Validation of Video Administration of a Modified UDSv3 Cognitive Battery

改进的 UDSv3 认知电池的视频管理验证

• 批准号: 10370578
• 负责人: STEPHEN R RAPP
• 金额: $ 146.75万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10370578
• 关键词: Academic Medical Centers; Achievement; Acute Respiratory Distress Syndrome; Address; Advisory Committees; Affect; Age; Agreement; Alzheimer' s Disease; Amyotrophic Lateral Sclerosis; Assessment tool; Attention; COVID-19 pandemic; Characteristics; Classification; Clinical; Cognition; Cognitive; Data; Data Collection; Data Set; Dementia; Education; Elderly; Enrollment; Episodic memory; Ethnic Origin; Evaluation; Failure; Financial Hardship; Frail Elderly; Future; Geographic Locations; Geography; Goals; Gold; Individual; Interruption; Language; Measures; Medical center; Minority; Modality; Neuropsychology; Outcome; Participant; Persons; Population; Protocols documentation; Psychometrics; Race; Research; Rural Population; Short-Term Memory; Site; Standardization; Subgroup; Tablet Computer; Telephone; Testing; Time; Transportation; Traumatic Brain Injury; Travel; Underserved Population; United States National Institutes of Health; Update; Validation; Visit; adjudicate; adjudication; base; clinical care; cognitive testing; ethnic minority; executive function; forest; meetings; metropolitan; mild cognitive impairment; preference; prevent; programs; racial and ethnic; recruit; remote assessment; remote grading; response; satisfaction; success; tool; virtual; working group

Project Summary This multi-site R01 aims to validate video-administered cognitive assessments for use by the Alzheimer’s Disease Research Centers (ADRCs) and other research programs whose activities have been interrupted by the COVID-19 pandemic, as well as for use in future initiatives when remote testing will enhance achievement of scientific goals. While face-to-face administration is the gold standard for cognitive assessments, conditions often arise that prevent participants from attending in-person visits. These barriers include transportation challenges, limited mobility, and financial hardship. There is also evidence that underserved populations, including rural populations and racial/ethnic minorities, are less likely to enroll in studies that require travel to an academic medical center for face-to-face testing. The proposed study will address these challenges by utilizing a video-adapted battery incorporating the Uniform Data Set version 3 (UDSv3) measures with additional measures that may serve as alternatives for UDSv3 measures not adaptable to video administration. We propose to fully validate these assessment tools for remote administration in partnership with the NIA and the National Alzheimer’s Coordinating Center (NACC), and carried out by a consortium of 12 ADRCs. Pilot data was gathered from 88 Wake Forest ADRC participants, deemed by in-person testing and adjudication to have normal cognition, MCI, or dementia, who were tested either by phone or video. Data show high participant ratings of tolerability, feasibility, and preference for video versus telephone assessment. There is also high concordance between video-administered and in- person test scores. Based on this collective data, we plan to fully validate a video-version of the UDSv3 battery in a range of cognitively, ethnically, and geographically diverse participants. We propose to administer remote video cognitive assessments, paired alongside annual in-person cognitive assessments, in counterbalanced order, to 500 existing participants from 12 ADRCs utilizing a computer tablet device, including those previously adjudicated as having normal cognition, MCI and dementia. Participants’ ratings of satisfaction with test condition and preference of test modality will be obtained, in addition to the psychometric characteristics of the video battery relative to face-to-face administration, including concurrent validity, and estimates of relative bias overall and across important subgroups (age, ethnicity, cognitive status) and mode of administration of individual tests. Concordance between adjudication outcomes will also be examined to assess the ability of the battery to distinguish normal cognition, MCI and dementia. We will assess the sensitivity of the video battery to detect longitudinal change in cognition in ADRC participants by repeating counterbalanced, in-person and remote assessments 2 years following initial evaluation. Completion of this project is critical to the ongoing success of cognitive assessment in the ADRC network.

项目摘要 此多站点R01旨在验证视频管理的认知评估，供 阿尔茨海默病研究中心(ADRC)和其他研究项目，其活动已经 被新冠肺炎大流行中断，并用于未来远程测试将增强的倡议中 科学目标的实现。而面对面的管理是认知的黄金标准 在评估过程中，经常会出现妨碍参与者亲自到访的情况。这些障碍 包括交通挑战、有限的流动性和经济困难。也有证据表明 服务不足的人口，包括农村人口和种族/族裔少数群体，不太可能参加 需要前往学术医疗中心进行面对面测试的研究。拟议的研究将 通过使用包含统一数据集版本3的视频适配电池来应对这些挑战 (UDSv3)可用作UDSv3措施的替代措施的附加措施注意 适用于视频管理。我们建议全面验证这些远程评估工具 与NIA和国家阿尔茨海默氏症协调中心(NACC)合作的行政部门，以及 由12个ADRC组成的财团进行。试点数据收集自88名维克森林ADRC参与者， 被当面测试和判定为具有正常认知、MCI或痴呆症的人 要么通过电话，要么通过视频。数据显示，参与者对视频的容忍度、可行性和偏好的评分较高 与电话评估相比。视频管理和In-In之间也有很高的一致性- 个人测试分数。基于这些收集的数据，我们计划全面验证UDSv3的视频版本 对一系列认知、种族和地理上不同的参与者进行了调查。我们建议管理 远程视频认知评估，与年度面对面认知评估配合使用， 向来自12个ADRC的500名现有参与者发出平衡订单，使用计算机平板设备，包括 那些之前被判定为认知正常、MCI和痴呆症的人。参与者的评分为 此外，还将获得对测试条件和测试方式偏好的满意度 视频电池相对于面对面给药的心理测量特征，包括 同时效度，以及对总体和跨重要分组的相对偏差的估计(年龄、种族、 认知状态)和单项测试的管理模式。裁决之间的一致性 还将检查结果，以评估电池区分正常认知、MCI和 痴呆症。我们将评估视频电池检测ADRC患者认知纵向变化的灵敏度 参与者在初始评估后2年重复平衡、面对面和远程评估 评估。该项目的完成对于ADRC认知评估的持续成功至关重要。 网络。