Subcortical and Cortical Responses in Infants Evoked by Running Speech

婴儿跑步言语引起的皮质下和皮质反应

• 批准号: 10373228
• 负责人: Ross K Maddox
• 金额: $ 21.04万
• 依托单位: SYRACUSE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10373228
• 关键词: Acoustic Nerve; Acoustics; Address; Adult; Affect; Age; Auditory; Auditory Brainstem Responses; Auditory Evoked Potentials; Auditory area; Auditory system; Biological Markers; Brain Stem; Child; Clinical; Code; Communication; Communication impairment; Data; Development; Effectiveness; Event; Frequencies; Gestational Age; Goals; Hearing; Human Development; Infant; Interruption; Laboratories; Language; Language Delays; Language Development; Lateral lemniscus; Lead; Learning; Length; Life; Literature; Measurement; Measures; Methods; Midbrain structure; Nervous system structure; Newborn Infant; Pathway interactions; Performance; Physiological; Premature Infant; Process; Protocols documentation; Research; Response Latencies; Running; Scientific Inquiry; Signal Transduction; Social Interaction; Speech; Speech Perception; Stimulus; System; Techniques; Testing; Training; Validation; Voice; auditory processing; autism spectrum disorder; base; complement system; disability; experience; falls; innovation; insight; millisecond; myelination; neural network; neurodevelopment; novel; perinatal period; potential biomarker; relating to nervous system; response; sound; speech processing; tool

Efficient subcortical and cortical auditory processing is integral for learning spoken language. The goal of this project is to use a new tool we have developed to investigate responses to natural speech across the auditory hierarchy. Effective coding of the dynamic speech signal during development partially drives cortical development, and auditory neural deficits contribute to lifelong listening disabilities. While there are methods for measuring responses from the brainstem by the auditory brainstem response (ABR) and from the cortex (central auditory evoked potentials [CAEP]) in infants, only very short sounds can be used to evoke them which lack the complexity and richness of natural speech. Measurement of auditory responses to continuous, natural speech measured from the periphery through the brainstem and cortex opens the door for a broad spectrum of scientific inquiries including speech perception, language acquisition, and auditory processing deficits underlying various types of communication disorders. Despite the traditional stimulus limitations, the decrease in ABR and CAEP wave latencies and the increase in wave amplitudes with increasing infant age is used as a measure of maturation of brainstem myelination and cortical development for scientific and clinical purposes. Typically, only one or the other is measured, because they require different acquisition protocols. To address the limitations in non-natural stimuli and inability to measure brainstem and cortical responses simultaneously, the Maddox laboratory has pioneered a technique to measure the ABR and CAEP simultaneously to natural, running speech and shown its effectiveness in adults. In this project we will validate the technique in newborns and young infants, and define the relationship between brainstem and cortical responses over the first five months of life. In the first aim, we test the hypothesis that the novel speech ABR reflects auditory brainstem maturation. We hypothesize that the latencies of the response waves correlate with gestational age in term and preterm infants. We expect that there will be a relationship between click and speech ABR latencies, but that the developmental trajectory may be different, thereby providing new, complementary information. Based on previous literature, we also expect that trajectories will be different for term and preterm infants. In the second specific aim, we will characterize the cortical responses in infants and test the hypothesis that the size and latency of cortical responses to ongoing speech is dependent both on gestational age and wave latencies of the speech ABR. We also hypothesize that the relationships will be different for term and preterm infants. This aim is made possible by a major advantage of our speech response measure over traditional methods: the same data from which the ABR is derived also provides cortical responses. This innovative study will be the first to obtain auditory physiological measures of natural, running speech in developing infants from the brainstem to the cortex. This high-impact project will drive new studies of language acquisition and identify potential biomarkers for communication disorders due to underlying auditory processing deficiencies.

有效的皮层下和皮层听觉处理对于学习口语至关重要。此举的目标 该项目是使用我们开发的一种新工具来调查整个听觉领域对自然语音的反应 等级制度。发育过程中动态语音信号的有效编码部分驱动皮质 发育和听觉神经缺陷会导致终身听力障碍。虽然有方法 用于通过听觉脑干反应 (ABR) 和皮层测量脑干的反应 （中枢听觉诱发电位 [CAEP]）对于婴儿来说，只能使用非常短的声音来唤起它们 缺乏自然语音的复杂性和丰富性。测量对连续、自然的听觉反应 通过脑干和皮层从外围测量的言语为广泛的 科学探究，包括言语感知、语言习得和听觉处理缺陷 潜在的各种类型的沟通障碍。尽管传统的刺激措施有限制，但经济增长的减少 ABR 和 CAEP 波潜伏期和波幅随着婴儿年龄的增加而增加被用作 用于科学和临床目的的脑干髓鞘形成和皮质发育成熟度的测量。 通常，仅测量其中之一，因为它们需要不同的采集协议。致地址 非自然刺激的局限性以及无法同时测量脑干和皮质反应， Maddox 实验室开创了一种同时测量天然 ABR 和 CAEP 的技术， 运行语音并在成人中显示出其有效性。在这个项目中，我们将在新生儿中验证该技术 和小婴儿，并定义前五年脑干和皮质反应之间的关系 几个月的生命。第一个目标是检验新颖语音 ABR 反映听觉脑干的假设 成熟。我们假设响应波的潜伏期与足月和胎龄相关。 早产儿。我们预计点击和语音 ABR 延迟之间存在关系，但是 发展轨迹可能不同，从而提供新的补充信息。基于 根据之前的文献，我们还预计足月儿和早产儿的轨迹会有所不同。在第二个 为了实现特定目标，我们将描述婴儿的皮质反应特征，并检验以下假设：婴儿的大小和 皮质对正在进行的言语反应的潜伏期取决于胎龄和大脑波的潜伏期。 语音 ABR。我们还假设足月儿和早产儿的关系会有所不同。这个目标是 与传统方法相比，我们的语音响应测量的一个主要优势使之成为可能：相同的数据 ABR 的来源也提供皮质反应。这项创新研究将是第一个获得 发育中的婴儿从脑干到大脑的自然、连续言语的听觉生理测量 皮质。这个具有高影响力的项目将推动语言习得的新研究并确定潜在的生物标志物 由于潜在的听觉处理缺陷而导致的沟通障碍。