Rationale for the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) at Children?s National

国家儿童医院儿科血液学和输血医学多学科研究培训奖 (PHTMMRT) 的理由

• 批准号: 9417175
• 负责人: Catherine M. Bollard
• 金额: $ 8.12万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9417175
• 关键词: Award; Child; Interdisciplinary Study; Medicine; Pediatric Hematology; Research Training; Transfusion

The rationale for this renewal application is to continue our highly collaborative and multidisciplinary, inter- institutional program of mentored training for future scientists in pediatric transfusion medicine and hematology. Our objective is to address the barriers for the conduct of high quality and transformative research in pediatric transfusion medicine and hematology including: 1) lack of a robust infrastructure for research training and implementation; 2) shortage of mid-career and senior investigators to serve as research mentors; 3) need for multidisciplinary translational approaches to answer critical clinical questions; 4) lack of diversity among clinical and translational investigators. This program is focused on advancing clinical and translational scholarship on the diagnosis and clinical management of hematological, cardiovascular and pulmonary disorders, transfusion, cell therapy and transplantation. The design of the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) is focused on preparing trainees from diverse backgrounds for academic leadership and independently funded research careers. Each trainee in the program completes a Master's in Clinical and Translational Science (MsCTR) at the George Washington University (GWU) School of Medicine and Health Sciences or equivalent, and will devise, implement and complete a research project under the joint oversight of a multidisciplinary mentorship team. At the completion of the two- to three-year program, each trainee will have presented his/her data to at least one national research meeting, drafted and submitted one or more manuscripts suitable for external peer-reviewed publications, and for those in a three-year program, submitted an external grant application to the NIH or equivalent funding source. The program is overseen by two NIH-funded Principal Investigators with complementary clinical and research expertise, supported by nine faculty of Children's National and GWU, with four external mentors. All mentors are research scientists with expertise in coagulation, transfusion medicine, cell therapy, transplantation, vascular biology and genomic/proteomics. A Diversity Enhancement Officer will assist in the recruitment of minority, disabled or disadvantaged applicants, and women. Finally, an External Advisory Committee of four NIH-funded national leaders in transfusion medicine, transplantation and hematology with established career mentorship programs will offer annual feedback and guidance of the PHTMMRT program and the trainees' progress. The PHTMMRT program will leverage several of Children's National's multiple and pre-existing strengths with collaborating neighboring research institutions including the NIH, GWU and Howard University School of Medicine (HUSM). In summary, our multidisciplinary, inter-institutional mentors will train four to five future academic leaders in Pediatric Hematology/Transfusion Medicine including a focus on cell-based therapies for heart, lung and blood diseases.

此次续订申请的基本原理是继续我们高度协作和多学科、 为未来的儿科输血医学和血液学科学家提供辅导性培训的机构计划。 我们的目标是解决在儿科进行高质量和变革性研究的障碍 输血医学和血液学包括：1)缺乏强有力的研究、培训和基础设施 执行；2)缺少职业生涯中期和高级调查人员担任研究导师；3)需要 回答关键临床问题的多学科翻译方法；4)临床中缺乏多样性 和翻译调查员。该计划的重点是促进临床和翻译方面的学术研究 血液、心血管和肺部疾病的诊断和临床处理，输血， 细胞治疗和移植。儿科血液学与输血学课程的设计 多学科研究培训奖(PHTMMRT)的重点是培养来自不同领域的学员 学术领导背景和独立资助的研究事业。计划中的每一位实习生 在乔治华盛顿大学完成临床和翻译科学硕士学位(MsCTR (GWU)医学和健康科学学院或同等学力，并将制定、实施和完成 在一个多学科指导团队的共同监督下进行的研究项目。在两项工程完成时- 对于三年计划，每个受训人员将至少向一次全国研究会议提交他/她的数据， 起草并提交了一份或多份适合外部同行审查出版物的手稿 在一个为期三年的计划中，向美国国立卫生研究院或同等资金来源提交了外部拨款申请。这个 该计划由两名由美国国立卫生研究院资助的首席研究人员监督，具有互补的临床和研究 专业知识，由国立儿童基金会和格拉斯哥大学的九名教职员工提供支持，并有四名外部导师。所有导师 是在凝血，输血医学，细胞治疗，移植， 血管生物学和基因组/蛋白质组学。一名促进多样性干事将协助招聘 少数族裔、残疾人或弱势群体申请者以及妇女。最后，一个由四人组成的外部咨询委员会 美国国立卫生研究院资助的国家输血医学、移植和血液学领域的领先者 导师计划将为PHTMMRT计划和受训者提供年度反馈和指导 进步。PHTMMRT计划将利用几个儿童国家的多重和预先存在的 与邻近研究机构合作的优势，包括NIH、GWU和Howard University 医学院(HUSM)。总而言之，我们的多学科、跨机构的导师将培训四到五名 未来儿科血液学/输血医学的学术领袖，包括细胞为基础的研究 心脏、肺和血液疾病的治疗。