University of Washington Developmental AIDS Research Center for Mental Health (UW ARCH)

华盛顿大学心理健康发展艾滋病研究中心 (UW ARCH)

• 批准号: 10260314
• 负责人: Jane M. Simoni
• 金额: $ 74.97万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10260314
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Behavioral Sciences; Caring; Clinical; Communities; Complex; Consultations; Country; County; Development; Discrimination; Disease Management; Dissemination and Implementation; Epidemic; Epidemiology; Geography; Goals; HIV; HIV risk; Healthcare; High Prevalence; Incidence; Infrastructure; Intervention; Leadership; Learning; Measurement; Medical; Mental Depression; Mental Health; Mental Health Services; Mental disorders; Mentors; Mentorship; Methods; Mission; Modeling; Pathway interactions; Patients; Poverty; Practice based research; Prevention; Prevention strategy; Primary Health Care; Process; Provider; Research; Research Design; Research Methodology; Research Personnel; Research Support; Resources; Risk; Science; Services; Statistical Methods; Strategic Planning; Substance Use Disorder; Substance abuse problem; Symptoms; Technology; Testing; Training; Training Programs; Trauma; Underrepresented Populations; United States; Universities; Vulnerable Populations; Washington; Work; antiretroviral therapy; base; collaborative care; comorbidity; disparity reduction; driving force; effective therapy; evidence base; experience; health care delivery; healthcare community; implementation science; innovation; marginalized population; mortality; multidisciplinary; next generation; novel; person centered; psychologic; scale up; social science research; social stigma; socioeconomic disadvantage; theories; therapy development; traumatic stress; treatment strategy; user centered design

OVERALL ABSTRACT The proposed University of Washington (UW) Developmental AIDS Research Center (D-ARC) responds to the global HIV epidemic at a critical stage. Though more than 21 million people around the world receive antiretroviral therapy, the most marginalized populations continue to experience high incidence, less access to effective prevention and care, and greater mortality. Unmet needs persist in high-prevalence countries as well as “geographic hotspots” in the US such as Seattle's King County. Intersecting stigma, trauma, poverty, and substance abuse increase risk for mental illnesses, yet the effective treatments available are rarely implemented. The proposed D-ARC aims to address these challenges by catalyzing research that helps end the epidemic, with a focus on integrating care for mental disorders into HIV prevention and treatment strategies. Furthermore, Center investigators will support and apply the science of dissemination and implementation, with the overall goal of bringing such interventions to scale. The D-ARC aims to fill a gap in HIV behavioral science research at UW by capitalizing on the considerable strengths of UW's HIV expertise and bridging this with UW's longstanding leadership in the development and delivery of models of integrated mental health care. By combining UW expertise in (a) HIV research and (b) mental health care—now siloed geographically, programmatically, and conceptually—the Center will be a synergistic force capable of realizing is mission of Implementing Innovative Impactful Integrated Interventions. The proposed infrastructure capitalizes on the strengths of local expertise and broad ties with global collaborative networks, adding value to UW through the Center's administration, research support, and training missions, buttressed through additional institutional commitments of $762,296. Cross-cutting themes of the D-ARC are (a) leveraging local and global bidirectional pathways to learning and innovation by engaging communities of providers and (b) addressing inequities by testing research solutions that reduce disparities. Four proposed Cores address the Overall specific aims: 1) Catalyze and support innovative and impactful research to curb the HIV epidemic, with a focus on integrated intervention strategies (Administrative Core); 2) Provide needed technical assistance and training on research design, measurement, theory and novel statistical methods relevant to mental health and HIV research (Methods Core); 3) Stimulate practice-based research that promotes effective integrated mental health services in HIV care settings and disseminate findings broadly (Integrated Care Core); and 4) Nurture the Next Generation of diverse, multidisciplinary HIV researchers through training and innovative mentorship of early stage investigators and mentors (Developmental Core).

总体摘要 拟议的华盛顿大学 (UW) 发展性艾滋病研究中心 (D-ARC) 回应了 全球艾滋病疫情正处于关键阶段。尽管全世界有超过 2100 万人接受抗逆转录病毒治疗 治疗方面，最边缘化人群的发病率仍然很高，但获得有效治疗的机会却较少 预防和护理，以及更高的死亡率。高流行率国家和地区仍然存在未满足的需求 美国的“地理热点”，例如西雅图的金县。相互交织的耻辱、创伤、贫困和 药物滥用会增加患精神疾病的风险，但现有的有效治疗方法很少得到实施。 拟议的 D-ARC 旨在通过促进研究来应对这些挑战，从而帮助结束 重点将精神障碍关怀纳入艾滋病防治 策略。此外，中心研究人员将支持和应用传播科学和 实施，总体目标是扩大此类干预措施的规模。 D-ARC 旨在填补空白 利用威斯康星大学艾滋病毒专业知识的巨大优势，在威斯康星大学从事艾滋病毒行为科学研究 并将其与威斯康星大学在开发和交付集成模型方面的长期领导地位联系起来 心理保健。通过结合威斯康星大学在（a）艾滋病毒研究和（b）心理健康保健方面的专业知识（现在是孤立的） 从地理上、程序上和概念上来说——该中心将成为一支能够实现以下目标的协同力量： 的使命是实施创新的、有影响力的综合干预措施。拟议的基础设施利用 凭借当地专业知识的优势以及与全球协作网络的广泛联系，通过以下方式为华盛顿大学增加价值 该中心的管理、研究支持和培训任务，通过额外的机构支持 承诺金额 762,296 美元。 D-ARC 的跨领域主题是 (a) 利用本地和全球双向 通过让提供者社区参与进来来实现学习和创新的途径，以及 (b) 通过以下方式解决不平等问题： 测试减少差异的研究解决方案。拟议的四个核心解决总体具体目标：1) 促进和支持创新和有影响力的研究，以遏制艾滋病毒流行，重点是综合研究 干预策略（行政核心）； 2）提供所需的技术援助和研究培训 与心理健康和艾滋病毒研究相关的设计、测量、理论和新颖的统计方法（方法 核）; 3) 促进基于实践的研究，促进有效的艾滋病毒综合心理健康服务 护理环境并广泛传播研究结果（综合护理核心）； 4) 培养下一代 通过对早期研究人员的培训和创新指导，培养多元化、多学科的艾滋病毒研究人员 和导师（发展核心）。