Validation of Video Administration of a Modified UDSv3 Cognitive Battery

项目摘要 这一多中心R 01旨在验证视频管理的认知评估， 阿尔茨海默病研究中心（ADRC）和其他研究计划，其活动已被 由于COVID-19大流行而中断，以及在未来远程测试将加强的情况下使用 实现科学目标。虽然面对面的管理是认知的黄金标准， 在评估过程中，常常出现阻止参与者亲自参加访问的情况。这些障碍 包括交通困难、流动性有限和经济困难。也有证据表明 服务不足的人口，包括农村人口和种族/少数民族， 需要前往学术医疗中心进行面对面测试的研究。拟定的研究将 通过使用一个视频适配电池来解决这些挑战，该电池包括统一数据集第3版 （UDSv 3）措施以及可能作为UDSv 3措施替代的其他措施， 适合视频管理。我们建议充分验证这些评估工具， 与NIA和国家阿尔茨海默氏症协调中心（NACC）合作管理， 由12个ADRC组成的联合体进行。试点数据收集自88名维克森林ADRC参与者， 通过亲自测试和裁定被认为具有正常认知、MCI或痴呆， 通过电话或视频。数据显示，参与者对视频的耐受性、可行性和偏好的评分很高 与电话评估相比。视频管理和内部管理之间的一致性也很高， 个人测试成绩。基于这些收集的数据，我们计划全面验证UDSv 3的视频版本 一系列认知、种族和地理上不同的参与者的电池。我们建议管理 远程视频认知评估，与年度面对面认知评估配对， 平衡秩序，500名现有参与者从12个ADRC利用电脑平板电脑设备，包括 那些先前被判定为具有正常认知、MCI和痴呆的人。参与者对 此外，还将获得对测试条件的满意度和对测试方式的偏好 与面对面管理相关的视频电池的心理测量特征，包括 同时有效性，以及总体和重要亚组（年龄，种族， 认知状态）和个体测试的施用方式。裁定之间的一致性 结果也将被检查，以评估电池区分正常认知，MCI和 痴呆我们将评估视频电池检测ADRC中认知纵向变化的敏感性 通过在初次评估后2年重复进行平衡评估、面对面评估和远程评估， 评价这个项目的完成对ADRC认知评估的持续成功至关重要 网络

Project Summary This multi-site R01 aims to validate video-administered cognitive assessments for use by the Alzheimer’s Disease Research Centers (ADRCs) and other research programs whose activities have been interrupted by the COVID-19 pandemic, as well as for use in future initiatives when remote testing will enhance achievement of scientific goals. While face-to-face administration is the gold standard for cognitive assessments, conditions often arise that prevent participants from attending in-person visits. These barriers include transportation challenges, limited mobility, and financial hardship. There is also evidence that underserved populations, including rural populations and racial/ethnic minorities, are less likely to enroll in studies that require travel to an academic medical center for face-to-face testing. The proposed study will address these challenges by utilizing a video-adapted battery incorporating the Uniform Data Set version 3 (UDSv3) measures with additional measures that may serve as alternatives for UDSv3 measures not adaptable to video administration. We propose to fully validate these assessment tools for remote administration in partnership with the NIA and the National Alzheimer’s Coordinating Center (NACC), and carried out by a consortium of 12 ADRCs. Pilot data was gathered from 88 Wake Forest ADRC participants, deemed by in-person testing and adjudication to have normal cognition, MCI, or dementia, who were tested either by phone or video. Data show high participant ratings of tolerability, feasibility, and preference for video versus telephone assessment. There is also high concordance between video-administered and in- person test scores. Based on this collective data, we plan to fully validate a video-version of the UDSv3 battery in a range of cognitively, ethnically, and geographically diverse participants. We propose to administer remote video cognitive assessments, paired alongside annual in-person cognitive assessments, in counterbalanced order, to 500 existing participants from 12 ADRCs utilizing a computer tablet device, including those previously adjudicated as having normal cognition, MCI and dementia. Participants’ ratings of satisfaction with test condition and preference of test modality will be obtained, in addition to the psychometric characteristics of the video battery relative to face-to-face administration, including concurrent validity, and estimates of relative bias overall and across important subgroups (age, ethnicity, cognitive status) and mode of administration of individual tests. Concordance between adjudication outcomes will also be examined to assess the ability of the battery to distinguish normal cognition, MCI and dementia. We will assess the sensitivity of the video battery to detect longitudinal change in cognition in ADRC participants by repeating counterbalanced, in-person and remote assessments 2 years following initial evaluation. Completion of this project is critical to the ongoing success of cognitive assessment in the ADRC network.