Study of Cleaners in San Antonio: Immunologic and Inflammatory Responses to Total Volatile Organic Compound (VOC) Exposure

圣安东尼奥清洁工研究：总挥发性有机化合物 (VOC) 暴露的免疫和炎症反应

• 批准号: 10364675
• 负责人: David Gimeno Ruiz de Porras
• 金额: $ 56.39万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-05 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10364675
• 关键词: Address; Air; Air Pollution; Asthma; Biological Markers; Blood; Chemicals; Communities; Country; Data; Development; Educational Activities; Environment; Environmental Hazards; Environmental Health; Exhalation; Exposure to; Future; Goals; Hazardous Chemicals; Health; Hispanic; Hispanic Populations; Home; Home environment; Hour; Housekeeping; Immune; Immune response; Individual; Industrialization; Inequality; Inflammation; Inflammatory Response; Knowledge; Latina; Laws; Link; Lower respiratory tract structure; Measures; Minority; Modeling; Neighborhoods; Not Hispanic or Latino; Occupational; Occupational Exposure; Occupational Health; Outcome; Oxidative Stress; Paint; Pathway interactions; Pattern; Persons; Poison; Pollution; Positioning Attribute; Prevention; Prevention strategy; Reporting; Research; Respiratory Signs and Symptoms; Risk; Sampling; Solvents; Source; South Texas; Texas; Time; United States; Urine; Vulnerable Populations; Wages; Wheezing; Woman; Work; Working Women; airway inflammation; base; community partnership; early detection biomarkers; environmental justice; experience; health disparity; irritation; occupational hazard; outreach; professional atmosphere; recruit; research study; residence; respiratory; respiratory health; self reported behavior; successful intervention; systemic inflammatory response; volatile organic compound; willingness

ABSTRACT Hispanic women working as domestic cleaners are subject to both environmental and occupational hazards because of where they live and work, and this makes this particular group of Hispanics especially vulnerable. To our knowledge, studies have not examined the health impact of exposures to volatile organic compounds (VOC) among Hispanic women who both live in environmental justice neighborhoods and work as domestic cleaners. Despite their large numbers in this country, US labor laws generally exclude domestic cleaners and thus they have limited protections to, among other things: organize, earn minimum wage or overtime pay, have regular breaks, and a healthy and safe work environment. This is particularly true in Texas (TX) which ranks among the states with the highest number of these workers, yet their annual mean wage in TX is among the lowest in the nation. Also, domestic cleaners, particularly in South Texas, are overwhelmingly minorities and are primarily Hispanic or Latina women. Women working as domestic cleaners are subject to a number of environmental and occupational hazards. For example, exposure to hazardous chemicals in cleaning products, such as volatile organic compounds (VOCs), which have been associated with respiratory outcomes (e.g., wheeze, asthma, upper/lower respiratory tract irritation). VOCs are also ubiquitous in the environment and the indoor and neighborhood environments represent important determinants of total personal exposure, even among occupationally exposed person. Thus, in addition to work-related VOC exposure, Hispanic women working as domestic cleaners may experience `double jeopardy', with potentially significant VOC exposures in their home environments. Our long-term goal is to reduce the burden of environmental and occupational hazards and related health outcomes among vulnerable Hispanic women. The objective of this study is to use a community-engaged approach to characterize individual, occupational, and neighborhood-level factors that influence personal air VOC exposure among this overburdened group of Hispanic women in San Antonio, Texas, and to explore associations between these exposures with biomarkers of inflammation and oxidative stress. We will achieve this goal through an ongoing academic-community partnership with a grassroots organization, Domésticas Unidas, an organization that provides outreach and educational activities targeted toward Hispanic, often undocumented, women working in San Antonio, primarily as domestic cleaners. The aims of this study are to (1) Assess personal air VOC exposure and biomarkers of inflammation and oxidative stress among at-risk Hispanic women; (2) Evaluate key, potentially modifiable, determinants of personal air VOC exposure of at-risk Hispanic women at home and work, and; (3) Evaluate the association of personal air VOC exposure with biomarkers of inflammation and oxidative stress among at-risk Hispanic women.

抽象的 担任家庭清洁工的西班牙裔妇女受到环境和职业的双重影响 由于他们生活和工作的地方而存在危险，这使得这一特殊的西班牙裔群体尤其 易受伤害的。据我们所知，研究尚未检验暴露于挥发性有机物对健康的影响 居住在环境正义社区并作为工作人员的西班牙裔妇女中的化合物（VOC） 家庭清洁工。 尽管国内清洁工人数众多，但美国劳动法通常将家庭清洁工排除在外，因此 除其他外，他们在以下方面的保护有限：组织、赚取最低工资或加班费、定期工作 休息以及健康安全的工作环境。在德克萨斯州 (TX) 尤为如此，该州名列前茅。 这些工人数量最多的州，但德克萨斯州的年平均工资却是全美最低的之一 国家。此外，家庭清洁工，特别是在德克萨斯州南部，绝大多数是少数族裔，而且主要是 西班牙裔或拉丁裔女性。 担任家庭清洁工的妇女面临许多环境和职业危害。 例如，接触清洁产品中的危险化学品，如挥发性有机化合物 (VOC)、 与呼吸系统结果相关（例如喘息、哮喘、上/下呼吸道 刺激）。 VOC 在环境中也无处不在，室内和邻里环境代表 个人总接触量的重要决定因素，即使是职业接触者。因此，另外 由于与工作相关的挥发性有机化合物接触，担任家庭清洁工的西班牙裔妇女可能会遇到“双重危险”， 在他们的家庭环境中可能存在大量的挥发性有机化合物暴露。 我们的长期目标是减轻环境和职业危害及相关健康的负担 弱势西班牙裔妇女的结果。本研究的目的是利用社区参与 描述影响个人空气 VOC 的个人、职业和社区因素的方法 德克萨斯州圣安东尼奥市这一负担过重的西班牙裔妇女群体中的暴露情况，并探讨其中的关联 这些暴露与炎症和氧化应激生物标志物之间的关系。我们将通过以下方式实现这一目标 与草根组织 Domésticas Unidas 建立持续的学术界伙伴关系 为西班牙裔（通常是无证工作的女性）提供外展和教育活动 在圣安东尼奥，主要担任家庭清洁工。本研究的目的是 (1) 评估个人空气 VOC 暴露量 高危西班牙裔女性炎症和氧化应激的生物标志物； (2) 评估潜在的关键 高危西班牙裔女性在家庭和工作中个人空气 VOC 暴露的可修改决定因素； (3) 评估个人空气 VOC 暴露与炎症和氧化应激生物标志物的关联 在高危西班牙裔女性中。