Medical University of South Carolina Transdisciplinary Collaborative Center in Precision Medicine and Minority Men's Health

 描述（由申请人提供）：南卡罗来纳医科大学 (MUSC) 少数族裔男性健康精准医学跨学科合作中心 (TCC) 的总体目标是确定最有效的方法，将疾病风险和结果的生物、社会、心理和临床决定因素整合、解释和应用到更精确的医疗策略中，以预防、诊断和治疗慢性健康状况和疾病。为了实现这一目标，MUSC TCC 将：（1）利用代表学术医疗中心、社区卫生组织、公共卫生机构和社区利益相关者的多区域联盟网络，他们将通过接受基于社区的参与性研究的原则，不断制定研究重点和战略； (2) 开展新颖的跨学科研究，检验影响疾病风险和结果的多层次、个体特异性特征的协同效应； (3) 确定并传播提供精准医疗护理的最佳实践，以努力扭转不同临床和社区环境中少数族裔男性之间的医疗保健差异。中心合作伙伴将包括 NIMHD 资助的宾夕法尼亚大学、汉普顿大学和圣安东尼奥德克萨斯大学健康科学中心的中心，以及来自希望研究所、全国黑人癌症领导力倡议、东南健康公平委员会和 HRSA 资助的地区健康教育中心的少数族裔健康领域的前沿思想领袖。 MUSC TCC 组织结构的关键要素包括 MUSC 内一个明确的学术中心，其使命是协同促进健康差异，并得到 NCI 指定的癌症中心和 NCATS 资助的临床和转化科学奖的支持；由新颖的理论框架联系起来的三个初始精准医学研究项目；由国家认可的生物信息学和医学信息学专家领导的数据集成核心，负责创建集成数据集，包括临床健康结果数据、生物样本数据以及社会、心理和行为决定因素的数据；一个实施核心，将通过使用区域证据学院部署传播研究的最新方法；治理结构由三位高素质的多PI组成，他们在健康差异、精准医学和转化医学方面拥有专业知识，他们为该TCC的跨学科基础定下了基调。 MUSC TCC 及其在卫生和人类服务区域 III、IV 和 VI 的合作伙伴准备利用基于创新精准医学的见解和干预措施，对整个区域社区的少数族裔男性的健康结果产生重大影响。

 DESCRIPTION (provided by applicant): The overarching goal of the Medical University of South Carolina (MUSC) Transdisciplinary Collaborative Center (TCC) in Precision Medicine for Minority Men's Health is to determine the most effective ways to integrate, interpret, and apply biological, social, psychological, and clinical determinants of disease risks and outcomes into more precise medical strategies to prevent, diagnose, and treat chronic health conditions and diseases. To accomplish this goal, the MUSC TCC will: (1) utilize a multi-regional consortium network representing academic medical centers, community-based health organizations, public health agencies, and community stakeholders who will continually shape research priorities and strategies by embracing the principles of community-based participatory research; (2) conduct novel transdisciplinary research examining the synergistic effects of the multi-level, individual-specific characteristics that impact disease risks and outcomes; and (3) determine and disseminate best practices for delivering precision medicine-based care in an effort to reverse health care disparities among minority men in different clinical and community settings. Center partners will include NIMHD-funded centers at the University of Pennsylvania, Hampton University, and the University of Texas Health Sciences Center, San Antonio as well as forefront thought-leaders in minority health from the Hope Institute, the National Black Leadership Initiative on Cancer, Southeast Health Equity Council, and regional HRSA-funded Area Health Education Centers. Key elements of the MUSC TCC organizational structure include a well-defined academic home at MUSC with synergistic health disparity- focused missions and support from an NCI-designated Cancer Center and an NCATS-funded Clinical and Translational Science Award; three initial precision medicine research projects linked by a novel theoretical framework; a Data Integration Core led by nationally-recognized bioinformatic and medical informatic experts charged with creating integrated data sets that include clinical health outcomes data, biospecimen data, and data on social, psychological, and behavioral determinants; an Implementation Core that will deploy the latest approaches in dissemination research through the use of regional Evidence Academies; and a governance structure comprised of three highly qualified multi-PIs with expertise in health disparities, precision medicine, and translational medicine who set the tone for the transdisciplinary underpinnings of this TCC. The MUSC TCC and its partners across Health and Human Services Regions III, IV, and VI are poised to significantly impact the health outcomes of minority men throughout their regional communities utilizing innovative precision medicine-based insights and interventions.