BLRD Research Career Scientist Award Application

项目摘要/摘要 本申请表要求任命查理学院的研究生理学家温迪·博拉格博士 佐治亚州奥古斯塔的诺伍德退伍德医学中心，附属机构的生理学教授 (奥古斯塔大学)，担任研究职业科学家。在过去的五年里，博拉格博士一直 富有成效，发表了29篇同行评议文章和10多篇特邀评论、书籍章节和 评论，有52篇同行评议文章和26篇受邀评论、书籍章节和评论 过去的10年里。博拉格博士在细胞信号方面的研究试图了解特定信号的作用 分子在不同的细胞过程中；这项研究在她感兴趣的系统中产生了有趣的发现， 皮肤表皮的角质形成细胞和肾上腺的肾小球带细胞及其延伸 了解其他系统中的协作项目，包括角膜伤口愈合。在皮肤的情况下 和肾上腺，博拉格博士感兴趣的是确定构成角质形成细胞的信号通路 在正常和病理条件下增殖和分化形成表皮，以及 调节肾上腺球状带中的醛固酮的产生。在过去的10年里，博拉格实验室 在审查这两个过程的项目方面取得了重大进展，许多出版物都证明了这一点 她是这本书的资深作者。博拉格博士还获得了首席调查员(PI)或联合PI三人 美国国立卫生研究院(NIH)R01奖，一项R29奖和一项R21奖，五项VA优秀奖(三项 为了支持她在皮肤方面的工作，一个是资助肾上腺的研究，另一个是支持在 眼角膜)、退伍军人研究职业科学家奖、两个退伍军人共享设备评估计划(SHEEP) 奖项和多个州和校内奖助金。作为联系人，她最近还收到了一名NIH T35培训奖(与共同派卡洛斯·伊萨莱斯博士)从三名波多黎各医学专业招收医学生 学校进行暑期老龄化研究。她还担任过几个奖项的联合调查员， 包括与她的同事和合作者一起获得NIH P01项目奖，她有大约35年的时间。 Isales，并担任国防部向奥尔巴尼州立大学颁发的指导伙伴奖的首席导师 大学。去年，她获得了奥古斯塔大学研究院杰出研究员奖； 她还应邀在2019年实验生物学年会上做专题演讲。这 那年，她应邀在空白论坛的2020年调查学会年会上发表演讲 皮肤科(由于大流行而不幸取消)，并在 俄克拉荷马神经科学中心(因新冠肺炎推迟到2021年)，表明她是 因她的研究而受到认可。最后，博拉格博士是一个与社区接触并参与其中的人 在机构、地方和国家各级回馈服务。因此，她指导初级同事， 包括最近获得退伍军人事务部职业发展奖的黛布拉·伊尔西克博士，为 附属机构(她因此获得了许多奖项)，担任多个期刊的审稿人，并 参加包括退伍军人事务部在内的几个国家和国际资助机构的审查小组。目前， 博拉格博士是《调查皮肤病学杂志》的编辑顾问，该杂志是全球影响力最大的杂志 皮肤科研究领域，《内分泌学杂志》和《分子》杂志高级编辑 他是《脂质研究和分子》杂志的内分泌学和编辑委员会成员 药理学。因此，博拉格博士是一位知名的研究人员和公认的导师，他将熟练地完成 研究职业科学家称号的责任。

Project Summary/Abstract This application requests the appointment of Dr. Wendy Bollag, a Research Physiologist at the Charlie Norwood VA Medical Center in Augusta, Georgia and a Professor of Physiology at the affiliate institution (Augusta University), to the position of Research Career Scientist. In the past five years, Dr. Bollag has been productive, publishing 29 peer-reviewed articles and more than 10 invited reviews, book chapters and commentaries, with 52 peer-reviewed articles and 26 invited reviews, book chapters and commentaries in the past 10 years. Dr. Bollag’s research in cell signaling seeks to understand the role of particular signaling molecules in various cell processes; this research has led to interesting findings in her systems of interest, keratinocytes of the skin epidermis and zona glomerulosa cells of the adrenal gland, as well as extension of this knowledge to collaborative projects in other systems, including corneal wound healing. In the case of the skin and the adrenal gland, Dr. Bollag is interested in determining the signaling pathways that underlie keratinocyte proliferation and differentiation to form the epidermis under normal and pathological conditions, as well as those that regulate aldosterone production in the adrenal zona glomerulosa. In the past 10 years the Bollag laboratory has made significant progress in projects examining these two processes, as evidenced by the many publications for which she is the senior author. Dr. Bollag has also received as Principal Investigator (PI) or Co-PI three National Institutes of Health (NIH) R01 awards, one R29 award and one R21 award, five VA Merit Awards (three to support her work in skin, one to fund studies in the adrenal gland and one to support a new study in the cornea), a VA Research Career Scientist Award, two VA Shared Equipment Evaluation Program (ShEEP) awards and multiple state and intramural grant awards. She also recently received, as Contact Co-PI, an NIH T35 training award (with Co-PI, Dr. Carlos Isales) to recruit medical students from three Puerto Rican medical schools to perform summer aging research. She has also served as a Co-Investigator on several awards, including an NIH P01 Program Project Award with her colleague and collaborator of approximately 35 years, Dr. Isales, and as the Lead Mentor on a Department of Defense mentoring partnership award to Albany State University. Last year she received the Augusta University Research Institute Distinguished Investigator Award; she was also invited to give a symposium presentation at the 2019 annual meeting of Experimental Biology. This year she was invited to present in the Blank Forum at the 2020 annual meeting of the Society for Investigative Dermatology (which was unfortunately cancelled due to the pandemic) and to give a named lecture at the Oklahoma Center of Neuroscience (postponed until 2021 because of COVID-19), indicating that she is recognized for her research. Finally, Dr. Bollag is an individual who is engaged with the community and involved in giving back in service at the institutional, local and national levels. Thus, she mentors junior colleagues, including Dr. Debra Irsik, a recent VA Career Development Award recipient, provides educational service to the affiliate institution (for which she has received numerous awards), serves as a reviewer for multiple journals and participates in review panels for several national and international funding agencies, including the VA. Currently, Dr. Bollag is an Editorial Consultant for the Journal of Investigative Dermatology, the highest impact journal in the field of dermatology research, a Senior Editor for the Journal of Endocrinology and the Journal of Molecular Endocrinology and a member of the editorial boards of the Journal of Lipid Research and Molecular Pharmacology. Thus, Dr. Bollag is an established investigator and a recognized mentor, who would adeptly fulfill the responsibilities of the Research Career Scientist designation.