Identifying Modifiable Practices Related to Outcome Variation and Enhancement in Transcatheter Aortic Valve Replacement (IMPROVE TAVR)

确定与经导管主动脉瓣置换术结果变化和增强相关的可修改实践(IMPROVE TAVR)

基本信息

  • 批准号:
    10370068
  • 负责人:
  • 金额:
    $ 19.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-01-21 至 2026-12-31
  • 项目状态:
    未结题

项目摘要

Project Summary/Abstract Approximately 12.4% of patients >75 years of age have aortic stenosis (AS) and 3.4% have severe AS. Transcatheter aortic valve replacement (TAVR) has emerged as a safe and effective therapeutic option for patients with symptomatic severe AS. More than 50,000 TAVRs are now performed annually across >500 hospitals in the United States (US). Despite stringent patient selection criteria and standardized procedural techniques, there remains significant hospital variation in outcomes, including mortality, morbidity, and readmissions, following TAVR in the US. However, the reasons underlying hospital variation in TAVR outcomes remain poorly understood. Identifying organizational practices and processes of care associated with better outcomes is critical to improve the overall outcomes of patients undergoing TAVR. The overarching objective of this proposal is to perform a mixed methods study using a positive deviance approach to understand determinants of hospital variation in TAVR outcomes and to identify modifiable practices associated with improved outcomes. In Aim 1, we will use data from the Transcatheter Valve Therapy Registry to identify high- and low-performing TAVR hospitals based on variation in two key patient-centered outcomes after TAVR – 30-day major adverse events (MAE, defined as a global ranked composite of mortality, stroke, major/life-threatening bleeding, acute kidney injury stage 3, and moderate/severe paravalvular leak) and 30- day readmissions. In Aim 2, we will conduct in-depth, semi-structured interviews of key clinical and administrative staff involved in the care of TAVR patients in a representative sample of high- and low- performing hospitals. The qualitative data will be analyzed to identify specific themes associated with high performance, and to develop two distinct conceptual models of factors influencing MAE and readmissions, respectively, after TAVR. This study will identify ‘best practices’ that can be adopted by low-performing and new TAVR programs to improve their patient outcomes. Further, this research has the potential to identify clear evidence-based structure and process measures that can inform guidelines and policies on evaluation of the quality of TAVR and other transcatheter valve intervention programs. This research will be accomplished in the setting of a comprehensive career development plan designed to provide Dr. Kolte, an early career investigator, with the training and skills necessary to achieve his long-term career goal of becoming an independent clinician-investigator with expertise in cardiovascular outcomes and mixed methods research in the field of transcatheter heart valve interventions. An outstanding mentoring team and scientific advisory committee of established investigators in the fields of valvular heart disease, outcomes research, quantitative methods, and qualitative/mixed methods research will guide Dr. Kolte in his transition to independence over the course of the award period.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Dhaval Sanjeev Kolte其他文献

Dhaval Sanjeev Kolte的其他文献

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{{ truncateString('Dhaval Sanjeev Kolte', 18)}}的其他基金

Identifying Modifiable Practices Related to Outcome Variation and Enhancement in Transcatheter Aortic Valve Replacement (IMPROVE TAVR)
确定与经导管主动脉瓣置换术结果变化和增强相关的可修改实践(IMPROVE TAVR)
  • 批准号:
    10553689
  • 财政年份:
    2022
  • 资助金额:
    $ 19.23万
  • 项目类别:

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