Preparative Radical Chemistry for Biomedical Research
生物医学研究的制备自由基化学
基本信息
- 批准号:8996063
- 负责人:
- 金额:$ 51.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-04-01 至 2017-01-31
- 项目状态:已结题
- 来源:
- 关键词:AirAlkylationAreaBiologicalBiomedical ResearchChemicalsChemistryCouplingDevelopmentDisadvantagedDisciplineFoodHalogensHealthHeterocyclic CompoundsHumanHydrogenKineticsLifeMalignant NeoplasmsMediatingMedicineMetalsMethodologyMethodsNitrogenOne-Step dentin bonding systemOrganismPharmaceutical ChemistryPharmacologic SubstanceProceduresPropertyReactionReagentResearchSaltsScienceSeriesSkeletonSocietiesSolubilitySolventsTechnologyTemperatureTherapeuticTimeTransition ElementsWaterZincalkyl groupappendageaqueousbasecatalystcostcryogenicsfightingfunctional groupimprovedinsightinterestprocess optimizationprogramssmall moleculetrenduser-friendly
项目摘要
DESCRIPTION (provided by applicant): Arenes and heteroarenes form the basis of living organisms and, as a consequence, are ubiquitous in pharmaceuticals and other biologically active compounds. Although there has been sustained interest in (hetero)arene functionalization, ever-growing time and cost constraints of discovery chemistry still demand the development of rapid, efficient and operationally trivial procedures. As this presents an immense task, this proposal will focus on the appendage of fluoroalkyl and alkyl groups onto (hetero)arenes (i.e., C-H to C-C transformations). Many methods are currently available for (hetero)arene functionalization, each of them presenting advantages and disadvantages. Although "programmed" C-C bond formations such as halogen-metal exchange/electrophilic trap, nucleophilic aromatic substitution and cross-coupling methodology are vital in all aspects of chemistry, these methods require the use of pre-functionalized (typically halogenated) (hetero)arenes, thus adding extra steps to the synthesis. In this regard, one-step methods are more attractive, however, hydrogen-metal exchange/electrophilic trap, electrophilic aromatic substitution and C-H activation methodology all present drawbacks as well, such as the use of highly acidic/basic reagents, cryogenic conditions, or expensive transition metal catalysts. These drawbacks can be potentially overcome by using a radical-based functionalization strategy: recent results have shown that zinc bis(difluoromethanesulfinate) can generate difluoromethyl radicals, which can add to a variety of heterocycles at room temperature under open air. Building upon these results, this proposal aims to generate a series of user-friendly, shelf-stable zinc bis(alkanesulfinate) reagents. These reagents will be made widely accessible and their reactions will be optimized from the vantage point of operational simplicity. This proposal is organized into three parts: 1) the first section details the synthesis of zinc bis(fluoroalkanesulfinate) reagents for direct (hetero)arene fluoroalkylation; 2) the second part outlines the development of zinc bis(alkanesulfinate) reagents for (hetero)arene alkylation, as well as the bis- functionalization of hetero(arene)s using a sequential addition strategy; and 3) the final section describes kinetic analysis to guide the optimization process and to elucidate solvent effects on regioselectivity. While these three objectives will be investigated in parallel,
they will all contribute in establishing reactivity trends of zinc bis(alkanesulfinate) reagents. Generating an armamentarium of these stable reagents and user- friendly procedures would accelerate discovery in medicinal chemistry, food chemistry, agrochemistry, and other chemical and scientific disciplines.
描述(由申请人提供):芳烃和杂芳烃构成活生物体的基础,因此在药物和其他生物活性化合物中普遍存在。尽管对(杂)芳烃官能化一直有兴趣,但发现化学的不断增长的时间和成本限制仍然需要开发快速、有效和操作简单的程序。由于这提出了一个巨大的任务,该建议将集中在氟烷基和烷基基团附加到(杂)芳烃上(即,C-H到C-C转化)。 目前有许多方法可用于(杂)芳烃官能化,它们中的每一种都呈现出优点和缺点。虽然“程序化”C-C键形成,如卤素-金属交换/亲电阱、亲核芳族取代和交叉偶联方法在化学的所有方面都是至关重要的,但这些方法需要使用预官能化(通常是卤化的)(杂)芳烃,从而为合成增加了额外的步骤。在这方面,一步法更有吸引力,然而,氢-金属交换/亲电捕集、亲电芳族取代和C-H活化方法也都存在缺点,例如使用高酸性/碱性试剂、低温条件或昂贵的过渡金属催化剂。这些缺点可以通过使用基于自由基的官能化策略来克服:最近的结果表明,双(二氟甲烷亚磺酸)锌可以产生二氟甲基自由基,其可以在室温下在露天下添加到各种杂环中。在这些结果的基础上,该提议旨在产生一系列用户友好的、储存稳定的双(烷亚磺酸)锌试剂。这些试剂将广泛使用,其反应将从操作简单的Vantage进行优化。 本论文分为三个部分:1)第一部分详细介绍了双锌的合成(2)第二部分概述了双(氟代)烷基亚磺酸锌的研究进展;用于(杂)芳烃烷基化的(烷基亚磺酸酯)试剂,以及使用顺序加成策略的杂(芳烃)的双官能化;最后一节描述了动力学分析,以指导优化过程并阐明溶剂对区域选择性的影响。虽然这三个目标将同时进行研究,
它们都将有助于建立双(链烷亚磺酸)锌试剂的反应性趋势。产生这些稳定试剂和用户友好程序的设备将加速药物化学、食品化学、农业化学和其他化学和科学学科的发现。
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Bioconjugation by native chemical tagging of C-H bonds.
- DOI:10.1021/ja407739y
- 发表时间:2013-09-04
- 期刊:
- 影响因子:15
- 作者:Zhou Q;Gui J;Pan CM;Albone E;Cheng X;Suh EM;Grasso L;Ishihara Y;Baran PS
- 通讯作者:Baran PS
A simple litmus test for aldehyde oxidase metabolism of heteroarenes.
- DOI:10.1021/jm4017976
- 发表时间:2014-02-27
- 期刊:
- 影响因子:7.3
- 作者:O'Hara F;Burns AC;Collins MR;Dalvie D;Ornelas MA;Vaz AD;Fujiwara Y;Baran PS
- 通讯作者:Baran PS
Simple sulfinate synthesis enables C-H trifluoromethylcyclopropanation.
- DOI:10.1002/anie.201406622
- 发表时间:2014-09-08
- 期刊:
- 影响因子:16.6
- 作者:Gianatassio, Ryan;Kawamura, Shuhei;Eprile, Cecil L.;Foo, Klement;Ge, Jason;Burns, Aaron C.;Collins, Michael R.;Baran, Phil S.
- 通讯作者:Baran, Phil S.
Radical C-H functionalization of heteroarenes under electrochemical control.
- DOI:10.1002/anie.201407948
- 发表时间:2014-10-27
- 期刊:
- 影响因子:16.6
- 作者:O'Brien, Alexander G.;Maruyama, Akinobu;Inokuma, Yasuhide;Fujita, Makoto;Baran, Phil S.;Blackmond, Donna G.
- 通讯作者:Blackmond, Donna G.
Mechanistic Insights into Two-Phase Radical C-H Arylations.
- DOI:10.1021/acscentsci.5b00332
- 发表时间:2015-11-25
- 期刊:
- 影响因子:18.2
- 作者:Baxter RD;Liang Y;Hong X;Brown TA;Zare RN;Houk KN;Baran PS;Blackmond DG
- 通讯作者:Blackmond DG
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PHIL S BARAN其他文献
PHIL S BARAN的其他文献
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{{ truncateString('PHIL S BARAN', 18)}}的其他基金
Transcriptional silencing of latent HIV infection - a novel small molecule class
潜伏 HIV 感染的转录沉默——一类新型小分子
- 批准号:
8731293 - 财政年份:2014
- 资助金额:
$ 51.73万 - 项目类别:
Preparative Radical Chemistry for Biomedical Research
生物医学研究的制备自由基化学
- 批准号:
8795737 - 财政年份:2013
- 资助金额:
$ 51.73万 - 项目类别:
Preparative Radical Chemistry for Biomedical Research
生物医学研究的制备自由基化学
- 批准号:
8485337 - 财政年份:2013
- 资助金额:
$ 51.73万 - 项目类别:
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