OPTICAL CHERENKOV IMAGING DOSIMETRY IN HUMAN RADIOTHERAPY

人体放射治疗中的光学契伦科夫成像剂量测定

• 批准号: 10544455
• 负责人: David J. Gladstone
• 金额: $ 61.14万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10544455
• 关键词: 3-Dimensional; Accreditation; Advanced Development; Archives; Area; Breast; Calibration; Chronic; Clinical; Clinical Management; Complex; Core Grant; Data; Deposition; Development; Doctor of Philosophy; Dose; Dose-Rate; Electrons; Embryo; Engineering; Fatty acid glycerol esters; Funding; Geometry; Grant; Human; Image; Image Analysis; Imaging Device; Imaging technology; Institution; Leadership; Legal patent; Light; Linear Accelerator Radiotherapy Systems; Maps; Medical; Medicine; Methodology; Methods; Noise; Norris Cotton Cancer Center; Optics; Patient imaging; Patients; Physics; Physiologic pulse; Positioning Attribute; Property; Protons; Publications; Radiation; Radiation Dose Unit; Radiation Oncology; Radiation therapy; Recording of previous events; Research; Research Project Grants; Resources; Role; Scanning; Schools; Science; Shapes; Signal Transduction; Skin; Somatotype; Surface; System; Techniques; Technology; Testing; Therapeutic; Time; TimeLine; Tissues; Visual; Visualization; Work; animation; base; cherenkov imaging; clinically relevant; commercialization; design; dosimetry; experience; human imaging; human tissue; imaging facilities; imaging system; improved; innovation; oncology program; optical imaging; programs; quantitative imaging; real-time images; skin color; success; technology development; tool; treatment center; treatment optimization; treatment planning

ABSTRACT Optical imaging of Cherenkov emission from tissue during radiotherapy has been demonstrated in humans, providing a map correlated to radiation dose within the surface tissues. In external beam radiotherapy, the signal is optimally captured by time-gated intensified cameras, synchronized to the linear accelerator pulses, allowing rejection of the majority of background room light, and providing real time video of each radiotherapy treatment with standard dose rates. This discovery combined with CT and reflectance calibration has the potential to allow accurate quantitative dose imaging in humans for the first time in the history of therapeutic radiation use. While the imaging technology has inherent limitations to surface regions, the fact that it is a real time imaging tool and provide visual recording of every feature of a treatment plan is revolutionary. It has the potential for a paradigm change in how radiotherapy is documented and archived for daily reliance, quality audit and potentially automated control of delivery. The implementation of Cherenkov imaging is significantly simpler than most dosimetry tools, however the understanding and interpretation of the images need to be established, in order to be clear about what is possible in imaging delivery of dose. This proposed technology developments advance the methods for quantitative dose imaging in whole breast radiation treatment using our patented approach to CT/reflectance calibration of Cherenkov imaging, will be advanced and tested in regular treatments. Additionally, we will advance the ability to image patients with complex multi-field treatments, where adjacent beam fields are matched, so that we can quantify the dose accuracy at the match lines. Another application is treatment of total skin with electron therapy, where the field is extremely large and so imaging dosimetry makes sense. Our preliminary data indicates that areas of chronic underexposure exist today and the optimal delivery technique will be defined by our efforts in imaging and 3D animation & visualization of total body skin dose, developing an optimized imaging system to identify the ideal treatment technique for patients of different body shape. Finally, Cherenkov imaging is synergistic with scintillator imaging of dose, and this will be advanced as a related tool to remotely quantify skin dose. Taken together, this project will advance the only way to directly image radiotherapy dose and delivery on the patient’s tissue. The core of the project is combined technology systems, leveraging a large installed base of cameras and national partnerships advancing this field. This technology is embryonic but on the cusp of commercialization, where the focus of this research project being to advance the science and methods of where it can add value to radiotherapy. The long term benefit of advancing this technology will be to change the way in which radiotherapy incidents are observed by the therapist team and have these recorded on a daily basis in every treatment center.

抽象的 放射治疗过程中组织切伦科夫发射的光学成像已在人体中得到证实， 提供与表面组织内辐射剂量相关的图。在外束放射治疗中，信号 由时间选通增强相机最佳捕获，与线性加速器脉冲同步，从而允许 拒绝大部分房间背景光，并提供每次放射治疗的实时视频 与标准剂量率。这一发现与 CT 和反射率校准相结合，有可能使 在放射治疗使用历史上首次对人体进行精确的定量剂量成像。尽管 成像技术对表面区域具有固有的局限性，事实上它是一种实时成像工具，并且 提供治疗计划每个特征的视觉记录是革命性的。它具有成为典范的潜力 改变放射治疗的记录和归档方式，以供日常依赖、质量审核和潜在的使用 自动化控制交付。切伦科夫成像的实现比大多数成像要简单得多 剂量测定工具，但是需要建立对图像的理解和解释，以便 明确剂量成像传输的可能性。这项提议的技术发展进步 使用我们的专利方法在全乳腺放射治疗中进行定量剂量成像的方法 切伦科夫成像的 CT/反射率校准将在常规治疗中进行改进和测试。此外， 我们将提高通过复杂的多场治疗对患者进行成像的能力，其中相邻的射束场是 匹配，以便我们可以量化匹配线处的剂量精度。另一个应用是治疗总 采用电子疗法进行皮肤治疗，其电场非常大，因此成像剂量测定是有意义的。我们的 初步数据表明，目前存在长期暴露不足的区域以及最佳的输送技术 将通过我们在全身皮肤剂量的成像、3D 动画和可视化方面的努力来定义，开发 优化的成像系统，为不同体型的患者确定理想的治疗技术。最后， 切伦科夫成像与剂量闪烁体成像具有协同作用，这将作为相关工具得到发展 远程量化皮肤剂量。总而言之，该项目将推进直接成像放射治疗的唯一方法 剂量和递送到患者组织上。该项目的核心是组合技术系统，利用 庞大的摄像机安装基数和国家合作伙伴关系推动了这一领域的发展。这项技术还处于萌芽阶段，但 正处于商业化的风口浪尖，该研究项目的重点是推进科学和 可以为放射治疗增加价值的方法。推进这项技术的长期利益将是 改变治疗师团队观察放射治疗事件的方式并将其记录在案 每个治疗中心每天都会进行。