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Northwestern CORE Clinical Research Site: Trans-omics for HIV/AIDS Research

西北核心临床研究站点：艾滋病毒/艾滋病研究的跨组学

基本信息

批准号：
10371187
负责人：
Steven M Wolinsky
金额：
$ 386.2万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-10 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10371187
关键词：
AIDS/HIV problem Active Sites Address Advocacy Aging Basic Science Behavior Big Data Biological Assay Biological Factors Biological Markers Biological Process Biology Blood Blood specimen Catalogs Cells Chronic Clinical Clinical Research Cohort Studies Collaborations Collection Communities Complement Complex County Data Data Analyses Data Collection Data Set Development Diagnosis Disease Disease Outcome Disease model Enrollment Ensure Epidemic Event Funding Gene Expression Gene Expression Profile Genes Genetic Genetic Determinism Genetic Risk Genome Genotype Goals HIV HIV Infections Health Health Insurance Portability and Accountability Act Health Policy Healthcare Heritability Hospitals Human Image Immune System Diseases Immune response Infection Inflammation Inflammation Mediators Inflammatory Information Technology Informed Consent Infrastructure Interdisciplinary Study Knowledge Laboratories Lead Leadership Link Maintenance Measures Medical Records Modeling Modeling of Functional Interactions Molecular Profiling Office of Administrative Management Outcome Participant Pathogenicity Pathway Analysis Pathway interactions Pattern Persons Pharmaceutical Preparations Phenotype Play Policies Policy Developments Practice Guidelines Precision Medicine Initiative Predisposition Procedures Production Property Prospective Studies Protocols documentation Psychosocial Factor Public Health Quality Control Recording of previous events Reporting Reproducibility Research Research Priority Research Project Grants Resources Risk Role Running Science Scientific Advances and Accomplishments Scientist Severity of illness Signal Pathway Signaling Protein System Testing Tissues Training United States National Institutes of Health Universities Variant Virus Virus Replication Work adjudicate adjudication base clinical care clinical research site co-infection cohort comorbidity cooking data integration epidemiology study flexibility follow-up functional genomics genetic variant good laboratory practice immune activation improved inclusion criteria innovation insight microbiome multidisciplinary new therapeutic target next generation novel participant enrollment participant retention patient engagement predictive modeling programs protein expression protein protein interaction quality assurance repository response risk variant sample collection social science research vaccine development virus host interaction

项目摘要

The Northwestern University and the Ruth M. Rothstein CORE Center of the Cook County Health & Hospitals System Clinical Research Site (NC CRS) addresses the highest research priorities in HIV/AIDS research through retention and maintenance of the cohort, collection and repository storage of blood samples, and development and implementation of the unified science agenda. Through the leadership we provide and the data and blood samples we collect, the NC CRS actively contributes to core protocols and thematic sub- studies to characterize the long-term, natural and treated history of HIV infection in a representative cohort of people at substantial risk of becoming infected with the virus. We strictly adhere to good practice guidelines, established policies and procedures, and robust quality assurance and quality control measures to ensure the accuracy, reproducibility, and integrity of the clinical and laboratory data and blood samples. Scientific and administrative management provides both the flexibility and means to conduct multidisciplinary research projects as well as the resources to respond rapidly to recent scientific progress. For the past 35 years, we have maintained a comprehensive portfolio of biomedical and social science research on HIV and its related coinfections, comorbidities, and other complications. The diversity of the work makes possible a broad and multidisciplinary view of these high priority topics for understanding the basic biology of HIV, immune dysfunction and chronic inflammation, and genetic determinants. Scientific questions take full advantage of the strengths of the cohort, namely, its duration and the continuity of data and blood samples that timespan provides. Data and blood samples are available from people before and after infection, before and after beginning medications, or before and after the development of comorbidities or their complications. Productive relationships across the combined cohort, as well as other consortia and organizations, have coalesced around specific issues to advance scientific knowledge, the health of people, and policy development. By capitalizing on the expertise and unique resources of a multidisciplinary team of experts, we will build on our studies of genome sequence, patterns of gene and protein expression, and metabolite concentrations and changes (trans-omics dataset), along with information from people's medical records, to identify genes and pathways that play a role in disease and determine how they interact with HIV. Hierarchal models that predict the network behavior that gives rise to a phenotype will unravel the complexity of disease to provide novel and important insights into biological processes for testing or generating a set of hypotheses about disease mechanisms. During the next 7-year funding cycle, the NC CRS will continue support for the cohort and trans- omics for HIV/AIDS research that complements and extends the NIH Precision Medicine Initiative that connects genotype and phenotype and aligns with the NIH Big Data Initiative that supports innovative and transformative approaches to advance understanding of human health and disease.

西北大学和库克县健康与医院的露丝·m·罗斯坦核心中心