Developmental Determination of Central Auditory Physiology by the Inner Ear
内耳中枢听觉生理学的发育决定
基本信息
- 批准号:10365728
- 负责人:
- 金额:$ 36.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-01 至 2027-04-30
- 项目状态:未结题
- 来源:
- 关键词:AblationAcoustic NerveAddressAnatomyAnimalsApoptoticArchitectureAuditoryAuditory PhysiologyAuditory systemBasilar PapillaBiophysicsBirdsBrainBrain StemBrain regionCell NucleusCharacteristicsChickCochleaCochlear nucleusCuesDataDependenceDevelopmentEarEarly InterventionElectrophysiology (science)EmbryoEpithelialExhibitsFailureFrequenciesGeneticGoalsHair CellsHealthHearingHearing problemHumanInstructionInterventionInvestigationIon ChannelKnowledgeLabyrinthMammalsMapsMethodsMissionModelingMolecularMorphologyNational Institute on Deafness and Other Communication DisordersNeuraxisNeuronsPathway interactionsPatternPeripheralPhenotypePhysiologyPopulationProcessPropertyResearchRoleSensorySignal TransductionSourceStructureSynapsesSystemTestingTherapeuticTherapeutic InterventionTimeWorkbasebone morphogenic proteinchildhood hearing losschordincochlear developmentcritical perioddeafdeafeningdeafnessexperimental studygenetic manipulationhearing impairmenthearing preservationinnovationinsightjuvenile animalmorphogensnerve supplyneural patterningneurodevelopmentneuron lossotoconiaoverexpressionpreservationrelating to nervous systemresponsesoundtool
项目摘要
Project Summary:
A longstanding and fundamental question of neural development in sensory pathways is: What is the
role of the organization of the sensory epithelium in establishing central topographic organization? In the
auditory system a direct approach to addressing this question has been elusive because it has not been
possible to manipulate the input to the brain from the auditory periphery without either complete ablation of the
inner ear or induction of hearing dysfunction. The proposed experiments will establish for the first time, a model
of repatterned frequency representation in the chick inner ear by utilizing a new genetic manipulation in
embryos. This manipulation takes advantage of the known genetic factors that establish the organization of the
ear at a very early developmental stage that precedes the auditory nerve innervation of the central nervous
system. By overexpressing one of these factors, bone morphogenic protein 7 (BMP7), inner ears develop
almost exclusively low frequency hair cell phenotypes. In the first brain structure to receive auditory nerve
input, the cochlear nucleus, neurons express a number of well characterized biophysical and morphological
specializations for processing sound in specific frequencies. Frequency specific tuning is topographically
mapped in both the ear and auditory brain regions, a feature known as 'tonotopy.' Thus, neural specialization
occurs along an orderly tonotopic map in the cochlear nucleus. The central hypothesis of this proposal is that
tonotopic refinement of specializations in the cochlear nucleus is developmentally determined by patterned
input from the inner ear, and is not independently induced by local cues in the developing brain. This
hypothesis is now testable using animals with tonotopically altered inner ears. The first aim of this proposal is
to examine whether the BMP7 manipulation indeed induces repatterning of hair cell tuning mechanism in the
inner ear. The second aim investigates the electrical input response properties of cochlear nucleus neurons in
animals that have developed with tonotopically altered inner ears. Finally, the third aim will investigate the
dependence of cochlear nucleus structure on normal topographic innervation from the auditory nerve. These
research objectives, if successful, will provide new insights into the mechanisms that establish the functional
organization of auditory structures. Revelation of these mechanisms may be informative to optimization
strategies for therapeutic interventions in early deafness or hearing loss that aim to preserve normal function
and capacity in auditory circuitry.
项目总结:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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R. Michael Burger其他文献
Development and Function of Inhibitory Circuitry in the Avian Auditory Brainstem
禽听觉脑干抑制电路的发育和功能
- DOI:
10.1007/978-3-319-21530-3_5 - 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
R. Michael Burger - 通讯作者:
R. Michael Burger
Evaluation of UVB reduction by materials commonly used in reptile husbandry.
爬行动物饲养中常用材料减少 UVB 的评估。
- DOI:
- 发表时间:
2007 - 期刊:
- 影响因子:1.3
- 作者:
R. Michael Burger;W. Gehrmann;G. Ferguson - 通讯作者:
G. Ferguson
R. Michael Burger的其他文献
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{{ truncateString('R. Michael Burger', 18)}}的其他基金
Developmental Determination of Central Auditory Physiology by the Inner Ear
内耳中枢听觉生理学的发育决定
- 批准号:
10610316 - 财政年份:2022
- 资助金额:
$ 36.73万 - 项目类别:
Efferent inhibitory mechanisms in binaural processing
双耳处理中的传出抑制机制
- 批准号:
7769546 - 财政年份:2009
- 资助金额:
$ 36.73万 - 项目类别:
Efferent inhibitory mechanisms in binaural processing
双耳处理中的传出抑制机制
- 批准号:
8413054 - 财政年份:2009
- 资助金额:
$ 36.73万 - 项目类别:
Efferent inhibitory mechanisms in binaural processing
双耳处理中的传出抑制机制
- 批准号:
7654486 - 财政年份:2009
- 资助金额:
$ 36.73万 - 项目类别:
Efferent inhibitory mechanisms in binaural processing
双耳处理中的传出抑制机制
- 批准号:
8020976 - 财政年份:2009
- 资助金额:
$ 36.73万 - 项目类别:
Efferent inhibitory mechanisms in binaural processing
双耳处理中的传出抑制机制
- 批准号:
8213448 - 财政年份:2009
- 资助金额:
$ 36.73万 - 项目类别: