Impact of the COVID-19 pandemic on newly-diagnosed breast cancer

COVID-19 大流行对新诊断乳腺癌的影响

基本信息

  • 批准号:
    10359555
  • 负责人:
  • 金额:
    $ 7.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-01-01 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

The COVID-19 pandemic resulted in dramatic reductions in use of breast cancer screening and diagnostic services, with screening mammography plunging by up to 99% at the lowest point. Screening and other diagnostic delays have the potential to result in shifts in the population distribution of breast cancer characteristics, resulting in tumors that are larger, higher grade, and more often lymph node positive – all factors associated with increased breast cancer mortality. In observational studies, these effects were more pronounced among Black and premenopausal women, suggesting that pandemic-related changes in the distribution of breast cancer characteristics could worsen existing breast cancer disparities. Despite this emerging evidence, there is little real-world data that quantifies the magnitude of the delay’s effects on the epidemiology of breast cancer. This lack of information inhibits the ability to develop systematic, evidence-based interventions that might reduce excess deaths. Therefore, the objective of this study is to measure the pandemic’s impact on the epidemiology of breast cancer, using data from 3,780 women diagnosed with breast cancer at University of North Carolina (UNC) Medical Center, UNC Rex, and Nash UNC hospitals during the pandemic (March 2020- November 2021), compared to 8,947 breast cancer patients diagnosed at the same hospitals before the pandemic (March 2015-February 2020). The underlying hypothesis is that overall breast cancer incidence declined following the pandemic onset, but that among the breast cancers that were diagnosed tumors with poor prognostic characteristics were over-represented. The hypothesis will be evaluated by pursuing the following specific aims: (1) evaluating pandemic vs. pre-pandemic changes in breast cancer incidence by comparing incidence overall and according to prognostic characteristics (e.g., stage at diagnosis, tumor size, tumor grade, lymph node status, breast cancer subtype); and (2) evaluating pandemic vs. pre-pandemic differences in breast cancer incidence according to indicators of socioeconomic status (e.g., area deprivation index, health insurance status) and patient factors associated with breast cancer survival disparities (age, race/ethnicity). These trends will be evaluated using interrupted time series analysis, a methodologically rigorous approach that allows for the control of pre-pandemic trends while testing for an effect of the intervention. Patient cancer diagnosis and personal information will be obtained from hospital cancer registries, which abstract high-quality, standardized data ~6 months before similar data become publicly available through other sources (e.g., state cancer registry), allowing for the timely identification of changes in breast cancer incidence patterns. Evaluating the pandemic’s impact on the epidemiology of breast cancer will facilitate identification of interventions (e.g., modifications to the diagnostic process, targeting of affected demographic subgroups to decrease loss to follow-up, etc.) to alleviate the impact of pandemic-related delays in care and reduce the number of excess breast cancer deaths attributable to the pandemic.
2019冠状病毒病大流行导致乳腺癌筛查和诊断的使用大幅减少

项目成果

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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Sarah Jane Nyante其他文献

Sarah Jane Nyante的其他文献

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{{ truncateString('Sarah Jane Nyante', 18)}}的其他基金

Breast cancer neoadjuvant endocrine therapy during the Covid-19 pandemic: Opportunity for a new treatment paradigm?
Covid-19大流行期间的乳腺癌新辅助内分泌治疗:新治疗模式的机会?
  • 批准号:
    10425018
  • 财政年份:
    2022
  • 资助金额:
    $ 7.78万
  • 项目类别:
Impact of the COVID-19 pandemic on newly-diagnosed breast cancer
COVID-19 大流行对新诊断乳腺癌的影响
  • 批准号:
    10544316
  • 财政年份:
    2022
  • 资助金额:
    $ 7.78万
  • 项目类别:
Breast cancer neoadjuvant endocrine therapy during the Covid-19 pandemic: Opportunity for a new treatment paradigm?
Covid-19大流行期间的乳腺癌新辅助内分泌治疗:新治疗模式的机会?
  • 批准号:
    10589922
  • 财政年份:
    2022
  • 资助金额:
    $ 7.78万
  • 项目类别:
Understanding the biological basis for the association between parenchymal texture features and breast cancer risk
了解实质纹理特征与乳腺癌风险之间关联的生物学基础
  • 批准号:
    10697306
  • 财政年份:
    2019
  • 资助金额:
    $ 7.78万
  • 项目类别:
Understanding the biological basis for the association between parenchymal texture features and breast cancer risk
了解实质纹理特征与乳腺癌风险之间关联的生物学基础
  • 批准号:
    10241446
  • 财政年份:
    2019
  • 资助金额:
    $ 7.78万
  • 项目类别:
Understanding the biological basis for the association between parenchymal texture features and breast cancer risk
了解实质纹理特征与乳腺癌风险之间关联的生物学基础
  • 批准号:
    10472712
  • 财政年份:
    2019
  • 资助金额:
    $ 7.78万
  • 项目类别:
Understanding the biological basis for the association between parenchymal texture features and breast cancer risk
了解实质纹理特征与乳腺癌风险之间关联的生物学基础
  • 批准号:
    9975109
  • 财政年份:
    2019
  • 资助金额:
    $ 7.78万
  • 项目类别:

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