Shared Pathophysiology of Postoperative Delirium and Alzheimer's Disease and Related Dementias
Shared Pathophysiology of Postoperative Delirium and Alzheimer's Disease and Related Dementias
批准号:
10374052
负责人:
SARINNAPHA VASUNILASHORN
金额:
$11.69万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-07-15 至 2024-03-31
关键词:
AcuteAddressAdultAgeAgingAllelesAlzheimer&aposs disease related dementiaApolipoprotein EAreaBiological MarkersBlood - brain barrier anatomyBrainC-reactive proteinCHI3L1 geneCerebrospinal FluidChitinaseClinicalCognitionCompetenceConfusionConsensusData AnalysesData CollectionData ReportingDeliriumDementiaElderlyEnrollmentEpidemiologyFoundationsFunctional disorderFundingGeneticGenetic MarkersGenetic Predisposition to DiseaseGenetic RiskGenotypeGlial Fibrillary Acidic ProteinGoalsHospitalsImpaired cognitionIncidenceIndividualInfectionInflammationInflammatoryInterleukin-6JointsK-Series Research Career ProgramsKnowledgeLightLinkMeasuresMentored Research Scientist Development AwardMethodsMicrogliaModelingNeurocognitiveNeurologic DysfunctionsNeuronal InjuryOperative Surgical ProceduresOrthopedicsPathway interactionsPatientsPeripheralPlasmaPlasma ProteinsPopulationPositioning AttributePredisposing FactorProteinsProtocols documentationQuality of lifeResearchResearch PersonnelResearch Project GrantsResourcesRiskRisk FactorsRisk MarkerSamplingSeriesSeveritiesSyndromeTimeTrainingTraining SupportUnited States National Institutes of HealthWorkWritingacute stressapolipoprotein E-4basebiobankbiological adaptation to stresscareercareer developmentcognitive functioncohortcostexperienceinflammatory markerinnovationknowledge baseneurofilamentneuroinflammationneuron lossneuroprotectionnovelnovel markerolder patientpatient orientedpostoperative deliriumpostoperative recoverypreventprogramsprotein biomarkersrisk predictionsecondary analysisskill acquisitionsystemic inflammatory responsetargeted treatmenttranslational scientist
中文摘要
项目总结/文摘
英文摘要
PROJECT SUMMARY/ABSTRACT
This K01 Career Development Award will support the training and career development of a junior investigator,
Dr. Sarinnapha Vasunilashorn, in patient-oriented aging research. The overall goal of the proposal is to provide
Dr. Vasunilashorn with critical skills and development of experience and competence as an independent,
translational researcher in delirium and Alzheimer's Disease and Related Dementias (ADRD). Specific training
goals include: 1) obtaining experience in primary data collection within a clinical setting, 2) expansion of her
analytic skillset in advanced longitudinal methods and genetic data analysis, and 3) building an in-depth
knowledge base of ADRD. These training goals will be conducted in coordination with a set of specific
research projects based on Dr. Vasunilashorn's preliminary data that reports on the association between
plasma inflammatory markers and the incidence and severity of postoperative delirium in older patients without
ADRD undergoing non-cardiac surgery. Delirium and ADRD have strong epidemiological associations: ADRD
has long-been recognized as a risk factor for delirium, and recently delirium has been implicated as a risk
factor for incident ADRD. Although this points to a clear link between delirium and ADRD, the shared
pathophysiology underlying these relationships remains largely unknown. In the proposed K01 Specific Aims,
Dr. Vasunilashorn will address this gap in knowledge and substantially extend her preliminary studies that have
focused only on plasma-based markers of inflammation by examining whether both plasma and cerebrospinal
fluid (CSF)-based measures of neuroinflammation and neuronal injury are associated with postoperative
delirium, long-term cognitive decline, and incident ADRD, and evaluate whether genetic risk modifies these
associations. These studies will leverage the considerable resources of: 1) the NIA-funded program project,
the Successful Aging after Elective Surgery Study (SAGES; P01AG031720), and 2) the Healthier
Postoperative Recovery Study (HiPOR; R21AG048600). This proposal is highly novel in examining markers of
neuroinflamamtion and neuronal injury that will advance our understanding of the pathophysiologic
mechanisms underlying the delirium-ADRD relationship, a largely underexplored area that represents a top
priority area of the NIH (PAR-17-038). Importantly, the results will inform pathophysiologically targeted
treatment for inflammation to provide neuroprotection and identify important variables to refine delirium risk
prediction strategies thereby potentially preventing delirium and reducing ADRD. Ultimately, this work will pave
the way and provide the foundation for the launch of Dr. Vasunilashorn's independent research career that will
explore the pathophysiologic linkages of delirium and ADRD, two major threats to the independence and
quality of life of all older adults.
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DOI:
10.1111/jgs.18677
发表时间:
2023-11
期刊:
Journal of the American Geriatrics Society
影响因子:
6.3
作者:
[S. Deiner;Edward R. Marcantonio;Shrunjal Trivedi;S. Inouye;Thomas G. Travison;E. Schmitt;Tammy Hshieh;T. Fong;Long H. Ngo;S. Vasunilashorn]
通讯作者:
S. Deiner;Edward R. Marcantonio;Shrunjal Trivedi;S. Inouye;Thomas G. Travison;E. Schmitt;Tammy Hshieh;T. Fong;Long H. Ngo;S. Vasunilashorn
DOI:
10.1016/j.jagp.2018.09.007
发表时间:
2019-01
期刊:
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
影响因子:
--
作者:
[Vasunilashorn SM, Ngo LH, Jones RN, Inouye SK, Hall KT, Gallagher J, Dillon ST, Xie Z, Libermann TA, Marcantonio ER]
通讯作者:
Marcantonio ER
The association of urine osmolality with decreased kidney function and/or albuminuria in the United States.
在美国,尿液渗透压与肾功能和/或蛋白尿的降低。
DOI:
10.1186/s12882-021-02478-9
发表时间:
2021-09-10
期刊:
BMC nephrology
影响因子:
2.3
作者:
[Kitiwan BK, Vasunilashorn SM, Baer HJ, Mukamal K, Juraschek SP]
通讯作者:
Juraschek SP
DOI:
10.1002/alz.12941
发表时间:
2023-05
期刊:
ALZHEIMERS & DEMENTIA
影响因子:
14
作者:
[Vasunilashorn, Sarinnapha M., Lunardi, Nadia, Newman, John C., Crosby, Gregory, Acker, Leah, Abel, Ted, Bhatnagar, Seema, Cunningham, Colm, de Cabo, Rafael, Dugan, Laura, Hippensteel, Joseph A., Ishizawa, Yumiko, Lahiri, Shouri, Marcantonio, Edward R., Xie, Zhongcong, Inouye, Sharon K., Terrando, Niccolo, Eckenhoff, Roderic G.]
通讯作者:
Eckenhoff, Roderic G.
DOI:
10.1159/000533789
发表时间:
2023
期刊:
Gerontology
影响因子:
3.5
作者:
[]
通讯作者:
共 10 条
Brain Vulnerability in Delirium and Alzheimer’s Disease and Related Dementias: Intersection of Polygenic Risk and Inflammation
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批准号:10559987
-
项目类别:
-
资助金额:$88.67万
-
财政年份:2023
-
负责人:SARINNAPHA VASUNILASHORN
-
依托单位:
Shared Pathophysiology of Postoperative Delirium and Alzheimer's Disease and Related Dementias
-
批准号:9902270
-
项目类别:
-
资助金额:$11.32万
-
财政年份:2018
-
负责人:SARINNAPHA VASUNILASHORN
-
依托单位:
海外基金