OPTICAL CHERENKOV IMAGING DOSIMETRY IN HUMAN RADIOTHERAPY

人体放射治疗中的光学契伦科夫成像剂量测定

• 批准号: 10544455
• 负责人: David J. Gladstone
• 金额: $ 61.14万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10544455
• 关键词: 3-Dimensional; Accreditation; Advanced Development; Archives; Area; Breast; Calibration; Chronic; Clinical; Clinical Management; Complex; Core Grant; Data; Deposition; Development; Doctor of Philosophy; Dose; Dose-Rate; Electrons; Embryo; Engineering; Fatty acid glycerol esters; Funding; Geometry; Grant; Human; Image; Image Analysis; Imaging Device; Imaging technology; Institution; Leadership; Legal patent; Light; Linear Accelerator Radiotherapy Systems; Maps; Medical; Medicine; Methodology; Methods; Noise; Norris Cotton Cancer Center; Optics; Patient imaging; Patients; Physics; Physiologic pulse; Positioning Attribute; Property; Protons; Publications; Radiation; Radiation Dose Unit; Radiation Oncology; Radiation therapy; Recording of previous events; Research; Research Project Grants; Resources; Role; Scanning; Schools; Science; Shapes; Signal Transduction; Skin; Somatotype; Surface; System; Techniques; Technology; Testing; Therapeutic; Time; TimeLine; Tissues; Visual; Visualization; Work; animation; base; cherenkov imaging; clinically relevant; commercialization; design; dosimetry; experience; human imaging; human tissue; imaging facilities; imaging system; improved; innovation; oncology program; optical imaging; programs; quantitative imaging; real-time images; skin color; success; technology development; tool; treatment center; treatment optimization; treatment planning

ABSTRACT Optical imaging of Cherenkov emission from tissue during radiotherapy has been demonstrated in humans, providing a map correlated to radiation dose within the surface tissues. In external beam radiotherapy, the signal is optimally captured by time-gated intensified cameras, synchronized to the linear accelerator pulses, allowing rejection of the majority of background room light, and providing real time video of each radiotherapy treatment with standard dose rates. This discovery combined with CT and reflectance calibration has the potential to allow accurate quantitative dose imaging in humans for the first time in the history of therapeutic radiation use. While the imaging technology has inherent limitations to surface regions, the fact that it is a real time imaging tool and provide visual recording of every feature of a treatment plan is revolutionary. It has the potential for a paradigm change in how radiotherapy is documented and archived for daily reliance, quality audit and potentially automated control of delivery. The implementation of Cherenkov imaging is significantly simpler than most dosimetry tools, however the understanding and interpretation of the images need to be established, in order to be clear about what is possible in imaging delivery of dose. This proposed technology developments advance the methods for quantitative dose imaging in whole breast radiation treatment using our patented approach to CT/reflectance calibration of Cherenkov imaging, will be advanced and tested in regular treatments. Additionally, we will advance the ability to image patients with complex multi-field treatments, where adjacent beam fields are matched, so that we can quantify the dose accuracy at the match lines. Another application is treatment of total skin with electron therapy, where the field is extremely large and so imaging dosimetry makes sense. Our preliminary data indicates that areas of chronic underexposure exist today and the optimal delivery technique will be defined by our efforts in imaging and 3D animation & visualization of total body skin dose, developing an optimized imaging system to identify the ideal treatment technique for patients of different body shape. Finally, Cherenkov imaging is synergistic with scintillator imaging of dose, and this will be advanced as a related tool to remotely quantify skin dose. Taken together, this project will advance the only way to directly image radiotherapy dose and delivery on the patient’s tissue. The core of the project is combined technology systems, leveraging a large installed base of cameras and national partnerships advancing this field. This technology is embryonic but on the cusp of commercialization, where the focus of this research project being to advance the science and methods of where it can add value to radiotherapy. The long term benefit of advancing this technology will be to change the way in which radiotherapy incidents are observed by the therapist team and have these recorded on a daily basis in every treatment center.

抽象的 在人类中已经证明了放射治疗期间组织中从组织发射的光学成像， 提供与表面组织中辐射剂量相关的地图。在外束放射疗法中，信号 通过时间门控加强相机最佳捕获，与线性加速器脉冲同步，允许 拒绝大多数背景室灯光，并提供每种放射治疗的实时视频 标准剂量率。该发现与CT和反射率校准相结合有可能允许 在使用热辐射史上，人类首次在人类中进行准确的定量剂量成像。尽管 成像技术对表面区域有继承的局限性，这是一个实时成像工具和 提供治疗计划的每个功能的视觉记录是革命性的。它具有范式的潜力 改变放射疗法的记录和存档方式，以进行日常责任，质量审核以及潜在的责任 自动控制交付。 Cherenkov成像的实施比大多数 剂量学工具，但是需要建立对图像的理解和解释，以便 要清楚剂量输送剂量的可能性。这项提出的技术发展进步 使用我们专利的方法， CT/Cherenkov成像的CT/反射率校准将在常规处理中进行进展和测试。此外， 我们将提高与复杂多场治疗的患者成像的能力，相邻束场是 匹配，以便我们可以在比赛线上量化剂量准确性。另一个应用是总处理 具有电子疗法的皮肤，该领域非常大，因此成像剂量测定是有意义的。我们的 初步数据表明当今存在慢性不足的领域，并且最佳输送技术 我们将通过成像和3D动画和全身皮肤剂量的可视化的努力来定义 优化成像系统，以确定不同体形的患者的理想治疗技术。最后， Cherenkov成像与剂量的闪烁剂成像是协同的，这将是作为与 远程量化皮肤剂量。综上 在患者组织上的剂量和分娩。该项目的核心是联合技术系统，利用 大型安装摄像机和国家合作伙伴关系的基础在这一领域中前进。这项技术是胚胎，但 在商业化的风口浪尖上，该研究项目的重点是推进科学和 它可以为放射疗法增加价值的方法。推进这项技术的长期利益将是 更改治疗师团队观察到放疗事件的方式，并记录下来 每个治疗中心的每日基础。