BLRD Research Career Scientist Award Application

项目概要/摘要 本申请要求任命温迪·博拉格博士，查理大学的研究生理学家， 格鲁吉亚奥古斯塔的诺伍德退伍军人医疗中心和附属机构的生理学教授 （奥古斯塔大学），研究职业科学家的位置。在过去的五年里，Bollag博士一直在 富有成效，发表了29篇同行评议的文章和10多篇特邀评论，书籍章节和 评论，有52篇同行评议的文章和26篇特邀评论，书中的章节和评论 近10年Bollag博士在细胞信号方面的研究旨在了解特定信号的作用 分子在各种细胞过程中;这项研究导致了她感兴趣的系统的有趣发现， 皮肤表皮的角质形成细胞和肾上腺的肾小球细胞，以及这种细胞的延伸， 知识在其他系统的合作项目，包括角膜伤口愈合。在皮肤的情况下， 和肾上腺，Bollag博士感兴趣的是确定角质形成细胞的信号通路 在正常和病理条件下增殖和分化以形成表皮，以及那些 调节肾上腺球状体中醛固酮的产生。在过去的十年里，Bollag实验室 在研究这两个过程的项目中取得了重大进展，许多出版物证明了这一点。 她是这本书的资深作者Bollag博士还作为主要研究者（PI）或共同PI收到了三份 美国国立卫生研究院（NIH）R 01奖，一个R29奖和一个R21奖，五个VA优异奖（三个 一个用于支持她在皮肤方面的工作，一个用于资助肾上腺的研究，一个用于支持她在 角膜），VA研究职业科学家奖，两个VA共享设备评估计划（ShEEP） 奖励和多个国家和校内补助金奖励。她最近还收到了，作为联系共同PI，一个NIH T35培训奖（与共同PI，卡洛斯Isales博士）从三个波多黎各医疗机构招募医学生 学校进行夏季老龄化研究。她还曾担任多个奖项的联合调查员， 包括NIH P01计划项目奖与她的同事和合作者约35年，博士。 Isales，并担任国防部授予奥尔巴尼州的指导伙伴关系奖的首席指导员 大学去年，她获得了奥古斯塔大学研究所杰出研究者奖; 她还应邀在2019年实验生物学年会上作专题报告。这 今年，她应邀出席了2020年调查学会年会的空白论坛。 皮肤病学（由于大流行而不幸取消），并在 俄克拉荷马州神经科学中心（因COVID-19推迟至2021年），表明她是 因为她的研究而出名。最后，Bollag博士是一个与社区接触并参与其中的人。 在机构、地方和国家层面回馈社会。因此，她指导年轻的同事， 包括最近获得退伍军人事务部职业发展奖的Debra Irsik博士，为 附属机构（为此她获得了许多奖项），担任多家期刊的审稿人， 参加包括退伍军人事务部在内的几个国家和国际资助机构的审查小组。目前， 博士Bollag是《皮肤病学研究杂志》的编辑顾问，该杂志是美国影响力最大的杂志。 皮肤病学研究领域，内分泌学杂志和分子生物学杂志的高级编辑。 内分泌学和脂质研究和分子杂志编委会成员 药理学。因此，Bollag博士是一个既定的调查员和公认的导师，谁会熟练地履行 研究职业科学家的职责。

Project Summary/Abstract This application requests the appointment of Dr. Wendy Bollag, a Research Physiologist at the Charlie Norwood VA Medical Center in Augusta, Georgia and a Professor of Physiology at the affiliate institution (Augusta University), to the position of Research Career Scientist. In the past five years, Dr. Bollag has been productive, publishing 29 peer-reviewed articles and more than 10 invited reviews, book chapters and commentaries, with 52 peer-reviewed articles and 26 invited reviews, book chapters and commentaries in the past 10 years. Dr. Bollag’s research in cell signaling seeks to understand the role of particular signaling molecules in various cell processes; this research has led to interesting findings in her systems of interest, keratinocytes of the skin epidermis and zona glomerulosa cells of the adrenal gland, as well as extension of this knowledge to collaborative projects in other systems, including corneal wound healing. In the case of the skin and the adrenal gland, Dr. Bollag is interested in determining the signaling pathways that underlie keratinocyte proliferation and differentiation to form the epidermis under normal and pathological conditions, as well as those that regulate aldosterone production in the adrenal zona glomerulosa. In the past 10 years the Bollag laboratory has made significant progress in projects examining these two processes, as evidenced by the many publications for which she is the senior author. Dr. Bollag has also received as Principal Investigator (PI) or Co-PI three National Institutes of Health (NIH) R01 awards, one R29 award and one R21 award, five VA Merit Awards (three to support her work in skin, one to fund studies in the adrenal gland and one to support a new study in the cornea), a VA Research Career Scientist Award, two VA Shared Equipment Evaluation Program (ShEEP) awards and multiple state and intramural grant awards. She also recently received, as Contact Co-PI, an NIH T35 training award (with Co-PI, Dr. Carlos Isales) to recruit medical students from three Puerto Rican medical schools to perform summer aging research. She has also served as a Co-Investigator on several awards, including an NIH P01 Program Project Award with her colleague and collaborator of approximately 35 years, Dr. Isales, and as the Lead Mentor on a Department of Defense mentoring partnership award to Albany State University. Last year she received the Augusta University Research Institute Distinguished Investigator Award; she was also invited to give a symposium presentation at the 2019 annual meeting of Experimental Biology. This year she was invited to present in the Blank Forum at the 2020 annual meeting of the Society for Investigative Dermatology (which was unfortunately cancelled due to the pandemic) and to give a named lecture at the Oklahoma Center of Neuroscience (postponed until 2021 because of COVID-19), indicating that she is recognized for her research. Finally, Dr. Bollag is an individual who is engaged with the community and involved in giving back in service at the institutional, local and national levels. Thus, she mentors junior colleagues, including Dr. Debra Irsik, a recent VA Career Development Award recipient, provides educational service to the affiliate institution (for which she has received numerous awards), serves as a reviewer for multiple journals and participates in review panels for several national and international funding agencies, including the VA. Currently, Dr. Bollag is an Editorial Consultant for the Journal of Investigative Dermatology, the highest impact journal in the field of dermatology research, a Senior Editor for the Journal of Endocrinology and the Journal of Molecular Endocrinology and a member of the editorial boards of the Journal of Lipid Research and Molecular Pharmacology. Thus, Dr. Bollag is an established investigator and a recognized mentor, who would adeptly fulfill the responsibilities of the Research Career Scientist designation.