University of Washington Developmental AIDS Research Center for Mental Health (UW ARCH)

总体摘要 拟议中的华盛顿大学（UW）发展艾滋病研究中心（D-ARC）响应了 全球艾滋病疫情处于关键阶段。尽管全世界有2100多万人接受抗逆转录病毒治疗， 治疗，最边缘化的人群继续经历高发病率，更少获得有效的 预防和护理，以及更高的死亡率。在高流行率国家以及 美国的“地理热点”，如西雅图的金县。交叉的耻辱，创伤，贫困， 药物滥用增加了精神疾病的风险，但现有的有效治疗方法很少得到实施。 拟议中的D-ARC旨在通过促进有助于结束贫困的研究来应对这些挑战。 重点是将精神障碍护理纳入艾滋病毒预防和治疗 战略布局此外，中心研究人员将支持和应用传播科学， 执行，总体目标是使这些干预措施规模化。D-ARC旨在填补一个空白 在艾滋病毒行为科学研究在华盛顿大学的艾滋病毒专业知识的相当大的优势， 并将其与UW在开发和交付综合模型方面的长期领导地位联系起来 心理健康护理通过结合华盛顿大学在（a）艾滋病毒研究和（B）精神卫生保健方面的专业知识--现在是孤立的 从地理上、计划上和概念上，该中心将成为一个能够实现以下目标的协同力量： 是实施创新有效综合干预的使命。拟议的基础设施资本化 本地专业知识的优势和与全球合作网络的广泛联系，通过以下方式为UW增加价值 该中心的行政管理，研究支持和培训任务，通过额外的机构支持， 762，296美元的承诺。D-ARC的跨领域主题是：（a）利用地方和全球双向 （b）通过让供应商社区参与，为学习和创新开辟途径;（B）通过以下方式解决不平等问题： 测试减少差异的研究解决方案。四个拟议核心涉及总体具体目标： 促进和支持创新和有影响力的研究，以遏制艾滋病毒的流行，重点是综合 干预战略（行政核心）; 2）提供所需的技术援助和研究培训 与心理健康和艾滋病研究相关的设计、测量、理论和新的统计方法（方法 3）鼓励基于实践的研究，促进艾滋病毒方面有效的综合心理健康服务 护理环境和广泛传播研究结果（综合护理核心）;以及4）培养下一代 通过对早期研究人员的培训和创新指导， 发展核心（Developmental Core）

OVERALL ABSTRACT The proposed University of Washington (UW) Developmental AIDS Research Center (D-ARC) responds to the global HIV epidemic at a critical stage. Though more than 21 million people around the world receive antiretroviral therapy, the most marginalized populations continue to experience high incidence, less access to effective prevention and care, and greater mortality. Unmet needs persist in high-prevalence countries as well as “geographic hotspots” in the US such as Seattle's King County. Intersecting stigma, trauma, poverty, and substance abuse increase risk for mental illnesses, yet the effective treatments available are rarely implemented. The proposed D-ARC aims to address these challenges by catalyzing research that helps end the epidemic, with a focus on integrating care for mental disorders into HIV prevention and treatment strategies. Furthermore, Center investigators will support and apply the science of dissemination and implementation, with the overall goal of bringing such interventions to scale. The D-ARC aims to fill a gap in HIV behavioral science research at UW by capitalizing on the considerable strengths of UW's HIV expertise and bridging this with UW's longstanding leadership in the development and delivery of models of integrated mental health care. By combining UW expertise in (a) HIV research and (b) mental health care—now siloed geographically, programmatically, and conceptually—the Center will be a synergistic force capable of realizing is mission of Implementing Innovative Impactful Integrated Interventions. The proposed infrastructure capitalizes on the strengths of local expertise and broad ties with global collaborative networks, adding value to UW through the Center's administration, research support, and training missions, buttressed through additional institutional commitments of $762,296. Cross-cutting themes of the D-ARC are (a) leveraging local and global bidirectional pathways to learning and innovation by engaging communities of providers and (b) addressing inequities by testing research solutions that reduce disparities. Four proposed Cores address the Overall specific aims: 1) Catalyze and support innovative and impactful research to curb the HIV epidemic, with a focus on integrated intervention strategies (Administrative Core); 2) Provide needed technical assistance and training on research design, measurement, theory and novel statistical methods relevant to mental health and HIV research (Methods Core); 3) Stimulate practice-based research that promotes effective integrated mental health services in HIV care settings and disseminate findings broadly (Integrated Care Core); and 4) Nurture the Next Generation of diverse, multidisciplinary HIV researchers through training and innovative mentorship of early stage investigators and mentors (Developmental Core).