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Behavioral relevance of active dendritic mechanisms of integration and plasticity

整合和可塑性活跃树突机制的行为相关性

基本信息

批准号：
10364694
负责人：
Daniel A Dombeck
金额：
$ 51.54万
依托单位：
NORTHWESTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-16 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10364694
关键词：
Action Potentials Address Alzheimer&apos s Disease Amnesia Animals Applications Grants Area Back Behavior Behavioral Behavioral Mechanisms Brain Calcium Cells Characteristics Chemosensitization Data Dendrites Disease Environment Epilepsy Event Frequencies Functional Imaging Functional disorder Future Genetic Techniques Glutamates Goals Head Hippocampus (Brain)In Vitro Information Storage Lead Learning Life Location Measurement Mediating Memory Methods Modeling Mus Neurons Neurosciences Research Optics Pattern Play Preparation Prevalence Process Research Resolution Retrieval Role Signal Transduction Slice Source Spatial Behavior Structure Suggestion Synapses Synaptic plasticity Testing Time Trees Work awake base experimental study hippocampal pyramidal neuron information model information processing novel place fields preference presynaptic regenerative spatial memory spatiotemporal virtual environment virtual reality way finding

项目摘要

Project Summary/Abstract The dendritic trees of neurons in the brain's cortex conduct elemental brain functions such as information processing and learning. Research in brain slices has provided a wealth of information about the dendritic mechanisms that could be operating in behaving animals to integrate, and alter the strength of, synaptic inputs from presynaptic sources. Key among these mechanisms are back-propagating action potentials and nonlinear integration of synaptic inputs leading to dendritic spiking, which confer to the dendritic tree a host of local and global plasticity and signaling possibilities. Numerous alluring models of information processing and learning rules have arisen as a result of these in vitro findings, and supported by this R01, we have begun to determine which of these mechanisms are at work in awake, behaving animals. The present proposal leverages recent technical advances used and developed by the PI that enable functional imaging of calcium transients with single dendritic branch resolution and of glutamate input with synaptic scale resolution in the hippocampus of head-restrained mice performing spatial behaviors in a virtual-reality interface. Using these methods, the research proposed in this grant application will allow us to bridge two disconnected areas of neuroscience research: research characterizing the firing patterns and changes in firing patterns of hippocampal neurons during behavior, and research in reduced preparations investigating the mechanisms underlying firing and synaptic plasticity. Specifically, we aim to determine the behavioral relevance and synaptic basis of hippocampal dSpikes. This will allow testing of models of plasticity which have been developed based on in vitro data, across a wide range of parameter space, to finally establish which learning mechanisms are behaviorally relevant.

项目总结/文摘