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Training Program in Neurobiology of Information Storage

信息存储神经生物学培训项目

基本信息

批准号：
10628948
负责人：
Daniel A Dombeck
金额：
$ 25.86万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10628948
关键词：
Information Storage Neurobiology Training Programs

项目摘要

PROJECT SUMMARY This application seeks to renew the Neurobiology of Information Storage Training Program (NISTP), which is devoted to preparing exceptional predoctoral students for research-intensive careers in the science of learning and memory. Active since 2003, the program is focused on training in fundamental mechanisms of information storage in animals and humans, acting as a central organizer for research in this area at Northwestern. With the recent shift in mental health research toward dimensional, systems-based frameworks, there is unprecedented need for training of the kind offered through this program, which provides training at multiple levels of analyses for understanding mechanisms of learning and memory and their relevance to mental health. The NISTP is based in the Northwestern University Interdepartmental Neuroscience (NUIN) program, emerging from a multidisciplinary group of 31 interactive investigators who have successfully engaged in collaborative research on molecular/genetic, cellular/circuit, and systems/behavioral determinants of information storage. NISTP preceptors have strong track records in predoctoral training and well-funded research programs, and can impart both basic and clinical perspectives to a group of outstanding developing scientists. Training components of the NISTP will include: 1) an advanced course in the latest research in information storage neurobiology, taught by NISTP preceptors; 2) two trainee-hosted lecture series featuring leading investigators in the field of information storage; 3) mock study sections for trainees preparing NRSA applications; and 4) quarterly NISTP meetings including a) “research in progress” trainee talks, b) “bench to bedside” translational discussions, c) “computational modeling and memory” interactive discussions, and d) the annual NISTP retreat. NISTP also serves to educate students in the ethics of science and to recruit students from underrepresented groups to study learning and memory. Continuous evaluation of the program will be accomplished using qualitative mechanisms, such as evaluations by trainees and their mentors, and quantitative measures, such as tracking the research productivity, funding, and career trajectories of former trainees. An internal Steering Committee and an External Advisory Committee will conduct additional assessment processes. Trainees are drawn primarily from a pool of NUIN students who have completed most of the required coursework and have made significant progress in their thesis research. We request continued support for five trainee slots, which will be supplemented with one institutionally funded “affiliate” slot. With the value added by the NISTP, we are confident that NISTP trainees will emerge from their graduate training poised to advance research in fundamental biological mechanisms of learning and memory and well positioned to develop novel translational applications.

项目概要该申请旨在更新信息存储神经生物学培训计划（NISTP），该计划是致力于为学习科学领域的研究密集型职业培养优秀的博士前学生和记忆。该计划自 2003 年开始实施，重点是信息基本机制的培训动物和人类的储存，作为西北大学该领域研究的中心组织者。和最近心理健康研究转向基于维度的、基于系统的框架，对通过该计划提供的培训的需求前所未有，该计划提供多种培训了解学习和记忆机制及其与心理健康的相关性的分析水平。 NISTP 以西北大学跨系神经科学 (NUIN) 项目为基础，由 31 名互动研究人员组成的多学科小组脱颖而出，他们已成功从事分子/遗传、细胞/电路和系统/行为决定因素的合作研究信息存储。 NISTP 导师在博士前培训方面拥有良好的记录并且资金充足研究项目，可以向一批优秀的发展中传授基础和临床观点科学家。 NISTP 的培训内容将包括： 1) 最新研究的高级课程信息存储神经生物学，由 NISTP 导师教授； 2) 两个由实习生主持的系列讲座信息存储领域的领先研究人员； 3) 为学员准备 NRSA 的模拟学习部分应用程序； 4) 每季度举行的 NISTP 会议，包括 a) “正在进行的研究”实习生谈话，b) “替补床边”翻译讨论，c)“计算建模和记忆”互动讨论，以及 d) 年度 NISTP 务虚会。 NISTP 还致力于教育学生科学伦理并招收学生来自代表性不足的群体来研究学习和记忆。该计划的持续评估将使用定性机制完成，例如受训者及其导师的评估，以及定量衡量，例如跟踪前任的研究生产力、资金和职业轨迹实习生。内部指导委员会和外部咨询委员会将开展额外的工作评估流程。受训者主要从完成大部分课程的 NUIN 学生中挑选。完成了所需的课程作业，并在论文研究中取得了重大进展。我们请求继续支持 5 个实习生名额，并辅以 1 个机构资助的“附属”名额。随着 NISTP 的增值，我们相信 NISTP 学员将从研究生培训中脱颖而出准备推进学习和记忆的基本生物机制的研究，并处于有利地位开发新颖的翻译应用程序。

项目成果

期刊论文数量（39）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Overexpression of GAP-43 reveals unexpected properties of hippocampal mossy fibers.

GAP-43 的过度表达揭示了海马苔藓纤维的意外特性。

DOI：
10.1002/hipo.20668
发表时间：
2010
期刊：
Hippocampus
影响因子：
3.5
作者：
Rekart,JeromeL;Routtenberg,Aryeh
通讯作者：
Routtenberg,Aryeh

Physiological properties of cholinergic and non-cholinergic magnocellular neurons in acute slices from adult mouse nucleus basalis.

DOI：
10.1371/journal.pone.0011046
发表时间：
2010-06-10
期刊：
PloS one
影响因子：
3.7
作者：
Hedrick T;Waters J
通讯作者：
Waters J

Behavior determines the hippocampal spatial mapping of a multisensory environment.

DOI：
10.1016/j.celrep.2021.109444
发表时间：
2021-08-03
期刊：
Cell reports
影响因子：
8.8
作者：
Radvansky BA;Oh JY;Climer JR;Dombeck DA
通讯作者：
Dombeck DA

Long-lasting memory from evanescent networks.

来自转瞬即逝的网络的持久记忆。

DOI：
10.1016/j.ejphar.2008.02.047
发表时间：
2008
期刊：
European journal of pharmacology
影响因子：
5
作者：
Routtenberg,Aryeh
通讯作者：
Routtenberg,Aryeh

Estradiol acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism.

DOI：
10.1523/jneurosci.4161-10.2010
发表时间：
2010-12-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Smejkalova T;Woolley CS
通讯作者：
Woolley CS