Rationale for the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) at Children?s National

国家儿童医院儿科血液学和输血医学多学科研究培训奖 (PHTMMRT) 的理由

• 批准号: 10360585
• 负责人: Catherine M. Bollard
• 金额: $ 12.39万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10360585
• 关键词: Award; Child; Interdisciplinary Study; Pediatric Hematology; Research Training; transfusion medicine

The rationale for this renewal application is to continue our highly collaborative and multidisciplinary, inter- institutional program of mentored training for future scientists in pediatric transfusion medicine and hematology. Our objective is to address the barriers for the conduct of high quality and transformative research in pediatric transfusion medicine and hematology including: 1) lack of a robust infrastructure for research training and implementation; 2) shortage of mid-career and senior investigators to serve as research mentors; 3) need for multidisciplinary translational approaches to answer critical clinical questions; 4) lack of diversity among clinical and translational investigators. This program is focused on advancing clinical and translational scholarship on the diagnosis and clinical management of hematological, cardiovascular and pulmonary disorders, transfusion, cell therapy and transplantation. The design of the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) is focused on preparing trainees from diverse backgrounds for academic leadership and independently funded research careers. Each trainee in the program completes a Master's in Clinical and Translational Science (MsCTR) at the George Washington University (GWU) School of Medicine and Health Sciences or equivalent, and will devise, implement and complete a research project under the joint oversight of a multidisciplinary mentorship team. At the completion of the two- to three-year program, each trainee will have presented his/her data to at least one national research meeting, drafted and submitted one or more manuscripts suitable for external peer-reviewed publications, and for those in a three-year program, submitted an external grant application to the NIH or equivalent funding source. The program is overseen by two NIH-funded Principal Investigators with complementary clinical and research expertise, supported by nine faculty of Children's National and GWU, with four external mentors. All mentors are research scientists with expertise in coagulation, transfusion medicine, cell therapy, transplantation, vascular biology and genomic/proteomics. A Diversity Enhancement Officer will assist in the recruitment of minority, disabled or disadvantaged applicants, and women. Finally, an External Advisory Committee of four NIH-funded national leaders in transfusion medicine, transplantation and hematology with established career mentorship programs will offer annual feedback and guidance of the PHTMMRT program and the trainees' progress. The PHTMMRT program will leverage several of Children's National's multiple and pre-existing strengths with collaborating neighboring research institutions including the NIH, GWU and Howard University School of Medicine (HUSM). In summary, our multidisciplinary, inter-institutional mentors will train four to five future academic leaders in Pediatric Hematology/Transfusion Medicine including a focus on cell-based therapies for heart, lung and blood diseases.

这一更新申请的理由是继续我们的高度合作和多学科，跨- 为儿科输血医学和血液学未来科学家提供指导培训的机构计划。 我们的目标是解决在儿科进行高质量和变革性研究的障碍 输血医学和血液学包括：1）缺乏强大的研究培训基础设施， 2）缺乏担任研究导师的中级和高级调查员; 3）需要 多学科翻译方法来回答关键的临床问题; 4）临床之间缺乏多样性 和翻译研究人员。该计划的重点是推进临床和翻译奖学金， 血液、心血管和肺部疾病的诊断和临床管理，输血， 细胞疗法和移植。《儿科血液学与输血学》课程设计 多学科研究培训奖（PHTMMRT）的重点是准备学员从不同的 学术领导和独立资助的研究事业的背景。项目中的每个学员 在乔治华盛顿大学完成临床和转化科学（MsCTR）硕士学位 (GWU)医学与健康科学学院或同等学历，并将设计、实施和完成 在多学科指导小组的联合监督下开展研究项目。在完成两个- 到三年计划，每个受训者将至少向一次国家研究会议提交他/她的数据， 起草并提交了一份或多份适合外部同行评审出版物的手稿， 在一个为期三年的项目中，向NIH或同等资金来源提交了外部赠款申请。的 该项目由两名NIH资助的主要研究者监督，他们具有互补的临床和研究 专业知识，由儿童的国家和GWU的九个教师的支持，与四个外部导师。所有导师 是研究科学家，在凝血，输血医学，细胞治疗，移植， 血管生物学和基因组学/蛋白质组学。多样性促进干事将协助征聘 少数族裔、残疾人或弱势群体申请人以及妇女。最后，一个由四人组成的外部咨询委员会 NIH资助的输血医学，移植和血液学领域的国家领导人，具有既定的职业生涯 导师计划将提供PHTMMRT计划的年度反馈和指导， 中求进工作总PHTMMRT计划将利用儿童国家的多个和预先存在的几个 与包括NIH、GWU和霍华德大学在内的邻近研究机构合作的优势 医学院（HUSM）。总之，我们的多学科，跨机构的导师将培训四到五个 儿科血液学/输血医学的未来学术领导者，包括专注于基于细胞的 治疗心脏、肺和血液疾病。