Training Program in Neurobiology of Information Storage

信息存储神经生物学培训项目

• 批准号: 10628948
• 负责人: Daniel A Dombeck
• 金额: $ 25.86万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628948
• 关键词: Information Storage; Neurobiology; Training Programs

PROJECT SUMMARY This application seeks to renew the Neurobiology of Information Storage Training Program (NISTP), which is devoted to preparing exceptional predoctoral students for research-intensive careers in the science of learning and memory. Active since 2003, the program is focused on training in fundamental mechanisms of information storage in animals and humans, acting as a central organizer for research in this area at Northwestern. With the recent shift in mental health research toward dimensional, systems-based frameworks, there is unprecedented need for training of the kind offered through this program, which provides training at multiple levels of analyses for understanding mechanisms of learning and memory and their relevance to mental health. The NISTP is based in the Northwestern University Interdepartmental Neuroscience (NUIN) program, emerging from a multidisciplinary group of 31 interactive investigators who have successfully engaged in collaborative research on molecular/genetic, cellular/circuit, and systems/behavioral determinants of information storage. NISTP preceptors have strong track records in predoctoral training and well-funded research programs, and can impart both basic and clinical perspectives to a group of outstanding developing scientists. Training components of the NISTP will include: 1) an advanced course in the latest research in information storage neurobiology, taught by NISTP preceptors; 2) two trainee-hosted lecture series featuring leading investigators in the field of information storage; 3) mock study sections for trainees preparing NRSA applications; and 4) quarterly NISTP meetings including a) “research in progress” trainee talks, b) “bench to bedside” translational discussions, c) “computational modeling and memory” interactive discussions, and d) the annual NISTP retreat. NISTP also serves to educate students in the ethics of science and to recruit students from underrepresented groups to study learning and memory. Continuous evaluation of the program will be accomplished using qualitative mechanisms, such as evaluations by trainees and their mentors, and quantitative measures, such as tracking the research productivity, funding, and career trajectories of former trainees. An internal Steering Committee and an External Advisory Committee will conduct additional assessment processes. Trainees are drawn primarily from a pool of NUIN students who have completed most of the required coursework and have made significant progress in their thesis research. We request continued support for five trainee slots, which will be supplemented with one institutionally funded “affiliate” slot. With the value added by the NISTP, we are confident that NISTP trainees will emerge from their graduate training poised to advance research in fundamental biological mechanisms of learning and memory and well positioned to develop novel translational applications.

项目摘要 本应用程序旨在续签信息存储培训计划（NISTP）的神经生物学，这是 致力于为学习科学的研究密集型职业准备卓越的前学生 和内存。自2003年以来活跃，该计划专注于培训信息的基本机制 在动物和人类中存储，是西北地区该地区研究的中心组织者。和 心理健康研究最近向基于系统的框架的转变，有 该计划提供的培训的前所未有的培训需要，该计划提供了多次培训 理解学习和记忆机制及其与心理健康相关的分析水平。 NISTP总部位于西北大学跨部门神经科学（NUIN）计划， 来自31个互动研究人员的多学科小组的出现，他们成功地参与了 关于分子/遗传，细胞/电路以及系统/行为决定者的协作研究 信息存储。 NISTP受体在训练前具有强大的往绩记录，并资助良好 研究计划，可以将基本和临床观点授予一群杰出的发展 科学家。 NISTP的培训组件将包括：1）最新研究的高级课程 NISTP教育者教授的信息存储神经生物学； 2）两个学员主持的演讲系列 信息存储领域的主要研究人员； 3）学员准备的模拟研究部分NRSA 申请； 4）季度NISTP会议，包括a）“正在进行的研究”学员会谈，b） 床边”翻译讨论，c）“计算建模和记忆”互动讨论，d） 年度NISTP务虚会。 NISTP还可以教育学生就科学伦理学并招募学生 从代表性不足的群体到学习学习和记忆。该程序的持续评估将是 使用定性机制（例如培训及其导师评估）和 定量措施，例如跟踪形式的研究生产力，资金和职业轨迹 学员。内部指导委员会和外部咨询委员会将进行更多 评估过程。受训者是从完成最多的NUIN学生池中吸引的 在所需的课程中，他们的论文研究取得了重大进展。我们要求继续 支持五个学员老虎机，这些老虎机将补充一个机构资助的“会员”插槽。与 由NISTP添加的增值，我们相信NISTP学员将从他们的研究生培训中出现 被毒化以提高学习和记忆的基本生物学机制的研究，并且位置良好 开发新颖的翻译应用。

项目成果

Overexpression of GAP-43 reveals unexpected properties of hippocampal mossy fibers.

GAP-43 的过度表达揭示了海马苔藓纤维的意外特性。

• DOI: 10.1002/hipo.20668
• 发表时间: 2010
• 期刊: Hippocampus
• 影响因子: 3.5
• 作者: Rekart,JeromeL;Routtenberg,Aryeh
• 通讯作者: Routtenberg,Aryeh

Physiological properties of cholinergic and non-cholinergic magnocellular neurons in acute slices from adult mouse nucleus basalis.

• DOI: 10.1371/journal.pone.0011046
• 发表时间: 2010-06-10
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Hedrick T;Waters J
• 通讯作者: Waters J

Behavior determines the hippocampal spatial mapping of a multisensory environment.

• DOI: 10.1016/j.celrep.2021.109444
• 发表时间: 2021-08-03
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Radvansky BA;Oh JY;Climer JR;Dombeck DA
• 通讯作者: Dombeck DA

Long-lasting memory from evanescent networks.

来自转瞬即逝的网络的持久记忆。

• DOI: 10.1016/j.ejphar.2008.02.047
• 发表时间: 2008
• 期刊: European journal of pharmacology
• 影响因子: 5
• 作者: Routtenberg,Aryeh

Estradiol acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism.

• DOI: 10.1523/jneurosci.4161-10.2010
• 发表时间: 2010-12-01
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Smejkalova T;Woolley CS
• 通讯作者: Woolley CS