Study of Cleaners in San Antonio: Immunologic and Inflammatory Responses to Total Volatile Organic Compound (VOC) Exposure

圣安东尼奥清洁工研究：总挥发性有机化合物 (VOC) 暴露的免疫和炎症反应

• 批准号: 10616809
• 负责人: David Gimeno Ruiz de Porras
• 金额: $ 56.9万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-05 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10616809
• 关键词: Air; Air Pollution; Asthma; Biological Markers; Blood; Chemicals; Classification; Communities; Country; Data; Development; Education and Outreach; Educational Activities; Environment; Environmental Hazards; Environmental Health; Exclusion; Exhalation; Exposure to; Future; Goals; Hazardous Chemicals; Health; Hispanic; Hispanic Populations; Home; Home environment; Hour; Housekeeping; Immune; Immune response; Individual; Industrialization; Inequality; Inflammation; Inflammatory Response; Knowledge; Latina; Laws; Link; Lower respiratory tract structure; Measures; Minority; Modeling; Neighborhoods; Not Hispanic or Latino; Occupational; Occupational Exposure; Occupational Health; Outcome; Oxidative Stress; Paint; Pathway interactions; Pattern; Persons; Physical condensation; Poison; Pollution; Positioning Attribute; Prevention; Prevention strategy; Reporting; Research; Respiratory Signs and Symptoms; Risk; Sampling; Solvents; Source; South Texas; Texas; Time; United States; Urine; Vulnerable Populations; Wages; Wheezing; Woman; Work; Working Women; airway inflammation; community partnership; early detection biomarkers; environmental justice; experience; health disparity; irritation; occupational hazard; professional atmosphere; recruit; research study; residence; respiratory; respiratory health; self reported behavior; successful intervention; systemic inflammatory response; volatile organic compound; willingness

ABSTRACT Hispanic women working as domestic cleaners are subject to both environmental and occupational hazards because of where they live and work, and this makes this particular group of Hispanics especially vulnerable. To our knowledge, studies have not examined the health impact of exposures to volatile organic compounds (VOC) among Hispanic women who both live in environmental justice neighborhoods and work as domestic cleaners. Despite their large numbers in this country, US labor laws generally exclude domestic cleaners and thus they have limited protections to, among other things: organize, earn minimum wage or overtime pay, have regular breaks, and a healthy and safe work environment. This is particularly true in Texas (TX) which ranks among the states with the highest number of these workers, yet their annual mean wage in TX is among the lowest in the nation. Also, domestic cleaners, particularly in South Texas, are overwhelmingly minorities and are primarily Hispanic or Latina women. Women working as domestic cleaners are subject to a number of environmental and occupational hazards. For example, exposure to hazardous chemicals in cleaning products, such as volatile organic compounds (VOCs), which have been associated with respiratory outcomes (e.g., wheeze, asthma, upper/lower respiratory tract irritation). VOCs are also ubiquitous in the environment and the indoor and neighborhood environments represent important determinants of total personal exposure, even among occupationally exposed person. Thus, in addition to work-related VOC exposure, Hispanic women working as domestic cleaners may experience `double jeopardy', with potentially significant VOC exposures in their home environments. Our long-term goal is to reduce the burden of environmental and occupational hazards and related health outcomes among vulnerable Hispanic women. The objective of this study is to use a community-engaged approach to characterize individual, occupational, and neighborhood-level factors that influence personal air VOC exposure among this overburdened group of Hispanic women in San Antonio, Texas, and to explore associations between these exposures with biomarkers of inflammation and oxidative stress. We will achieve this goal through an ongoing academic-community partnership with a grassroots organization, Domésticas Unidas, an organization that provides outreach and educational activities targeted toward Hispanic, often undocumented, women working in San Antonio, primarily as domestic cleaners. The aims of this study are to (1) Assess personal air VOC exposure and biomarkers of inflammation and oxidative stress among at-risk Hispanic women; (2) Evaluate key, potentially modifiable, determinants of personal air VOC exposure of at-risk Hispanic women at home and work, and; (3) Evaluate the association of personal air VOC exposure with biomarkers of inflammation and oxidative stress among at-risk Hispanic women.

摘要 作为家庭清洁工的西班牙裔妇女受到环境和职业的双重影响。 危险，因为他们生活和工作的地方，这使得这个特殊的拉美裔群体，特别是 脆弱据我们所知，研究还没有检查暴露于挥发性有机物对健康的影响， 西班牙裔妇女谁都生活在环境正义社区和工作， 家庭清洁工。 尽管他们在这个国家的大量，美国劳动法通常排除家庭清洁工， 他们在组织、赚取最低工资或加班费、定期休假、 休息，以及健康和安全的工作环境。德克萨斯州（TX）的情况尤其如此， 这些工人人数最多的州，但他们在德克萨斯州的年平均工资是最低的， 民族此外，家庭清洁工，特别是在南德克萨斯州，绝大多数是少数民族，主要是 西班牙裔或拉丁裔女性。 从事家庭清洁工作的妇女受到一些环境和职业危害。 例如，接触清洁产品中的有害化学品，如挥发性有机化合物（VOC）， 其与呼吸结果相关（例如，喘息、哮喘、上/下呼吸道 刺激）。VOC在环境中也是普遍存在的，并且室内和邻近环境代表了 个人接触总量重要决定因素，甚至在职业接触者中也是如此。因此，此外， 与工作有关的挥发性有机化合物接触，西班牙裔妇女作为家庭清洁工可能会遇到“双重危险”， 在他们的家庭环境中有潜在的重大VOC暴露。 我们的长期目标是减少环境和职业危害及相关健康的负担 弱势的西班牙裔女性。本研究的目的是利用社区参与 表征影响个人空气VOC的个人、职业和社区水平因素的方法 在德克萨斯州圣安东尼奥的这群负担过重的西班牙裔妇女中， 与炎症和氧化应激的生物标志物之间的联系。我们将通过以下方式实现这一目标： 与一个基层组织Domésticas Unidas建立了持续的学术-社区伙伴关系， 该组织针对西班牙裔妇女（通常是无证妇女）提供外展和教育活动， 在圣安东尼奥，主要是家庭清洁工。本研究的目的是：（1）评估个人的空气VOC暴露 和炎症和氧化应激的生物标志物在高危西班牙裔妇女;（2）评估关键，潜在的 可修改的，在危险的西班牙裔妇女在家里和工作中的个人空气VOC暴露的决定因素，和;（3） 评估个人空气VOC暴露与炎症和氧化应激生物标志物的相关性 有风险的西班牙裔女性