Behavioral relevance of active dendritic mechanisms of integration and plasticity
整合和可塑性活跃树突机制的行为相关性
基本信息
- 批准号:10364694
- 负责人:
- 金额:$ 51.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-08-16 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:Action PotentialsAddressAlzheimer&aposs DiseaseAmnesiaAnimalsApplications GrantsAreaBackBehaviorBehavioralBehavioral MechanismsBrainCalciumCellsCharacteristicsChemosensitizationDataDendritesDiseaseEnvironmentEpilepsyEventFrequenciesFunctional ImagingFunctional disorderFutureGenetic TechniquesGlutamatesGoalsHeadHippocampus (Brain)In VitroInformation StorageLeadLearningLifeLocationMeasurementMediatingMemoryMethodsModelingMusNeuronsNeurosciences ResearchOpticsPatternPlayPreparationPrevalenceProcessResearchResolutionRetrievalRoleSignal TransductionSliceSourceSpatial BehaviorStructureSuggestionSynapsesSynaptic plasticityTestingTimeTreesWorkawakebaseexperimental studyhippocampal pyramidal neuroninformation modelinformation processingnovelplace fieldspreferencepresynapticregenerativespatial memoryspatiotemporalvirtual environmentvirtual realityway finding
项目摘要
Project Summary/Abstract
The dendritic trees of neurons in the brain's cortex conduct elemental brain functions such as information
processing and learning. Research in brain slices has provided a wealth of information about the dendritic
mechanisms that could be operating in behaving animals to integrate, and alter the strength of, synaptic inputs
from presynaptic sources. Key among these mechanisms are back-propagating action potentials and nonlinear
integration of synaptic inputs leading to dendritic spiking, which confer to the dendritic tree a host of local and
global plasticity and signaling possibilities. Numerous alluring models of information processing and learning
rules have arisen as a result of these in vitro findings, and supported by this R01, we have begun to determine
which of these mechanisms are at work in awake, behaving animals. The present proposal leverages recent
technical advances used and developed by the PI that enable functional imaging of calcium transients with
single dendritic branch resolution and of glutamate input with synaptic scale resolution in the hippocampus of
head-restrained mice performing spatial behaviors in a virtual-reality interface. Using these methods, the
research proposed in this grant application will allow us to bridge two disconnected areas of neuroscience
research: research characterizing the firing patterns and changes in firing patterns of hippocampal neurons
during behavior, and research in reduced preparations investigating the mechanisms underlying firing and
synaptic plasticity. Specifically, we aim to determine the behavioral relevance and synaptic basis of
hippocampal dSpikes. This will allow testing of models of plasticity which have been developed based on in
vitro data, across a wide range of parameter space, to finally establish which learning mechanisms are
behaviorally relevant.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)
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Daniel A Dombeck其他文献
Daniel A Dombeck的其他文献
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{{ truncateString('Daniel A Dombeck', 18)}}的其他基金
Multiplex Imaging of Brain Activity and Plasticity with Optimized FRET/FLIM-based Sensors
使用基于 FRET/FLIM 的优化传感器对大脑活动和可塑性进行多重成像
- 批准号:
10516813 - 财政年份:2023
- 资助金额:
$ 51.54万 - 项目类别:
Behavioral relevance of active dendritic mechanisms of integration and plasticity
整合和可塑性活跃树突机制的行为相关性
- 批准号:
9268796 - 财政年份:2013
- 资助金额:
$ 51.54万 - 项目类别:
Behavioral relevance of active dendritic mechanisms of integration and plasticity
整合和可塑性活跃树突机制的行为相关性
- 批准号:
9893024 - 财政年份:2013
- 资助金额:
$ 51.54万 - 项目类别:
Behavioral relevance of active dendritic mechanisms of integration and plasticity
整合和可塑性活跃树突机制的行为相关性
- 批准号:
8561084 - 财政年份:2013
- 资助金额:
$ 51.54万 - 项目类别:
Behavioral relevance of active dendritic mechanisms of integration and plasticity
整合和可塑性活跃树突机制的行为相关性
- 批准号:
8722038 - 财政年份:2013
- 资助金额:
$ 51.54万 - 项目类别:
Behavioral relevance of active dendritic mechanisms of integration and plasticity
整合和可塑性活跃树突机制的行为相关性
- 批准号:
8891492 - 财政年份:2013
- 资助金额:
$ 51.54万 - 项目类别:
Behavioral relevance of active dendritic mechanisms of integration and plasticity
整合和可塑性活跃树突机制的行为相关性
- 批准号:
10112757 - 财政年份:2013
- 资助金额:
$ 51.54万 - 项目类别:
Behavioral relevance of active dendritic mechanisms of integration and plasticity
整合和可塑性活跃树突机制的行为相关性
- 批准号:
10578695 - 财政年份:2013
- 资助金额:
$ 51.54万 - 项目类别:
Training Program in Neurobiology of Information Storage
信息存储神经生物学培训项目
- 批准号:
10196987 - 财政年份:2003
- 资助金额:
$ 51.54万 - 项目类别:
Training Program in Neurobiology of Information Storage
信息存储神经生物学培训项目
- 批准号:
10628948 - 财政年份:2003
- 资助金额:
$ 51.54万 - 项目类别:
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