Developmental Determination of Central Auditory Physiology by the Inner Ear

内耳中枢听觉生理学的发育决定

基本信息

  • 批准号:
    10365728
  • 负责人:
  • 金额:
    $ 36.73万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-05-01 至 2027-04-30
  • 项目状态:
    未结题

项目摘要

Project Summary: A longstanding and fundamental question of neural development in sensory pathways is: What is the role of the organization of the sensory epithelium in establishing central topographic organization? In the auditory system a direct approach to addressing this question has been elusive because it has not been possible to manipulate the input to the brain from the auditory periphery without either complete ablation of the inner ear or induction of hearing dysfunction. The proposed experiments will establish for the first time, a model of repatterned frequency representation in the chick inner ear by utilizing a new genetic manipulation in embryos. This manipulation takes advantage of the known genetic factors that establish the organization of the ear at a very early developmental stage that precedes the auditory nerve innervation of the central nervous system. By overexpressing one of these factors, bone morphogenic protein 7 (BMP7), inner ears develop almost exclusively low frequency hair cell phenotypes. In the first brain structure to receive auditory nerve input, the cochlear nucleus, neurons express a number of well characterized biophysical and morphological specializations for processing sound in specific frequencies. Frequency specific tuning is topographically mapped in both the ear and auditory brain regions, a feature known as 'tonotopy.' Thus, neural specialization occurs along an orderly tonotopic map in the cochlear nucleus. The central hypothesis of this proposal is that tonotopic refinement of specializations in the cochlear nucleus is developmentally determined by patterned input from the inner ear, and is not independently induced by local cues in the developing brain. This hypothesis is now testable using animals with tonotopically altered inner ears. The first aim of this proposal is to examine whether the BMP7 manipulation indeed induces repatterning of hair cell tuning mechanism in the inner ear. The second aim investigates the electrical input response properties of cochlear nucleus neurons in animals that have developed with tonotopically altered inner ears. Finally, the third aim will investigate the dependence of cochlear nucleus structure on normal topographic innervation from the auditory nerve. These research objectives, if successful, will provide new insights into the mechanisms that establish the functional organization of auditory structures. Revelation of these mechanisms may be informative to optimization strategies for therapeutic interventions in early deafness or hearing loss that aim to preserve normal function and capacity in auditory circuitry.
项目总结:

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

R. Michael Burger其他文献

Development and Function of Inhibitory Circuitry in the Avian Auditory Brainstem
禽听觉脑干抑制电路的发育和功能
  • DOI:
    10.1007/978-3-319-21530-3_5
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    R. Michael Burger
  • 通讯作者:
    R. Michael Burger
Evaluation of UVB reduction by materials commonly used in reptile husbandry.
爬行动物饲养中常用材料减少 UVB 的评估。
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    1.3
  • 作者:
    R. Michael Burger;W. Gehrmann;G. Ferguson
  • 通讯作者:
    G. Ferguson

R. Michael Burger的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('R. Michael Burger', 18)}}的其他基金

Developmental Determination of Central Auditory Physiology by the Inner Ear
内耳中枢听觉生理学的发育决定
  • 批准号:
    10610316
  • 财政年份:
    2022
  • 资助金额:
    $ 36.73万
  • 项目类别:
Efferent inhibitory mechanisms in binaural processing
双耳处理中的传出抑制机制
  • 批准号:
    7769546
  • 财政年份:
    2009
  • 资助金额:
    $ 36.73万
  • 项目类别:
Efferent inhibitory mechanisms in binaural processing
双耳处理中的传出抑制机制
  • 批准号:
    8413054
  • 财政年份:
    2009
  • 资助金额:
    $ 36.73万
  • 项目类别:
Efferent inhibitory mechanisms in binaural processing
双耳处理中的传出抑制机制
  • 批准号:
    7654486
  • 财政年份:
    2009
  • 资助金额:
    $ 36.73万
  • 项目类别:
Efferent inhibitory mechanisms in binaural processing
双耳处理中的传出抑制机制
  • 批准号:
    8020976
  • 财政年份:
    2009
  • 资助金额:
    $ 36.73万
  • 项目类别:
Efferent inhibitory mechanisms in binaural processing
双耳处理中的传出抑制机制
  • 批准号:
    8213448
  • 财政年份:
    2009
  • 资助金额:
    $ 36.73万
  • 项目类别:
THE ROLE OF INHIBITION IN THE AUDITORY BRAINSTEM
抑制在听觉脑干中的作用
  • 批准号:
    6626849
  • 财政年份:
    2001
  • 资助金额:
    $ 36.73万
  • 项目类别:
THE ROLE OF INHIBITION IN THE AUDITORY BRAINSTEM
抑制在听觉脑干中的作用
  • 批准号:
    6294245
  • 财政年份:
    2001
  • 资助金额:
    $ 36.73万
  • 项目类别:
THE ROLE OF INHIBITION IN THE AUDITORY BRAINSTEM
抑制在听觉脑干中的作用
  • 批准号:
    6489519
  • 财政年份:
    2001
  • 资助金额:
    $ 36.73万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了