Optimization of MeV FLASH radiotherapy for normal tissue preservation
MeV FLASH 放射治疗对正常组织保存的优化
基本信息
- 批准号:10366743
- 负责人:
- 金额:$ 64.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-06 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdoptionAnimalsAreaBasic ScienceBedsBiochemistryBiological AssayBiologyBiomedical EngineeringBrainBreast LymphomaCanis familiarisChemistryClinicalColonConsumptionDNA DamageDataDevicesDoctor of PhilosophyDoseDose-RateEffectivenessElectron Spin Resonance SpectroscopyEngineeringEnsureFree RadicalsFutureGeneticHead and neck structureHumanHypoxiaImageIn SituIn VitroInternationalIowaIronLinkLungMalignant NeoplasmsMeasurementMeasuresMethodsMolecularMorphologyNormal tissue morphologyNorris Cotton Cancer CenterOpticsOxygenOxygen saturation measurementPathologyPathway interactionsPatientsPerformancePhysicsPhysiologic pulseProductionProteomicsPublicationsRadiationRadiation Dose UnitRadiation GeneticsRadiation OncologyRadiation PhysicsRadiation induced damageRadiation therapyRadiobiologyRadiochemistryReactionReactive Oxygen SpeciesResearchResearch Project GrantsRiskRunningSchoolsSkinSystemTechniquesTherapeuticTherapeutic EffectTissue PreservationTissuesTranslationsTumor TissueUnited States National Institutes of HealthValidationWorkbasecell killingdesigndosimetryfirst-in-humangastrointestinalin vivoinstrumentationinternal radiationirradiationluminescencemouse modelopen sourceoxidationpre-clinicalpreservationprogramsprototyperadiation effectrepairedtissue oxygenationtooltreatment comparisontreatment planningtumor
项目摘要
ABSTRACT
Significant improvement in the effectiveness of radiation therapy (RT) now seems possible because of recent
exciting research results using ultra-high dose rates (UHDR), indicating that normal tissue damage can be
reduced (the `FLASH' effect), compared to conventional radiation for the same total dose. FLASH RT delivery
has shown reduced morphological and functional damage to normal tissues such as brain, colon, lung, and skin.
Although significant research remains, early indications are that the normal tissue sparing effect may as high
50% at some dose levels. If proven in translation, this effect would be the most significant improvement in RT
therapeutic ratio since the advent of treatment planning. While intriguing mechanisms for this result have been
postulated, they remain only well-reasoned speculations because of a lack of direct in vivo data on the physico-
chemical mechanisms including oxygen depletion and free radical species alterations. Dartmouth has created
the first reversible MeV FLASH beam on a clinically commissioned linac with >100 Gy/s at the patient treatment
bed, and prototyped an open-source treatment planning system, expanding research access. Additionally, the
team has invented unique technological capabilities to directly measure the highest dose rates and in vivo tissue
oxygen transients. The key technological barriers solved in the proposed research with preliminary data are: 1)
demonstration of conversion to a UHDR irradiator within a clinically commissioned linac, 2) verification of per-
pulse and per-fraction dose rates, 3) direct in vivo observation of oxygen transients, 4) direct measurements of
free radical species changes in vitro, and 5) access to functional tissue assays and genetic and proteomic
assays. Single-pulse and single-fraction dose rates will be quantified by high frame rate imaging. Additionally,
the in vivo oxygen changes will be quantified by two independent methods for co-validation, including electron
paramagnetic resonance oximetry and optical luminescence oximetry. Free radical species changes produced
from transient hypoxia will also be assessed through systematic in vitro analyses, and the potential linkages to
functional, proteomic and DNA damage examined. The FLASH beam conditions that minimize normal tissue
damage for a fixed dose will be established with this baseline data. The work is pre-clinical but can be readily
adapted to ongoing NIH sponsored spontaneous canine cancer studies has relevance to future large animal and
first-in-human translation. Multiple Dartmouth centers partnered to initiate and support this FLASH program.
Taken altogether, this bioengineering research project will advance the state of the art in high dose rate radiation
therapy using tools that have been uniquely developed by our 3 research groups, and the project results will
build the basic science needed to support proposed human translation of this ground-breaking field. The team
has leading expertise in radiation physics, in vivo molecular measurement, and radiation genetics and
immunomolecular biology and pathology. The work is supported by an External Advisory Board of international
expert FLASH consultants, as well as an internal Radiation Oncology Advisory Group.
摘要
放射治疗(RT)有效性的显著改善现在似乎是可能的,因为最近的
使用超高剂量率(UHDR)的令人兴奋的研究结果表明,正常组织损伤可以
与相同总剂量的常规辐射相比,减少了(‘闪光’效应)。Flash RT交付
对脑、结肠、肺和皮肤等正常组织的形态和功能损害有所减少。
尽管仍有重要的研究,但早期迹象表明,正常组织的节约率可能高达
在某些剂量水平下为50%。如果在翻译中得到证实,这一效果将是RT最显著的改进
自治疗计划问世以来的治疗比率。虽然这一结果的耐人寻味的机制
据推测,它们仍然只是有理有据的推测,因为缺乏直接的体内物理数据--
化学机制包括氧气耗竭和自由基物种改变。达特茅斯已经创造了
临床委托的直线加速器上的第一个可逆MeV闪光束流>;100GY/S治疗患者
Bed,并建立了一个开源治疗规划系统的原型,扩大了研究渠道。此外,
该团队发明了独特的技术能力,可以直接测量最高剂量率和体内组织
氧气瞬变。利用初步数据提出的研究中解决的关键技术障碍是:1)
在临床委托的直线加速器内转换为UHDR辐照器的演示,2)验证PER。
脉冲和每分数剂量率,3)氧瞬变的直接活体观察,4)直接测量
自由基物种在体外的变化,以及5)获得功能组织分析以及遗传和蛋白质组学
化验。单脉冲和单分数剂量率将通过高帧速率成像进行量化。另外,
体内的氧气变化将通过两种独立的方法进行量化,以进行共同验证,包括电子
顺磁共振血氧仪和光致发光血氧仪。产生的自由基物种变化
也将通过系统的体外分析来评估暂时性低氧引起的,以及与
检查功能、蛋白质组和DNA损伤。使正常组织最小化的闪光条件
固定剂量的损害将根据这一基线数据确定。这项工作是临床前的,但可以很容易地
适应正在进行的NIH赞助的自发性犬癌研究,与未来的大型动物和
人类第一个翻译。多个达特茅斯中心合作发起并支持这一闪光计划。
综上所述,这一生物工程研究项目将推动高剂量率辐射技术的发展。
使用由我们的3个研究小组独家开发的工具进行治疗,项目结果将
建立所需的基础科学,以支持这一开创性领域的拟议人工翻译。该队
在辐射物理、体内分子测量和辐射遗传学方面拥有领先的专业知识
免疫分子生物学和病理学。这项工作得到了国际社会的外部咨询委员会的支持
专家闪光灯顾问,以及内部放射肿瘤学咨询小组。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David J. Gladstone其他文献
Oxygen Consumption In Vivo by Ultra-High Dose Rate Electron Irradiation Depends Upon Baseline Tissue Oxygenation
超高剂量率电子辐照在体内的耗氧量取决于基线组织氧合作用
- DOI:
10.1016/j.ijrobp.2024.10.018 - 发表时间:
2025-03-15 - 期刊:
- 影响因子:6.500
- 作者:
Jacob P. Sunnerberg;Armin D. Tavakkoli;Arthur F. Petusseau;Noah J. Daniel;Austin M. Sloop;Wilson A. Schreiber;Jiang Gui;Rongxiao Zhang;Harold M. Swartz;P. Jack Hoopes;David J. Gladstone;Sergei A. Vinogradov;Brian W. Pogue - 通讯作者:
Brian W. Pogue
Fast Deformable Image Registration for Real-Time Target Tracking During Radiation Therapy Using Cine MRI and Deep Learning
- DOI:
10.1016/j.ijrobp.2022.09.086 - 发表时间:
2023-03-15 - 期刊:
- 影响因子:
- 作者:
Brady Hunt;Gobind S. Gill;Daniel A. Alexander;Samuel S. Streeter;David J. Gladstone;Gregory A. Russo;Bassem I. Zaki;Brian W. Pogue;Rongxiao Zhang - 通讯作者:
Rongxiao Zhang
Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy: The ARCADIA Randomized Clinical Trial.
阿哌沙班预防心房性心脏病患者隐源性中风复发:ARCADIA 随机临床试验。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Hooman Kamel;W. Longstreth;D. Tirschwell;R. Kronmal;R. Marshall;Joseph Broderick;R. Aragón García;P. Plummer;Noor Sabagha;Qi Pauls;C. Cassarly;Catherine R Dillon;Marco R. Di Tullio;E. Hod;E. Soliman;David J. Gladstone;Jeffrey S Healey;Mukul Sharma;Seemant Chaturvedi;L. S. Janis;Balaji Krishnaiah;Fadi Nahab;Scott E. Kasner;Robert J. Stanton;Dawn O. Kleindorfer;Matthew Starr;Toni R. Winder;Wayne M. Clark;Benjamin Miller;Mitchell S. V. Elkind;Ganesh Asaithambi;Maxwell Klaiman;Konark Malhotra;Mary Fetter;Anna Wanahita;Stacie Merritt;Rehan Sajjad;Kate McPolin;Bruce Coull;Shriya Kavathia;Murali Kolikonda;Sara Calhoun;Felipe De Los Rios La Rosa;Ian Del Conde;Josette Elysée;A. Aghaebrahim;Melissa Stratoberdha;Andria Ford;James Giles;Yan Wang;Jennifer Babka;Rahul Damani;Barbara Gutierrez;Sandeep Kumar;Sarah Marchina;Marc Swerdloff;Margaret Scott;Amandeep Sangha;Kelly Patterson;Julie Shulman;Steven Feske;José Rafael Romero;Hugo Aparicio;David M. Greer;Rebecca Stafford;Arturo Tamayo;Leanne Anderson;S. Smirnakis;Quinn Rademaker;Maurice Hourihane;Robert N. Sawyer;Marilou I Ching;Amit Kandel;Rakesh Magun;Annemarie Crumlish;Annaliese Bosco;Sanjay Singh;Abhishek Singh;Elizabeth Traynor;Rammohan Sankaraneni;Toufik Haddad.;Carly Isder;Lois Rasmussen;Dustin Rochestie;Nancy Brunetti;Dhruvil Pandya;Rosemarie Baligod;Dan Capampangan;Allegra Sahelian;Jason Nomura;Kimberly Gannon;Jonathan Raser;Kathleen Murphy;Ahmed Itrat;Debra Hudock;D. Wisco;Laura Sweeney;William Likosky;Rebekah Garcia;Hermann Schumacher;Lindsey Colman;Benjamin Lisle;Uriah Atkinson;Wady Aude;Cassandra Trevino;Kevin Attenhoffer;Claudia Fortiche;Kumar Rajamani;Amanda Reyes;Hasnain Arshad;Julie Weidman;Peter Adamczyk;Leah Galvez;Fadi Nahab;Michael Frankel;Alicia Escobar;Kiva Schindler;Megan Schultz;Lori Bhadsavle;Leah Craft;Ariane Mackey;S. Verreault;Marie;S. Gosselin;Suzy Lavoie;Nirav Patel;Richard Bailey;Marc Lazzaro;Marek Čierny;Ann Helms;Caitlin Moore;Diane Book;Hatim Attar;Tiffany Morse;Sophia Aboagye;Lakiesha Coleman;Katie Alter;Rodney Short;Desyree Weakley;Jana Wold;Kinga Aitken;Harmeet Sachdev;Audrey Paulson;Nicolas Bianchi;Kelvin Ng;K. Ratnayake;D. Tirschwell;Mary Asirot;Allison Kunze;Yan Hou;Reena Patel;Laura Greiner;Benjamin Miller;J. Scherber;A. Katramados;Teresa Wiegand;Scott E. Kasner;Rebecca Burdett;Brett Cucchiara;Steven Messe;Qingyang Yuan;Donna Kurowski George;J. Witsch;Laura Stein;Christopher Favilla;James Siegler;Jesse Thon;Michael Mullen;Aaron Rothstein;Ossama Khaazal;Daniel Cristancho;Emily Grodinsky;Farhan Khan;Christopher Renner;Jonah Zuflacht;Kelley A. Humbert;Aroosh Kumar;Judy Dawod;Gbambele Kone;Sahily Reyes;Nino Kvantaliani;Mary Liz De Santo;Nichole Gallatti;Devin Keating;Mauricio Concha;Robynn Pannell;N. Murray;Jacki Anderson;Lindsay Bosh;Erika Marulanda;Andrea Escobar;Z. 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Hsia;Chandni Kalaria;Shannon P. Burton;Yongwoo Kim;Sana Somani;Veronica Craft;Jamal Smith;Juby Matthews;Megan Grainger;Cassidy Anderson;Christine Holmstedt;Caitlan Lematty;A. Sharrief;Gabretta Cooksey;Yazan Alderazi;Chad Tremont;L. Maidan;Danielle Hornbuckle;Osama O. Zaidat;Cynthia Upham;Balaji Krishnaiah;Andrei Alexandrov;C. Elangovan;Mark Rubin;Quentin Thacker;Joseph Hanna;Dana Cook;Bradley Jacobs;Christina Weller;Kathryn Kirchoff;Mellanie Springer;Khadean Moncrieffe;Tanzina Islam;Pramod Sethi;Jamil Ahmed;Steven Rudolph;Holly Morhaim;C. Brockington;Naresh Poondla;Calvin Hansen;Heather Banker;Imama Naqvi;Eliza Miller;Carmen Castillo;R. Aragón García;Kevin Slane;Neal Parikh;Babak Navi;Saad Mir;Alan Segal;Halina White;Ava Liberman;Dana Leifer;Hooman Kamel;Carla Sherman;Jed H. Kaiser;Vanessa Liao;Natalie M LeMoss;Kelsey Lansdale;Aaron Lord;Maria Cotrina;Jose Torres;Danika Anganoo;Toni R. Winder;J. Elliot;Yahya Atalay;Courtney Stathis;Jeffrey Katz;Erin Schwartz;Kayla Stanton;Sandra Anghel;Ahmad Ballout;Alicia Dee;Morteza Modaber;Neisha Patel;Rohan Arora;Ina Teron;Richard Libman;Kirendra Pasram;Fan Caprio;Rachel Vincent;Arun Talkad;Ashwath Ravisankar;Alicia Zha;Mohammad Hamed;Evgeny Sidorov;Danny Samkutty;David Gordon;Robert Hamilton;Faddi Velez;Jason King;Bappaditya Ray;April Vaughn;Blair Hill;Jason Sharps;Richard Zweifler;Jessica Henry;Wayne M. Clark;H. Bozorgchami;Parker Miller;Rachel Laursen;Sonesh Amin;Megan Pattle;Jon Foley;Monica Dolan;Emilie Nagle;Paulo Zortea;Reilly Leonard;Souvik Sen;Nishanth Kodumuri;Justin Lowe;M. Logue;Amanda Kabetso;Phil Fleming;Corey White;Damon Gates;A. Towfighi;M. Ayala;Raul Guisado;Karen De La Cuest;Maria Pyle;Tina M Burton;Karen L Furie;S. Yaghi;Narendra S Kala;Ashley Schomer;Scott Moody;Deepica Chaudhry;Catrina Elizardo;Nirav Vora;Katy Groezinger;Deviyani Mehta;Michelle Moccio;Edward Stenroos;J. Saver;Daisy Mercado;Brett Graham;Gary Hunter;L. Peeling;Michael Kelly;R. Cooley;S. Wasyliw;C. Tyson;E. Junk;K. Foster;K. Bolt;L. Urroz;R. Whelan;A. Gardner;Shrijal Bhavsar;Laurel Cherian;James Conners;Sarah Song;Rima M. Dafer;Alejandro Vargas;Henna McCoy;Karin Olds;Debbie Summers;Rene Colorado;Terri Nielsen;Juan Morales;Claude Hemphill;Dominica Randazzo;Destini Spaeth;Jason Neal;Melissa Zdroik;R. Modir;Theresa Mcquaid;Yu Cheng;C. Murphy;Henrik Manassarians;Fazeel Siddiqui;Laura Reiser;Muhib Khan;Heidi Taylor;Stephanie Mueller;Naim Khoury;Lauren Bainter;Supreet Kaur;Guadalupe Calzadillas;R. Edgell;Benjamin Cummins;Logan McDaneld;Lisa Bertrand;Kelly Matmati;Nabil Matmati;Nirali Vora;Madelleine Garcia;David Spence;Tisha Mabb;Curtis Benesch;Emily Prentiss;J. Hopyan;David J. Gladstone;I. Fatakdawala;Manoj K. Mittal;Tammy Donnel;Dawn Lenakakis;Katharyn Gelinas;Alicia Bennett;W. Burgin;Marla Hairston;Paul Katz;Hannah Reimer;Rony Salem;Tracy Stern;Robin Dharia;Sasha Paglione;Christopher Goshgarian;Stacy Smith;Emiliya Melkumova;Nikolas Melkumyan;S. Onteddu;Lisa Richardson;M. Shafie;Wengui Yu;Julia Fong;Josue Prado;Karen Rapp;Wade Smith;Christina Wilson;Neringa May;S. Sundararajan;Mary Andrews;R. Goddeau;Brian Silver;Christina Manxhari;Meaghan Demers;Cynthia Kenmuir;Kristen Kerfoot;Christy Ireland;Matthew Starr;Ty Shang;Mark Johnson;Erica Jones;Mehari Gebreyohannas;Jessica Clark;Andrew Southerlandc;Bradford Worrallc;Matthew Gusler;Keri JohnsonN;Necrisha Roach;Sherita Chapman;Nina Solenski;Rohini Bhole;Amna Sohail;Karen Johnston;Andrew Weko;Miah Perch;Cheyenne Batton;Allison Ramsey;Sonya Gunter;Jane E Monita;Marie Meyer;Jennifer Murwin;Kaitlin A. Lundell;Nimco Essa;Michael Lyerly;Tammy Davis;Ashfaq Shuaib;L. Piquette;Michael Hill;S. Coutts;Supriya Save;Karla J. Ryckborst;C. Kenney;Lana Toussaint;J. Brorson;E. Coleman;Emma Hall;Robert J. Stanton;Dawn O. Kleindorfer;S. Demel;Jennifer Powers;F. Testai;Maureen Hillmann;Enrique C Leira;Heena M. Olalde;Jorge Kawano;Aparna Pendurthi;Margaret Houghton;Justin Moore;Joel Maruthanal;Alissa Fugate;Saurav Das;Creed L. Pettigrew;Pattricia Arnold;Tracy Ander;Ann Jerde;Seemant Chaturvedi;Christina Spadafora;Joseph Carrera;Christopher Becker;Devin Brown;James Burke;Frank Conyers;Anthony Harrington;Christopher Hill;Jessica Roberts;Patty Johnson;Shashank Shekhar;S. Gangadhara;Margaret Smith;Pierre Fayad;Helen Obaro;Tarun Girotra;Jacqueline Morales;Erin Rael;Muhammad;Rebecca Sugg;Tamekia Grissett;Stefanie White;Reza Behrouz;Jody Richardson;Lee Chung;J. Majersik;Dana DeWitt;Stephanie Lyden;Vivek Reddy;Peter Tekiela;Peter Hannon;Adam de Havenon;Brian Marcus;Knut Hoversten;Chelsea Meyer;Jerdan Ruff;Theodore Rock;Michael Dela Cruz;Edward Bradbury;Jenna Bock;Kevin Call;Ryan McQuivey;Karen Belanger;Andrew A. Huffer;Sharon McRae;Ameer E Hassan;Raza Khan;Olive Sanchez;Thalia S Field;Laura Wilson;J. Gorman;Stephen Van Gaal;S. Yip;P. Teal;Oscar R. Benavente;S. Mann;P. King;G. Maclean;Carson Ma;K. Villaluna;Michael T. Froehler;Hemangi Rajpal;Muhammad Alvi;Sara Dobrzynski;Jay Sherman;Cheryl Bushnell;Krystal Schmidt;Roi Wallis;Kimberly Panizzon;Reshma Narula;L. Kuohn;Sara Jasak;Michael C Kampp;Melissa Pish - 通讯作者:
Melissa Pish
The value of MRI in transient ischemic attack/minor stroke following a negative CT for predicting subsequent stroke
- DOI:
10.1007/s43678-024-00853-7 - 发表时间:
2025-02-04 - 期刊:
- 影响因子:2.000
- 作者:
Matthieu Robitaille;Marcel Émond;Mukul Sharma;Ariane Mackey;Pierre-Gilles Blanchard;Marie-Joe Nemnom;Marco L. A. Sivilotti;Ian G. Stiell;Grant Stotts;Jacques Lee;Andrew Worster;Judy Morris;Ka Wai Cheung;Albert Y. Jin;Demetrios J. Sahlas;Heather E. Murray;Steve Verreault;Marie-Christine Camden;Samuel Yip;Philip Teal;David J. Gladstone;Mark I. Boulos;Nicolas Chagnon;Elizabeth Shouldice;Clare Atzema;Tarik Slaoui;Jeanne Teitlebaum;George A. Wells;Jeffrey J. Perry - 通讯作者:
Jeffrey J. Perry
A Multicentre Prospective Cohort Study to Identify High-Risk Transient Ischemic Attack/Minor Stroke Patients Benefitting from Echocardiography
一项多中心前瞻性队列研究:识别能从超声心动图检查中获益的高危短暂性脑缺血发作/轻型卒中患者
- DOI:
10.1016/j.cjca.2024.09.008 - 发表时间:
2024-12-01 - 期刊:
- 影响因子:5.300
- 作者:
Jeffrey J. Perry;Abdulaziz Alsadoon;Marie-Joe Nemnom;Marco L.A. Sivilotti;Marcel Émond;Ian G. Stiell;Grant Stotts;Jacques S. Lee;Andrew Worster;Judy Morris;Ka Wai Cheung;Albert Y. Jin;Demetrios J. Sahlas;Heather E. Murray;Ariane Mackey;Steve Verreault;Marie-Christine Camden;Samuel Yip;Philip Teal;David J. Gladstone;Mukul Sharma - 通讯作者:
Mukul Sharma
David J. Gladstone的其他文献
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{{ truncateString('David J. Gladstone', 18)}}的其他基金
Optimization of MeV FLASH radiotherapy for normal tissue preservation
MeV FLASH 放射治疗对正常组织保存的优化
- 批准号:
10604253 - 财政年份:2022
- 资助金额:
$ 64.22万 - 项目类别:
OPTICAL CHERENKOV IMAGING DOSIMETRY IN HUMAN RADIOTHERAPY
人体放射治疗中的光学契伦科夫成像剂量测定
- 批准号:
10544455 - 财政年份:2022
- 资助金额:
$ 64.22万 - 项目类别:
OPTICAL CHERENKOV IMAGING DOSIMETRY IN HUMAN RADIOTHERAPY
人体放射治疗中的光学契伦科夫成像剂量测定
- 批准号:
10560892 - 财政年份:2022
- 资助金额:
$ 64.22万 - 项目类别:
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- 资助金额:
$ 64.22万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 64.22万 - 项目类别:
EU-Funded
Assessing the Coordination of Electric Vehicle Adoption on Urban Energy Transition: A Geospatial Machine Learning Framework
评估电动汽车采用对城市能源转型的协调:地理空间机器学习框架
- 批准号:
24K20973 - 财政年份:2024
- 资助金额:
$ 64.22万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 64.22万 - 项目类别:
EU-Funded
De-Adoption Beta-Blockers in patients with stable ischemic heart disease without REduced LV ejection fraction, ongoing Ischemia, or Arrhythmias: a randomized Trial with blinded Endpoints (ABbreviate)
在没有左心室射血分数降低、持续性缺血或心律失常的稳定型缺血性心脏病患者中停用β受体阻滞剂:一项盲法终点随机试验(ABbreviate)
- 批准号:
481560 - 财政年份:2023
- 资助金额:
$ 64.22万 - 项目类别:
Operating Grants
Our focus for this project is accelerating the development and adoption of resource efficient solutions like fashion rental through technological advancement, addressing longer in use and reuse
我们该项目的重点是通过技术进步加快时装租赁等资源高效解决方案的开发和采用,解决更长的使用和重复使用问题
- 批准号:
10075502 - 财政年份:2023
- 资助金额:
$ 64.22万 - 项目类别:
Grant for R&D
Engage2innovate – Enhancing security solution design, adoption and impact through effective engagement and social innovation (E2i)
Engage2innovate — 通过有效参与和社会创新增强安全解决方案的设计、采用和影响 (E2i)
- 批准号:
10089082 - 财政年份:2023
- 资助金额:
$ 64.22万 - 项目类别:
EU-Funded
Collaborative Research: SCIPE: CyberInfrastructure Professionals InnoVating and brOadening the adoption of advanced Technologies (CI PIVOT)
合作研究:SCIPE:网络基础设施专业人员创新和扩大先进技术的采用 (CI PIVOT)
- 批准号:
2321091 - 财政年份:2023
- 资助金额:
$ 64.22万 - 项目类别:
Standard Grant