational Science Award; three initial precision medicine research projects linked by a novel theoretical framework; a Data Integration Core led by nationally-recognized bioinformatic and medical informatic experts charged with creating integrated data sets that include clinical health outcomes data, biospecimen data, and data on social, psychological, and behavioral determinants; an Implementation Core that will deploy the latest approaches in dissemination research through the use of regional Evidence Academies; and a governance structure comprised of three highly qualified multi-PIs with expertise in health disparities, precision medicine, and translational medicine who set the tone for the transdisciplinary underpinnings of this TCC. The MUSC TCC and its partners across Health and Human Services Regions III, IV, and VI are poised to significantly impact the health outcomes of minority men throughout their regional communities utilizing innovative precision medicine-based insights and interventions.

 描述(由申请人提供)：南卡罗来纳医科大学(MUSC)跨学科合作中心(TCC)在少数民族男性健康精准医学领域的首要目标是确定最有效的方法，将疾病风险和结果的生物、社会、心理和临床决定因素整合、解释和应用到更精确的医疗策略中，以预防、诊断和治疗慢性健康状况和疾病。为了实现这一目标，MUSC TCC将：(1)利用一个由学术医疗中心、社区卫生组织、公共卫生机构和社区利益相关者组成的多地区联盟网络，他们将遵循以社区为基础的参与性研究的原则，继续形成研究的优先事项和战略；(2)进行新颖的跨学科研究，研究影响疾病风险和结果的多层次、特定个体特征的协同效应；以及(3)确定和传播提供精准医疗保健的最佳实践，努力扭转不同临床和社区环境中少数族裔男性之间的医疗差距。该中心的合作伙伴将包括宾夕法尼亚大学、汉普顿大学和圣安东尼奥的德克萨斯大学健康科学中心由NIMHD资助的中心，以及来自希望研究所、全国癌症黑人领导倡议、东南健康公平委员会和地区HRSA资助的地区健康教育中心的少数群体健康领域的前沿思想领袖。MUSC TCC组织结构的关键要素包括：在MUSC有一个明确的学术之家，具有协同健康差异的任务，并得到NCI指定的癌症中心和NCATS资助的临床和翻译科学奖的支持；三个由新的理论框架连接的初始精确医学研究项目；由国家公认的生物信息学和医学信息学专家领导的数据集成核心，负责创建综合数据集，其中包括临床健康结果数据、生物样本数据以及社会、心理和行为决定因素的数据；实施核心，将通过使用区域证据学院部署传播研究的最新方法；治理结构由三名具有健康差距、精准医学和转化医学专业知识的高素质多元个人组成，他们为这一TCC的跨学科基础奠定了基调。MUSC TCC及其在卫生和公共服务区III、IV和VI的合作伙伴准备利用基于精确医学的创新见解和干预措施，显著影响整个地区社区少数族裔男性的健康结果。

项目成果

miRNA-Mediated Priming of Macrophage M1 Differentiation Differs in Gram-Positive and Gram-Negative Settings.

• DOI: 10.3390/genes13020211
• 发表时间: 2022-01-24
• 期刊: Genes
• 影响因子: 3.5
• 作者: Riechert G;Maucher D;Schmidt B;Schumann J
• 通讯作者: Schumann J

Automating a Process Convolution Approach to Account for Spatial Information in Imaging Mass Spectrometry Data.

自动处理卷积方法来解释成像质谱数据中的空间信息。

• DOI: 10.1016/j.spasta.2020.100422
• 发表时间: 2020
• 期刊: Spatial statistics
• 影响因子: 2.3
• 作者: Miller,Cameron;Lawson,Andrew;Chung,Dongjun;Gebregziabher,Mulugeta;Yeh,Elizabeth;Drake,Richard;Hill,Elizabeth
• 通讯作者: Hill,Elizabeth

New Enzymatic Approach to Distinguish Fucosylation Isomers of N-Linked Glycans in Tissues Using MALDI Imaging Mass Spectrometry.

• DOI: 10.1021/acs.jproteome.0c00024
• 发表时间: 2020-08-07
• 期刊: Journal of proteome research
• 影响因子: 4.4
• 作者: West CA;Liang H;Drake RR;Mehta AS
• 通讯作者: Mehta AS

Transcriptome Profiling Reveals Enhanced Mitochondrial Activity as a Cold Adaptive Strategy to Hypothermia in Zebrafish Muscle.

• DOI: 10.3390/cells12101366
• 发表时间: 2023-05-11
• 期刊: CELLS
• 影响因子: 6
• 作者: Cahill, Thomas;Chan, Sherine;Overton, Ian M.;Hardiman, Gary
• 通讯作者: Hardiman, Gary

Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model.

• DOI: 10.3390/cells10040906
• 发表时间: 2021-04-14
• 期刊: Cells
• 影响因子: 6
• 作者: Cahill T;da Silveira WA;Renaud L;Williamson T;Wang H;Chung D;Overton I;Chan SSL;Hardiman G
• 通讯作者: Hardiman G