Northwestern CORE Clinical Research Site: Trans-omics for HIV/AIDS Research

西北大学和库克县卫生与医院的露丝·M·罗斯坦核心中心 系统临床研究网站(NC CRS)致力于艾滋病毒/艾滋病研究的最高优先研究 通过保留和维护血液样本的队列、收集和储存库，以及 制定和实施统一科学议程。通过我们提供的领导力和 我们收集的数据和血液样本，全国委员会研究报告积极促进核心议定书和专题分项目。 在一个具有代表性的队列中研究HIV感染的长期、自然和治疗史 有很大风险感染病毒的人。我们严格遵守良好做法指南， 既定的政策和程序，以及强有力的质量保证和质量控制措施，以确保 临床和实验室数据及血液样本的准确性、重复性和完整性。科学和 行政管理为开展多学科研究提供了灵活性和手段 项目和资源，以便对最近的科学进步作出快速反应。在过去35年里，我们 保持了关于艾滋病毒及其相关的生物医学和社会科学研究的全面组合 合并感染、合并症和其他并发症。作品的多样性使广泛的和 多学科观点，了解艾滋病毒、免疫的基本生物学 功能障碍和慢性炎症，以及遗传决定因素。科学问题充分利用了 队列的优势，即其持续时间以及数据和血液样本的连续性 提供了。人们可以在感染前和感染后、感染前和感染后获得数据和血液样本 开始服药，或在出现合并症或其并发症前后。多产 合并后的队列以及其他财团和组织的关系已经凝聚在一起 促进科学知识、人民健康和政策制定的具体问题。通过大写 在多学科专家团队的专业知识和独特资源的基础上，我们将在 基因组序列、基因和蛋白质表达模式以及代谢物浓度和变化 (转组学数据集)，以及来自人们医疗记录的信息，以识别基因和途径 它们在疾病中发挥作用，并决定它们如何与艾滋病毒相互作用。预测的分层模型 引发表型的网络行为将揭开疾病的复杂性，为人类提供新颖和 对测试或生成一组关于疾病的假说的生物学过程的重要见解 机械装置。在下一个7年筹资周期内，全国社区合作与发展中心将继续支持这一群体和运输方案。 艾滋病毒/艾滋病研究的组学，补充和扩展NIH精密医学倡议，该倡议 将基因型和表型联系起来，并与NIH大数据计划保持一致，该计划支持创新和 促进对人类健康和疾病的了解的变革性方法。

The Northwestern University and the Ruth M. Rothstein CORE Center of the Cook County Health & Hospitals System Clinical Research Site (NC CRS) addresses the highest research priorities in HIV/AIDS research through retention and maintenance of the cohort, collection and repository storage of blood samples, and development and implementation of the unified science agenda. Through the leadership we provide and the data and blood samples we collect, the NC CRS actively contributes to core protocols and thematic sub- studies to characterize the long-term, natural and treated history of HIV infection in a representative cohort of people at substantial risk of becoming infected with the virus. We strictly adhere to good practice guidelines, established policies and procedures, and robust quality assurance and quality control measures to ensure the accuracy, reproducibility, and integrity of the clinical and laboratory data and blood samples. Scientific and administrative management provides both the flexibility and means to conduct multidisciplinary research projects as well as the resources to respond rapidly to recent scientific progress. For the past 35 years, we have maintained a comprehensive portfolio of biomedical and social science research on HIV and its related coinfections, comorbidities, and other complications. The diversity of the work makes possible a broad and multidisciplinary view of these high priority topics for understanding the basic biology of HIV, immune dysfunction and chronic inflammation, and genetic determinants. Scientific questions take full advantage of the strengths of the cohort, namely, its duration and the continuity of data and blood samples that timespan provides. Data and blood samples are available from people before and after infection, before and after beginning medications, or before and after the development of comorbidities or their complications. Productive relationships across the combined cohort, as well as other consortia and organizations, have coalesced around specific issues to advance scientific knowledge, the health of people, and policy development. By capitalizing on the expertise and unique resources of a multidisciplinary team of experts, we will build on our studies of genome sequence, patterns of gene and protein expression, and metabolite concentrations and changes (trans-omics dataset), along with information from people's medical records, to identify genes and pathways that play a role in disease and determine how they interact with HIV. Hierarchal models that predict the network behavior that gives rise to a phenotype will unravel the complexity of disease to provide novel and important insights into biological processes for testing or generating a set of hypotheses about disease mechanisms. During the next 7-year funding cycle, the NC CRS will continue support for the cohort and trans- omics for HIV/AIDS research that complements and extends the NIH Precision Medicine Initiative that connects genotype and phenotype and aligns with the NIH Big Data Initiative that supports innovative and transformative approaches to advance understanding of human health and disease.