Bayesian Data-Driven Subject-Specific Modeling of Voice Production

贝叶斯数据驱动的语音产生的特定主题建模

• 批准号: 10360108
• 负责人: Maryam Naghibolhosseini
• 金额: $ 18.8万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10360108
• 关键词: Acoustics; Address; Adult; Affect; Air Movements; Area; Award; Bayesian Analysis; Bayesian Modeling; Behavior; Biomechanics; Biophysical Process; Characteristics; Communication; Complex; Computer Models; Coupled; Coupling; Data; Diagnosis; Disease; Edema; Elements; Functional disorder; Future; Goals; Health; Human; Hybrids; Individual; Kinetics; Knowledge; Laryngitis; Larynx; Liquid substance; Lung; Measurement; Methods; Modeling; National Institute on Deafness and Other Communication Disorders; Nature; Noise; Normal Range; Operative Surgical Procedures; Oral cavity; Outcome; Outcome Study; Outcomes Research; Participant; Pathologic; Pathology; Patients; Pattern; Phonation; Polyps; Prevention; Probability; Production; Property; Research; Research Personnel; Signal Transduction; Speed; Strategic Planning; Structure; System; Techniques; Tissues; Treatment Efficacy; Uncertainty; Validation; Voice; Voice Disorders; design; efficacy evaluation; human data; improved; in vivo; individual patient; kinematics; model design; novel strategies; predictive modeling; simulation; tool; vibration; vocal cord

Project Summary/Abstract This proposal aims to develop Bayesian subject-specific computational models of voice production in vocally normal individuals and patients with structural voice disorders. Voice production is a complex biophysical process, consisting of vocal fold biomechanics and sub-glottal, intra-glottal, and supra-glottal aerodynamics, as well as their interactions. Predictive computational modeling approaches are highly needed as they provide scientific tools for better understanding the detailed function of such a sophisticated coupled system. They can be employed to study the normal function of voice production and investigate how it can be impacted due to an anomaly or malfunction in the vocal fold structure or behavior. Experimental data of high-speed videoendoscopy, electroglottography and acoustic signals will be used to design computational models of voice production, coupling laryngeal dynamics and aerodynamics. In Aim 1, the objective is to develop Bayesian predictive models that can capture the uncertainties inherent in the data and models. The Bayesian inference will be performed using the high-speed videoendoscopy and electroglottography data. The models will be validated with acoustic signals for each vocally normal participant. The model will couple the vocal fold tissue vibration (kinetics and kinematics) with the instantaneously interacting aerodynamics of glottal airflow to take into account the flow- structure interaction during phonation. In Aim 2, the goal is to design patient-specific computational models of voice production for patients with structural voice pathologies including vocal polyps, Reinke's edema, and laryngitis. The assumption is that the vocal fold vibrations can be forced and fluid-induced in the patients. An external patient-specific force component will be calculated from the model for the patients, where the physical structure and vibratory behavior of the vocal folds are negatively impacted by the pathology. The parameter uncertainties will be calculated and expected to vary greatly among the patients due to the disorders. The outcome of this research will extend and deepen our understanding of the normal voice function and pathophysiology of voice disorders. The proposed research is in harmony with multiple priority areas described in the 2017-2021 Strategic Plan of the NIDCD [3]. Aim 1 supports Priority 1 (“deepen our understanding of the normal function of the systems of human communication”) by designing computational models of voice production for norm. Aim 2 proposes to determine vocal dynamics and glottal aerodynamics of voice production in patients with structural voice disorders, which addresses Priority 2 (“increase our knowledge about conditions that alter or diminish communication and health”). Both Aims support Priority 3 (“improve methods of diagnosis, treatment, and prevention”) through determining what laryngeal mechanisms are disrupted in patients with voice disorder and how it affects the acoustic signal.

项目概要/摘要 该提案旨在开发声音产生的贝叶斯特定主题计算模型 正常人和患有结构性发声障碍的患者。发声是一个复杂的生物物理过程 过程，包括声带生物力学和声门下、声门内和声门上空气动力学，如 以及他们的互动。预测计算建模方法是非常需要的，因为它们提供了 更好地理解这种复杂耦合系统的详细功能的科学工具。他们可以 用于研究发声的正常功能，并研究它如何受到以下影响： 声带结构或行为异常或功能障碍。高速视频内窥镜实验数据， 电声门描记术和声学信号将用于设计声音产生的计算模型， 耦合喉部动力学和空气动力学。目标 1 的目标是开发贝叶斯预测模型 可以捕捉数据和模型固有的不确定性。将执行贝叶斯推理 使用高速视频内窥镜检查和电声门描记数据。该模型将通过声学验证 每个声音正常的参与者的信号。该模型将耦合声带组织振动（动力学和 运动学）与声门气流的瞬时相互作用的空气动力学考虑到流动 发声过程中的结构相互作用。目标 2 的目标是设计患者特定的计算模型 为患有结构性嗓音疾病（包括声带息肉、赖因克氏水肿和声带息肉）的患者提供发声服务 喉炎。假设患者的声带振动可以是受迫的和液体引起的。一个 外部患者特定的力分量将根据患者的模型进行计算，其中物理 声带的结构和振动行为受到病理学的负面影响。参数 由于疾病的原因，不确定性将被计算并预计在患者之间会有很大差异。这 这项研究的成果将扩展和加深我们对正常语音功能和 声音障碍的病理生理学。拟议的研究与描述的多个优先领域相一致 NIDCD 2017-2021 年战略计划[3]。目标 1 支持优先事项 1（“加深我们对 人类通信系统的正常功能”）通过设计语音计算模型 生产达标。目标 2 提出确定发声的声音动力学和声门空气动力学 患有结构性嗓音障碍的患者，它解决了优先事项 2（“增加我们对疾病的了解”） 改变或削弱沟通和健康”）。这两个目标都支持优先级 3（“改进诊断方法、 治疗和预防”）通过确定声音患者的哪些喉部机制受到干扰 紊乱及其如何影响声音信号。