OPTICAL CHERENKOV IMAGING DOSIMETRY IN HUMAN RADIOTHERAPY

摘要 已经在人类身上证明了放射治疗期间组织的切伦科夫辐射的光学成像， 提供与表面组织内的辐射剂量相关的MAP。在外照射放射治疗中，信号 由时间门控增强相机最佳捕捉，与线性加速器脉冲同步，允许 拒绝大多数房间的背景光，并提供每次放射治疗的实时视频 有标准剂量率。这一发现与CT和反射率校准相结合，有可能使 在治疗放射使用史上第一次在人类身上进行准确的定量剂量成像。而当 成像技术对表面区域具有固有的限制，事实是它是一种实时成像工具和 提供治疗计划的每个功能的可视记录是革命性的。它有可能成为一种范例 改变记录和归档放射治疗的方式，以供日常依赖、质量审计和潜在的 自动控制交付。切伦科夫成像的实现比大多数 然而，需要建立对图像的理解和解释的剂量学工具，以便 要清楚在剂量的成像传递中可能发生的事情。这项拟议的技术发展取得了进展 在全乳腺放射治疗中使用我们的专利方法进行定量剂量成像的方法 切伦科夫成像的CT/反射校准，将在常规治疗中提前和测试。另外， 我们将提高通过复杂的多场治疗对患者进行成像的能力，其中邻近的束场是 匹配，这样我们就可以量化匹配线上的剂量精度。另一个应用是治疗TOTAL 皮肤电子治疗，在那里的视野非常大，所以成像剂量学是有意义的。我们的 初步数据表明，目前存在慢性暴露不足的领域，最佳提供技术 将通过我们在成像和3D动画以及身体皮肤总剂量的可视化方面的努力来定义，开发 优化成像系统，为不同体型的患者确定理想的治疗技术。最后， 切伦科夫成像与剂量闪烁体成像是协同作用的，这将作为一种相关工具来推进 远程量化皮肤剂量。综上所述，该项目将推进直接成像放射治疗的唯一途径 在病人组织上的剂量和投放。该项目的核心是组合技术系统，利用 大量安装的摄像头和推动这一领域的国家合作伙伴关系。这项技术还处于萌芽阶段，但 在商业化的边缘，这个研究项目的重点是推动科学和 它可以在哪里增加放射治疗的价值的方法。推进这项技术的长期好处将是 改变治疗师团队观察放射治疗事件的方式，并将这些记录在 在每个治疗中心每天都有。

ABSTRACT Optical imaging of Cherenkov emission from tissue during radiotherapy has been demonstrated in humans, providing a map correlated to radiation dose within the surface tissues. In external beam radiotherapy, the signal is optimally captured by time-gated intensified cameras, synchronized to the linear accelerator pulses, allowing rejection of the majority of background room light, and providing real time video of each radiotherapy treatment with standard dose rates. This discovery combined with CT and reflectance calibration has the potential to allow accurate quantitative dose imaging in humans for the first time in the history of therapeutic radiation use. While the imaging technology has inherent limitations to surface regions, the fact that it is a real time imaging tool and provide visual recording of every feature of a treatment plan is revolutionary. It has the potential for a paradigm change in how radiotherapy is documented and archived for daily reliance, quality audit and potentially automated control of delivery. The implementation of Cherenkov imaging is significantly simpler than most dosimetry tools, however the understanding and interpretation of the images need to be established, in order to be clear about what is possible in imaging delivery of dose. This proposed technology developments advance the methods for quantitative dose imaging in whole breast radiation treatment using our patented approach to CT/reflectance calibration of Cherenkov imaging, will be advanced and tested in regular treatments. Additionally, we will advance the ability to image patients with complex multi-field treatments, where adjacent beam fields are matched, so that we can quantify the dose accuracy at the match lines. Another application is treatment of total skin with electron therapy, where the field is extremely large and so imaging dosimetry makes sense. Our preliminary data indicates that areas of chronic underexposure exist today and the optimal delivery technique will be defined by our efforts in imaging and 3D animation & visualization of total body skin dose, developing an optimized imaging system to identify the ideal treatment technique for patients of different body shape. Finally, Cherenkov imaging is synergistic with scintillator imaging of dose, and this will be advanced as a related tool to remotely quantify skin dose. Taken together, this project will advance the only way to directly image radiotherapy dose and delivery on the patient’s tissue. The core of the project is combined technology systems, leveraging a large installed base of cameras and national partnerships advancing this field. This technology is embryonic but on the cusp of commercialization, where the focus of this research project being to advance the science and methods of where it can add value to radiotherapy. The long term benefit of advancing this technology will be to change the way in which radiotherapy incidents are observed by the therapist team and have these recorded on a daily basis in every treatment center.