Subcortical and Cortical Responses in Infants Evoked by Running Speech

婴儿跑步言语引起的皮质下和皮质反应

• 批准号: 10373228
• 负责人: Ross K Maddox
• 金额: $ 21.04万
• 依托单位: SYRACUSE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10373228
• 关键词: Acoustic Nerve; Acoustics; Address; Adult; Affect; Age; Auditory; Auditory Brainstem Responses; Auditory Evoked Potentials; Auditory area; Auditory system; Biological Markers; Brain Stem; Child; Clinical; Code; Communication; Communication impairment; Data; Development; Effectiveness; Event; Frequencies; Gestational Age; Goals; Hearing; Human Development; Infant; Interruption; Laboratories; Language; Language Delays; Language Development; Lateral lemniscus; Lead; Learning; Length; Life; Literature; Measurement; Measures; Methods; Midbrain structure; Nervous system structure; Newborn Infant; Pathway interactions; Performance; Physiological; Premature Infant; Process; Protocols documentation; Research; Response Latencies; Running; Scientific Inquiry; Signal Transduction; Social Interaction; Speech; Speech Perception; Stimulus; System; Techniques; Testing; Training; Validation; Voice; auditory processing; autism spectrum disorder; base; complement system; disability; experience; falls; innovation; insight; millisecond; myelination; neural network; neurodevelopment; novel; perinatal period; potential biomarker; relating to nervous system; response; sound; speech processing; tool

Efficient subcortical and cortical auditory processing is integral for learning spoken language. The goal of this project is to use a new tool we have developed to investigate responses to natural speech across the auditory hierarchy. Effective coding of the dynamic speech signal during development partially drives cortical development, and auditory neural deficits contribute to lifelong listening disabilities. While there are methods for measuring responses from the brainstem by the auditory brainstem response (ABR) and from the cortex (central auditory evoked potentials [CAEP]) in infants, only very short sounds can be used to evoke them which lack the complexity and richness of natural speech. Measurement of auditory responses to continuous, natural speech measured from the periphery through the brainstem and cortex opens the door for a broad spectrum of scientific inquiries including speech perception, language acquisition, and auditory processing deficits underlying various types of communication disorders. Despite the traditional stimulus limitations, the decrease in ABR and CAEP wave latencies and the increase in wave amplitudes with increasing infant age is used as a measure of maturation of brainstem myelination and cortical development for scientific and clinical purposes. Typically, only one or the other is measured, because they require different acquisition protocols. To address the limitations in non-natural stimuli and inability to measure brainstem and cortical responses simultaneously, the Maddox laboratory has pioneered a technique to measure the ABR and CAEP simultaneously to natural, running speech and shown its effectiveness in adults. In this project we will validate the technique in newborns and young infants, and define the relationship between brainstem and cortical responses over the first five months of life. In the first aim, we test the hypothesis that the novel speech ABR reflects auditory brainstem maturation. We hypothesize that the latencies of the response waves correlate with gestational age in term and preterm infants. We expect that there will be a relationship between click and speech ABR latencies, but that the developmental trajectory may be different, thereby providing new, complementary information. Based on previous literature, we also expect that trajectories will be different for term and preterm infants. In the second specific aim, we will characterize the cortical responses in infants and test the hypothesis that the size and latency of cortical responses to ongoing speech is dependent both on gestational age and wave latencies of the speech ABR. We also hypothesize that the relationships will be different for term and preterm infants. This aim is made possible by a major advantage of our speech response measure over traditional methods: the same data from which the ABR is derived also provides cortical responses. This innovative study will be the first to obtain auditory physiological measures of natural, running speech in developing infants from the brainstem to the cortex. This high-impact project will drive new studies of language acquisition and identify potential biomarkers for communication disorders due to underlying auditory processing deficiencies.

有效的皮层下和大脑皮层听觉处理对于学习口语是不可或缺的。这样做的目的是 项目是使用我们开发的一种新工具来研究听觉上对自然语言的反应 层级结构。在发育期间对动态语音信号的有效编码部分地驱动皮层 发育障碍和听神经缺陷会导致终生听力障碍。虽然有一些方法 用于通过听性脑干反应(ABR)测量脑干和大脑皮层的反应 (中枢性听觉诱发电位[CAEP])在婴儿中，只有非常短的声音可以用来唤醒他们， 缺乏自然语言的复杂性和丰富性。对连续、自然的听觉反应的测量 从外围通过脑干和皮质测量的语音为广泛的 包括言语感知、语言习得和听觉处理缺陷在内的科学探究 各种沟通障碍的潜在原因。尽管传统的刺激措施存在局限性，但减少 在ABR和CAEP中，波的潜伏期和波幅随婴儿年龄的增加而增加 为了科学和临床目的，测量脑干髓鞘形成和皮质发育的成熟程度。 通常，只测量其中之一，因为它们需要不同的采集协议。致信地址 非自然刺激的局限性以及无法同时测量脑干和皮质反应， Maddox实验室开创了一项同时测量ABR和CAEP的技术， 跑步演讲，并在成年人身上展示了它的有效性。在这个项目中，我们将在新生儿身上验证这项技术 和幼儿，并定义前五个阶段脑干和皮质反应之间的关系 几个月的生命。在第一个目标中，我们检验了新的语音ABR反映听觉脑干的假设 成熟。我们假设反应波的潜伏期与足月和胎龄相关。 早产儿。我们预计点击和语音ABR延迟之间会有关系，但 发展轨迹可能不同，从而提供新的补充信息。基于 在以前的文献中，我们也预计足月儿和早产儿的轨迹会不同。在第二个 具体地说，我们将描述婴儿的皮质反应，并测试大小和 大脑皮质对正在进行的言语的反应潜伏期取决于胎龄和大脑 语音ABR。我们还假设，足月儿和早产儿的关系将是不同的。这个目标是 这是因为我们的语音响应测量相对于传统方法的一个主要优势：相同的数据 脑干听觉诱发电位也提供皮质反应。这项创新的研究将是第一个获得 发育中婴儿从脑干到大脑的自然、连续言语的听觉生理学测量 大脑皮层。这一高影响力的项目将推动对语言习得的新研究，并确定潜在的生物标志物 用于由于潜在的听觉处理缺陷而导致的沟通障碍。