Subcortical and Cortical Responses in Infants Evoked by Running Speech

婴儿跑步言语引起的皮质下和皮质反应

• 批准号: 10598552
• 负责人: Ross K Maddox
• 金额: $ 22.99万
• 依托单位: SYRACUSE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598552
• 关键词: Acoustic Nerve; Acoustics; Address; Adult; Affect; Age; Auditory; Auditory Brainstem Responses; Auditory Evoked Potentials; Auditory area; Auditory system; Brain Stem; Child; Clinical; Code; Communication impairment; Data; Development; Effectiveness; Event; Frequencies; Gestational Age; Goals; Hearing; Human Development; Infant; Interruption; Laboratories; Language; Language Delays; Language Development; Lateral lemniscus; Lead; Learning; Length; Life; Literature; Measurement; Measures; Methods; Midbrain structure; Nervous System; Newborn Infant; Pathway interactions; Performance; Physiological; Premature Infant; Process; Protocols documentation; Qualifying; Research; Response Latencies; Running; Scientific Inquiry; Signal Transduction; Social Interaction; Speech; Speech Perception; Stimulus; System; Techniques; Testing; Training; Validation; Voice; auditory processing; autism spectrum disorder; biomarker identification; complement system; disability; experience; falls; innovation; insight; language impairment; millisecond; myelination; neural; neural network; neurodevelopment; novel; perinatal period; potential biomarker; response; sound; speech processing; tool

Efficient subcortical and cortical auditory processing is integral for learning spoken language. The goal of this project is to use a new tool we have developed to investigate responses to natural speech across the auditory hierarchy. Effective coding of the dynamic speech signal during development partially drives cortical development, and auditory neural deficits contribute to lifelong listening disabilities. While there are methods for measuring responses from the brainstem by the auditory brainstem response (ABR) and from the cortex (central auditory evoked potentials [CAEP]) in infants, only very short sounds can be used to evoke them which lack the complexity and richness of natural speech. Measurement of auditory responses to continuous, natural speech measured from the periphery through the brainstem and cortex opens the door for a broad spectrum of scientific inquiries including speech perception, language acquisition, and auditory processing deficits underlying various types of communication disorders. Despite the traditional stimulus limitations, the decrease in ABR and CAEP wave latencies and the increase in wave amplitudes with increasing infant age is used as a measure of maturation of brainstem myelination and cortical development for scientific and clinical purposes. Typically, only one or the other is measured, because they require different acquisition protocols. To address the limitations in non-natural stimuli and inability to measure brainstem and cortical responses simultaneously, the Maddox laboratory has pioneered a technique to measure the ABR and CAEP simultaneously to natural, running speech and shown its effectiveness in adults. In this project we will validate the technique in newborns and young infants, and define the relationship between brainstem and cortical responses over the first five months of life. In the first aim, we test the hypothesis that the novel speech ABR reflects auditory brainstem maturation. We hypothesize that the latencies of the response waves correlate with gestational age in term and preterm infants. We expect that there will be a relationship between click and speech ABR latencies, but that the developmental trajectory may be different, thereby providing new, complementary information. Based on previous literature, we also expect that trajectories will be different for term and preterm infants. In the second specific aim, we will characterize the cortical responses in infants and test the hypothesis that the size and latency of cortical responses to ongoing speech is dependent both on gestational age and wave latencies of the speech ABR. We also hypothesize that the relationships will be different for term and preterm infants. This aim is made possible by a major advantage of our speech response measure over traditional methods: the same data from which the ABR is derived also provides cortical responses. This innovative study will be the first to obtain auditory physiological measures of natural, running speech in developing infants from the brainstem to the cortex. This high-impact project will drive new studies of language acquisition and identify potential biomarkers for communication disorders due to underlying auditory processing deficiencies.

有效的皮质下和皮质听觉处理是学习口语不可或缺的。目标的目标 项目是使用我们开发的新工具来调查听觉上对自然语音的回应 等级制度。开发过程中动态语音信号的有效编码部分驱动皮质 发育和听觉神经缺陷有助于终生听力障碍。虽然有方法 通过听觉脑干反应（ABR）和皮层测量脑干的反应 （中央听觉引起的潜力[CAEP]）在婴儿中，只能使用非常短的声音来唤起它们 缺乏自然言语的复杂性和丰富性。对连续自然的听觉响应的测量 通过脑干和皮层从周围测量的语音为广阔的范围打开了大门 科学询问，包括语音感知，语言获取和听觉处理缺陷 各种类型的沟通障碍。尽管有传统的刺激限制，但减少 在ABR和CAEP波潜伏期中，随着婴儿年龄的增加，波幅度的增加被用作 用于科学和临床目的的脑干髓鞘和皮质发育的成熟度度量。 通常，仅测量一个或另一个，因为它们需要不同的采集协议。解决 非天然刺激的局限性以及无法同时测量脑干和皮质反应的局限性， Maddox实验室已经开创了一种技术，可以同时测量ABR并同时进行自然， 运行语音并显示出其在成人中的有效性。在这个项目中，我们将验证新生儿的技术 和年轻的婴儿，并在前五个中定义了脑干与皮质反应之间的关系 生命的月份。在第一个目标中，我们检验了新的语音ABR反映听觉脑干的假设 成熟。我们假设响应波的潜伏期与期限与胎龄相关 早产婴儿。我们希望点击和语音延迟之间会有关系，但是 发展轨迹可能有所不同，从而提供了新的补充信息。基于 以前的文献，我们还期望轨迹在学期和早产儿中会有所不同。在第二个 具体目的，我们将表征婴儿中皮质反应，并检验以下假设。 对正在进行语音的皮质反应的潜伏期取决于胎龄和波浪延迟 演讲abr。我们还假设，对于术语和早产儿，这种关系将有所不同。这个目标是 通过我们的语音响应措施比传统方法的主要优势，使其成为可能：相同的数据 从中得出ABR还提供皮质反应。这项创新的研究将是第一个获得的 自然的听觉生理措施，从脑干到发育的婴儿发言 皮质。这个高影响力的项目将推动语言获取的新研究，并确定潜在的生物标志物 对于基本的听觉处理缺陷而引起的沟通障碍。