BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

基本信息

  • 批准号:
    10373036
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-04-01 至 2026-03-31
  • 项目状态:
    未结题

项目摘要

Sleep loss and sleep disorders (e.g., sleep apnea) lead to excessive daytime sleepiness and impaired attention & cognition. The symptoms of sleep disturbance are now recognized as major contributors to accident rates and decreased workplace productivity. Attention, concentration, and cognitive problems are also a major feature of other disorders that are prevalent in US veterans – e.g., TBI, PTSD, Alzheimer's disease, depression, substance use disorder, and schizophrenia. Understanding the brain circuitry controlling attention will guide the development of treatments to ameliorate cognitive impairments of these conditions. Abundant evidence indicates that the basal forebrain (BF) region contains cortically projecting & wakefulness promoting neurons that are important for cortical activation, behavioral arousal/alertness, and attention. Although previous work has focused on the role of BF cholinergic neurons in attention, advances in optogenetic methods allow the investigation of BF parvalbumin (PV) containing GABAergic neurons. Work on my current Merit grant indicates that selective excitation of BF PV neurons in mice produces cortical activation, wakefulness, and behavioral arousal. Our new data show that excitation of BF PV neurons enhances vigilant attention to rescue reaction time deficits produced by sleep loss and also enhances attention-dependent associative learning without affecting motivation (i.e. hunger, a potential side effect) or reward (i.e. abuse potential). Our overarching hypothesis to explain these findings is that BF PV neurons mediate rapid changes in alertness/attention by quickly activating the cortex in anticipation of, or in response to, meaningful or surprising sensory stimuli. Research methods used to evaluate this hypothesis include i) fiber photometry to measure the activity of BF PV neurons, and, ii) optogenetic methods to either excite or inhibit these neurons in mice; both approaches are combined with behavioral tests and measures of cortical electrical activity. The translational relevance of this basic science project is that BF PV excitation may be used to enhance cognition with limited side effects and low abuse potential. The overarching goal of this research program is to understand the mechanisms of basal forebrain regulation of cortical activity and cognition which could lead to treatments for a variety of disorders that impact US Veterans. For example, the pro-cognitive properties of the BF PV model described above can be readily applied to additional mouse models of diseases that are prevalent in the US Veteran population including Alzheimer’s disease (AD) and traumatic brain injury (TBI). Indeed, other ongoing studies with research fellow (Dr. Felipe Schiffino) and collaborators (Drs. Jay McNally & Lee Goldstein) are testing BF PV excitation benefits in mouse models of AD and TBI. 1
睡眠不足和睡眠障碍(如睡眠呼吸暂停)导致白天过度嗜睡和受损

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

ROBERT E STRECKER其他文献

ROBERT E STRECKER的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('ROBERT E STRECKER', 18)}}的其他基金

BLRD Research Career Scientist Award Application
BLRD 研究职业科学家奖申请
  • 批准号:
    10618193
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Role of the basal forebrain in sleep loss induced attention impairments
基底前脑在睡眠不足引起的注意力障碍中的作用
  • 批准号:
    10620170
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Sleep loss impairment of arousal and cognition: role of the basal forebrain
睡眠不足对觉醒和认知的损害:基底前脑的作用
  • 批准号:
    8921583
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Sleep loss impairment of arousal and cognition: role of the basal forebrain
睡眠不足对觉醒和认知的损害:基底前脑的作用
  • 批准号:
    9206087
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Role of the basal forebrain in sleep loss induced attention impairments
基底前脑在睡眠不足引起的注意力障碍中的作用
  • 批准号:
    10359072
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Adenosine and the Basal Forebrain in the Control of Behavioral State
腺苷和基底前脑控制行为状态
  • 批准号:
    7786264
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
Adenosine and the Basal Forebrain in the Control of Behavioral State
腺苷和基底前脑控制行为状态
  • 批准号:
    7687191
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
Adenosine and the Basal Forebrain in the Control of Behavioral State
腺苷和基底前脑控制行为状态
  • 批准号:
    8195550
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
Adenosine and the Basal Forebrain in the Control of Behavioral State
腺苷和基底前脑控制行为状态
  • 批准号:
    8258633
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
DOPAMINE RELEASE INDUCED BY 4-METHYLAMINOREX
4-METHYLAMINOREX 诱导的多巴胺释放
  • 批准号:
    2119972
  • 财政年份:
    1991
  • 资助金额:
    --
  • 项目类别:

相似国自然基金

细胞外腺苷(Adenosine)作为干细胞旁分泌因子的生物学鉴定和功能分析
  • 批准号:
    81570244
  • 批准年份:
    2015
  • 资助金额:
    57.0 万元
  • 项目类别:
    面上项目
Adenosine诱导A1/A2AR稳态失衡启动慢性低灌注白质炎性损伤及其机制
  • 批准号:
    81171113
  • 批准年份:
    2011
  • 资助金额:
    55.0 万元
  • 项目类别:
    面上项目

相似海外基金

Targeting the A2B Adenosine Receptor for Immunoprevention of Pancreatic Cancer
靶向 A2B 腺苷受体用于胰腺癌的免疫预防
  • 批准号:
    10929664
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Exploring the role of adenosine A2A receptors in Schizophrenia using opto-pharmacologically controlled allosteric modulation.
利用光药理学控制的变构调节探索腺苷 A2A 受体在精神分裂症中的作用。
  • 批准号:
    23K14685
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
The Role of Adenosine Kinase in Mixed Diastolic Heart Failure and Alzheimer Disease
腺苷激酶在混合性舒张性心力衰竭和阿尔茨海默病中的作用
  • 批准号:
    10679989
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Allostery-driven G protein selectivity in the adenosine A1 receptor
腺苷 A1 受体中变构驱动的 G 蛋白选择性
  • 批准号:
    BB/W016974/1
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Investigation of new test methods for adenosine-sensitive atrioventricular block
腺苷敏感型房室传导阻滞新检测方法的探讨
  • 批准号:
    23K07566
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Probing the role of adenosine pathway in SIV pathogenesis
探讨腺苷途径在 SIV 发病机制中的作用
  • 批准号:
    10760676
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
The role of A1 adenosine receptor signaling in the decline of S. pneumoniae killing by neutrophils in vaccinated aged hosts
A1 腺苷受体信号传导在疫苗接种老年宿主中中性粒细胞杀伤肺炎链球菌下降中的作用
  • 批准号:
    10605737
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Adenosine triphosphate as a master variable for biomass in the oceanographic context
三磷酸腺苷作为海洋学背景下生物量的主变量
  • 批准号:
    2319114
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
The Biology of Microglia: Adenosine A3 Receptor Suppression
小胶质细胞的生物学:腺苷 A3 受体抑制
  • 批准号:
    RGPIN-2019-06289
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Discovery Grants Program - Individual
Postnatal development of adenosine kinase in the brainstem network that controls breathing
控制呼吸的脑干网络中腺苷激酶的出生后发育
  • 批准号:
    573323-2022
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    University Undergraduate Student Research Awards
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了