Subcortical and Cortical Responses in Infants Evoked by Running Speech

婴儿跑步言语引起的皮质下和皮质反应

• 批准号: 10373228
• 负责人: Ross K Maddox
• 金额: $ 21.04万
• 依托单位: SYRACUSE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10373228
• 关键词: Acoustic Nerve; Acoustics; Address; Adult; Affect; Age; Auditory; Auditory Brainstem Responses; Auditory Evoked Potentials; Auditory area; Auditory system; Biological Markers; Brain Stem; Child; Clinical; Code; Communication; Communication impairment; Data; Development; Effectiveness; Event; Frequencies; Gestational Age; Goals; Hearing; Human Development; Infant; Interruption; Laboratories; Language; Language Delays; Language Development; Lateral lemniscus; Lead; Learning; Length; Life; Literature; Measurement; Measures; Methods; Midbrain structure; Nervous system structure; Newborn Infant; Pathway interactions; Performance; Physiological; Premature Infant; Process; Protocols documentation; Research; Response Latencies; Running; Scientific Inquiry; Signal Transduction; Social Interaction; Speech; Speech Perception; Stimulus; System; Techniques; Testing; Training; Validation; Voice; auditory processing; autism spectrum disorder; base; complement system; disability; experience; falls; innovation; insight; millisecond; myelination; neural network; neurodevelopment; novel; perinatal period; potential biomarker; relating to nervous system; response; sound; speech processing; tool

Efficient subcortical and cortical auditory processing is integral for learning spoken language. The goal of this project is to use a new tool we have developed to investigate responses to natural speech across the auditory hierarchy. Effective coding of the dynamic speech signal during development partially drives cortical development, and auditory neural deficits contribute to lifelong listening disabilities. While there are methods for measuring responses from the brainstem by the auditory brainstem response (ABR) and from the cortex (central auditory evoked potentials [CAEP]) in infants, only very short sounds can be used to evoke them which lack the complexity and richness of natural speech. Measurement of auditory responses to continuous, natural speech measured from the periphery through the brainstem and cortex opens the door for a broad spectrum of scientific inquiries including speech perception, language acquisition, and auditory processing deficits underlying various types of communication disorders. Despite the traditional stimulus limitations, the decrease in ABR and CAEP wave latencies and the increase in wave amplitudes with increasing infant age is used as a measure of maturation of brainstem myelination and cortical development for scientific and clinical purposes. Typically, only one or the other is measured, because they require different acquisition protocols. To address the limitations in non-natural stimuli and inability to measure brainstem and cortical responses simultaneously, the Maddox laboratory has pioneered a technique to measure the ABR and CAEP simultaneously to natural, running speech and shown its effectiveness in adults. In this project we will validate the technique in newborns and young infants, and define the relationship between brainstem and cortical responses over the first five months of life. In the first aim, we test the hypothesis that the novel speech ABR reflects auditory brainstem maturation. We hypothesize that the latencies of the response waves correlate with gestational age in term and preterm infants. We expect that there will be a relationship between click and speech ABR latencies, but that the developmental trajectory may be different, thereby providing new, complementary information. Based on previous literature, we also expect that trajectories will be different for term and preterm infants. In the second specific aim, we will characterize the cortical responses in infants and test the hypothesis that the size and latency of cortical responses to ongoing speech is dependent both on gestational age and wave latencies of the speech ABR. We also hypothesize that the relationships will be different for term and preterm infants. This aim is made possible by a major advantage of our speech response measure over traditional methods: the same data from which the ABR is derived also provides cortical responses. This innovative study will be the first to obtain auditory physiological measures of natural, running speech in developing infants from the brainstem to the cortex. This high-impact project will drive new studies of language acquisition and identify potential biomarkers for communication disorders due to underlying auditory processing deficiencies.

有效的皮层下和皮层听觉处理是学习口语不可或缺的。这个目标 项目是使用我们开发的一种新工具来研究听觉上对自然语音的反应。 等级制度。在发育过程中对动态语音信号的有效编码部分地驱动皮层 听觉神经缺陷导致终身听力残疾。虽然有一些方法 用于通过听觉脑干反应（ABR）测量来自脑干的反应和来自皮层的反应， （中央听觉诱发电位[CAEP]）在婴儿，只有很短的声音可以用来唤起他们， 缺乏自然语言的复杂性和丰富性。对连续、自然的听觉反应的测量 从外周到脑干和皮层的语言测量为广泛的 科学调查，包括言语感知、语言习得和听觉处理缺陷 各种沟通障碍的基础。尽管有传统的刺激限制， 在ABR和CAEP中，波幅随婴儿年龄的增加而增加， 用于科学和临床目的的脑干髓鞘形成和皮质发育成熟的测量。 通常，只测量其中一个，因为它们需要不同的采集协议。解决 非自然刺激的局限性和不能同时测量脑干和皮层反应， Maddox实验室已经开创了一种同时测量ABR和CAEP的技术， 并在成年人中显示了其有效性。在这个项目中，我们将在新生儿中验证该技术 和年幼的婴儿，并确定脑干和皮质反应之间的关系，在前五个 几个月的生命。在第一个目标中，我们验证了新的言语ABR反映听觉脑干的假设， 成熟我们假设反应波的潜伏期与足月妊娠的胎龄相关， 早产儿我们预期，点击和语音ABR潜伏期之间存在关系，但 发展轨迹可能不同，从而提供新的补充信息。基于 根据先前的文献，我们还预计足月儿和早产儿的轨迹将不同。在第二 具体的目的，我们将描述婴儿的皮质反应，并测试假设的大小和 皮层对正在进行的语言反应的潜伏期取决于胎龄和脑电波潜伏期。 语音ABR。我们还假设足月儿和早产儿的关系是不同的。该目的是 这是因为我们的语音反应测量方法比传统方法有一个主要优势：相同的数据 从其导出ABR也提供皮层反应。这项创新研究将首次获得 发育中婴儿从脑干到脑干的自然连续言语的听觉生理学测量 皮层这个高影响力的项目将推动语言习得的新研究，并确定潜在的生物标志物 因为潜在的听觉处理缺陷而导致的交流障碍