Ophthalmic Therapeutics Engineering Core

眼科治疗工程核心

• 批准号: 10714514
• 负责人: Qifa Zhou
• 金额: $ 20.4万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714514
• 关键词: Acceleration; Anterior; Basic Science; Biological; Biological Products; Cellular biology; Center Core Grants; Chemicals; Computers and Advanced Instrumentation; Consultations; Coupled; Custom; Development; Devices; Drug Delivery Systems; Engineering; Experimental Designs; Eye; Eye diseases; Formulation; Mechanics; Microfabrication; Molecular; Ocular Physiology; Pharmaceutical Preparations; Play; Procedures; Research; Research Personnel; Research Project Grants; Resources; Role; Services; Site; Structure; Technical Expertise; Techniques; Technology; Therapeutic; Vision research; delivery vehicle; design; elastography; improved; innovation; innovative technologies; instrument; instrumentation; investigator training; mechanical device; nanoassembly; nanomedicine; novel; novel therapeutic intervention; novel therapeutics; operation; programs; targeted delivery; technology research and development; translational scientist; ultrasound; vision science

PROJECT SUMMARY: OPHTHALMIC THERAPEUTICS ENGINEERING CORE The Ophthalmic Therapeutics Engineering Core will provide essential resources to facilitate translational vision science and technology research for development of new therapies for ocular diseases. The Core will support instrumentation and technical expertise in molecular engineering required to characterize molecular nano- assemblies designed to carry drugs coupled with expertise in device engineering for their targeted delivery or direct therapeutic applications. The availability of shared and centralized resources accelerates the development of new therapeutic approaches to efficiently and effectively deliver therapies precisely to specific sites in the eye, using innovative technologies. The integrated resources of the Core will play an essential role in bridging basic science, engineering, and translational vision research for developing novel ocular therapeutic approaches. The specific aims are to provide instrumentation and technical expertise for: 1) developing, characterizing and optimizing biological, chemical, or mechanical drug delivery systems; 2) assisting in development of custom devices and instruments that can improve or advance experimental procedures and research capabilities of investigators, particularly those involving delivery of therapeutics; 3) training investigators on the utility and operation of available instrumentation for the design and characterization of therapeutic drug delivery vehicles and devices; and 4) consultations on the experimental design, appropriateness of the specific techniques, and integration of engineering techniques to escalate the progress of vision research projects.

项目摘要：眼科治疗工程核心 眼科治疗工程核心将提供必要的资源来促进转化性视力 为开发眼科疾病的新疗法进行科学技术研究。核心将支持 分子工程所需的仪器和技术专长，以表征分子纳米 为携带药物而设计的组件，加上设备工程方面的专业知识，以实现其靶向传递或 直接治疗应用。共享和集中资源的可用性加速了 开发新的治疗方法，以高效、有效地将治疗精确地输送到特定的 网站在眼睛里，使用创新技术。核心的综合资源将发挥至关重要的作用 在基础科学、工程学和转化性视觉研究之间建立桥梁，以开发新的眼科治疗方法 接近了。其具体目标是为以下方面提供仪器和技术专业知识：1)开发、 表征和优化生物、化学或机械给药系统；2)协助 开发定制的设备和仪器，以改进或改进实验程序和 研究人员的研究能力，特别是涉及提供治疗的能力；3)培训 关于可用于设计和表征的仪器的效用和操作的调查人员 治疗性药物输送载体和装置；4)试验设计咨询， 具体技术的适当性，以及工程技术的集成以提升进度 视觉研究项目。