Institutional Career Development Core

KL 2指导临床学者计划吸引了一群才华横溢的初级教师， 来自耶鲁大学的多个学科（医学院、护理学院、公共卫生学院、文学院 和科学，工程和应用科学）谁将追求T1-T4转化研究的职业生涯。这 该计划非常成功，吸引了151名学者，他们撰写了超过5200篇出版物， 在258 NIH赠款的PI，并已收到总额为5.57亿美元的赠款资金。值得注意的是，99%的 我们的KL 2学者在学术界，工业界或公共卫生领域获得了职位，并且经常与 临床和转化研究的领导责任。我们的目标是通过提供 在翻译研究方面接受个性化，基于能力的培训的学者， 有助于学习医疗保健系统，促进个性化健康，并解决健康差距。 这种准备包括临床试验，大数据，机器学习，生物信息学，多学科 转化研究、团队科学、实施科学和基于社区的参与性研究。它 还向他们介绍了监管问题，生物伦理学，良好的临床实践，以及驱动严格性的因素， 透明度和可复制性。KL 2促进了相关能力的发展， 学者通过提供：1）在复杂和多样化的多学科研究中成功工作的机会 团队，2）获得资深导师和最近的临床学者的指导，3）行业实习， 公共卫生和监管机构，以及4）在赠款写作和多学科团队的强化培训 科学为了监督这些多样化、积极性高的初级调查员，我们有一个教育领导层， 团队成员：1）三位在翻译研究的不同领域工作的杰出研究者导师，2）一位 经验丰富的多样性官员，3）评估和动态重塑医学教育的专家 程序.这个领导团队利用以前的学者和他们的导师的反馈来增加新的举措 已经成功的项目。我们扩展了我们的逻辑模型来实现社交网络分析， 跟踪学者的活动，我们将扩大课程，包括一个新的课程。该课程将 混合学者和TL-1学员谁将在团队中工作，因为他们得到正式的培训和同行指导， 各种领域，如大数据/机器学习，多样性和包容性，并运行研究实验室。 有了这些已经很强的课程，我们相信耶鲁指导临床学者 该计划将理想地定位于培养T1-T4转化研究的下一代领导者， 将以减轻疾病负担和改善美国及周边地区健康的方式改变医疗保健 世界KL 2的具体目标是： 目标1：耶鲁大学指导临床学者计划：提供一个由指导 研究经验，课程和研讨会，旨在促进科学的出现， 独立性和有才华的年轻T1-T4翻译科学家学者的职业发展。 目标2：耶鲁大学健康科学硕士课程：为那些医学博士。那些不具备 高级研究学位，额外的课程和学术活动，以获得硕士学位， 健康科学（MHS），以解决他们的科学准备的研究生涯的限制。

The KL2 Mentored Clinical Scholars Program attracts a diverse group of highly talented junior faculty across multiple disciplines from across Yale University (Schools of Medicine, Nursing, Public Health, Faculty of Arts and Sciences, Engineering and Applied Science) who will pursue careers in T1-T4 translational research. This Program has been extremely successful, attracting 151 Scholars who have authored >5200 publications, have been PIs on 258 NIH grants, and have received a total of $557 million in grant funding. Remarkably, 99% of our KL2 Scholars have attained positions in academia, industry or public health conducting, and often with leadership responsibilities for, clinical and translational research. We aim to build on this success by providing Scholars with individualized, competency-based training in translational research that prepares them to contribute to the learning healthcare system, to advance personalized health, and to address health disparities. This preparation includes training in clinical trials, big data, machine learning, bioinformatics, multidisciplinary translational research, team science, implementation science and community-based participatory research. It also introduces them to regulatory issues, bioethics, Good Clinical Practices, and factors that drive rigor, transparency, and replicability. The KL2 promotes the development of relevant competencies among the Scholars by providing: 1) opportunities to work successfully in complex and diverse multidisciplinary research teams, 2) access to mentorship by senior mentors and recent Clinical Scholars, 3) externships in industry, public health and regulatory agencies, and 4) intensive training in grant-writing and in multidisciplinary team science. To oversee these diverse, highly motivated junior investigators, we have an educational leadership team of: 1) three outstanding investigator mentors who work in different areas of translational research, 2) an experienced Diversity Officer, and 3) an expert in evaluating and dynamically reshaping medical education programs. This leadership team has used feedback from prior Scholars and their mentors to add new initiatives to the already successful program. We expanded our logic model to implement social network analyses to track the activities of the Scholars, and we will expand the curriculum to include a new course. That course will mix Scholars and TL-1 trainees who will work in teams as they get formal training and peer mentoring in a variety of areas such as big data/machine learning, diversity and inclusion, and running a research laboratory. With these additions to an already strong curriculum, we believe that the Yale Mentored Clinical Scholars Program will be ideally positioned to train the next generation of leaders in T1-T4 translational research who will transform healthcare in ways that alleviate the burden of disease and improve health in the US and around the world. The Specific Aims of the KL2 are: Aim 1: The Yale Mentored Clinical Scholars Program: To provide a program comprised of a mentored research experience, coursework, and seminars that are intended to promote the emergence of scientific independence and the career development of talented young T1-T4 translational scientist Scholars. Aim 2: The Yale Masters in Health Science Program: To provide those M.D. Scholars who do not possess an advanced research degree with additional coursework and scholarly activities to qualify for a Masters in Health Science (MHS) to address limitations in their scientific preparation for a research career.