Scalable Synthesis and New Bond Disconnections
可扩展的合成和新的键断裂
基本信息
- 批准号:10373114
- 负责人:
- 金额:$ 109.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdoptionAlkaloidsArchitectureBiochemical PathwayBiologicalBiomedical ResearchBreathingChemicalsCollaborationsComplexDevelopmentDrug IndustryEnvironmentFDA approvedFamilyFolk MedicineHuman bodyIndustrializationKnowledgeLaboratoriesLiteratureMediator of activation proteinMethodologyMethodsModernizationNatural ProductsNatureOrganic ChemistryPharmaceutical ChemistryPharmaceutical PreparationsPharmacologic SubstanceProceduresPropertyReagentResearchScientistSourceSynthesis ChemistryTerpenesTranscendcostdrug discoveryfield studyinterestnovelprogramsscaffoldsuccess
项目摘要
PROJECT SUMMARY/ABSTRACT
Natural products have long held societal value as folk medicines, and even in this modern era,
many FDA-approved drugs are still being derived from terpenes and alkaloids found in nature.
Biomedical research has also benefited from natural products, as previously unknown
mechanisms of action have been discovered while studying the unique biochemical pathways
that these compounds undergo in the human body. Furthermore, endeavors in the total synthesis
of these architecturally diverse compounds have continuously provided chemists with challenges,
which in turn have led to the establishment of research programs in both academic and industrial
environments. Ever since its inception, our laboratory has been pursuing, and has succeeded in,
the total synthesis of iconic natural products in both the terpene and alkaloid families. These
syntheses have identified gaps in the chemical literature, which we have subsequently addressed.
The products of this research program—new synthetic strategies, unprecedented transformations
and novel reagents—have in turn enabled the synthesis of even more natural products and
pharmaceutically relevant motifs, thus completing a catalytic cycle of discovery. We seek to
replicate this success with the current proposal: the described projects will target complex natural
products to identify shortcomings in chemical methodology, while simultaneously devising
methods of widespread interest, followed by the assessment of their practicality in the synthesis
of complex molecules. For the next five years our laboratory will generate chemical knowledge
that transcends the original objective of natural product synthesis. We will focus on efficiently
synthesize complex natural products aiming for ideality. We will also develop of useful methods
for synthesis and medicinal chemistry. The resulting procedures will be utilized in the construction
of complex pharmaceutical motifs, which will serve to expand chemical space and accelerate
discovery in drug discovery. Notably, we have already established numerous collaborations to
study the biological properties of the products that will be synthesized, to validate and field-test
new methods, and to commercialize reagents for widespread adoption in both academic and
industrial settings. Lastly, we will focus on strategic applications and development of synthetic
organic electrochemical methods, wherein the development of oxidative mediators for C-H
functionalization, desaturation of carbonyls, and reductive cross-couplings are presented.
项目总结/文摘
项目成果
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{{ truncateString('PHIL S BARAN', 18)}}的其他基金
Scalable Synthesis and New Bond Disconnections
可扩展的合成和新的键断裂
- 批准号:
10580740 - 财政年份:2016
- 资助金额:
$ 109.42万 - 项目类别:
Scalable Synthesis and New Bond Disconnections
可扩展的合成和新的键断裂
- 批准号:
10164654 - 财政年份:2016
- 资助金额:
$ 109.42万 - 项目类别:
Transcriptional silencing of latent HIV infection - a novel small molecule class
潜伏 HIV 感染的转录沉默——一类新型小分子
- 批准号:
8731293 - 财政年份:2014
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$ 109.42万 - 项目类别:
Preparative Radical Chemistry for Biomedical Research
生物医学研究的制备自由基化学
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8996063 - 财政年份:2013
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$ 109.42万 - 项目类别:
Preparative Radical Chemistry for Biomedical Research
生物医学研究的制备自由基化学
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8795737 - 财政年份:2013
- 资助金额:
$ 109.42万 - 项目类别:
Preparative Radical Chemistry for Biomedical Research
生物医学研究的制备自由基化学
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8485337 - 财政年份:2013
- 资助金额:
$ 109.42万 - 项目类别:
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