Ophthalmic Therapeutics Engineering Core

眼科治疗工程核心

• 批准号: 10714514
• 负责人: Qifa Zhou
• 金额: $ 20.4万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714514
• 关键词: Acceleration; Anterior; Basic Science; Biological; Biological Products; Cellular biology; Center Core Grants; Chemicals; Computers and Advanced Instrumentation; Consultations; Coupled; Custom; Development; Devices; Drug Delivery Systems; Engineering; Experimental Designs; Eye; Eye diseases; Formulation; Mechanics; Microfabrication; Molecular; Ocular Physiology; Pharmaceutical Preparations; Play; Procedures; Research; Research Personnel; Research Project Grants; Resources; Role; Services; Site; Structure; Technical Expertise; Techniques; Technology; Therapeutic; Vision research; delivery vehicle; design; elastography; improved; innovation; innovative technologies; instrument; instrumentation; investigator training; mechanical device; nanoassembly; nanomedicine; novel; novel therapeutic intervention; novel therapeutics; operation; programs; targeted delivery; technology research and development; translational scientist; ultrasound; vision science

PROJECT SUMMARY: OPHTHALMIC THERAPEUTICS ENGINEERING CORE The Ophthalmic Therapeutics Engineering Core will provide essential resources to facilitate translational vision science and technology research for development of new therapies for ocular diseases. The Core will support instrumentation and technical expertise in molecular engineering required to characterize molecular nano- assemblies designed to carry drugs coupled with expertise in device engineering for their targeted delivery or direct therapeutic applications. The availability of shared and centralized resources accelerates the development of new therapeutic approaches to efficiently and effectively deliver therapies precisely to specific sites in the eye, using innovative technologies. The integrated resources of the Core will play an essential role in bridging basic science, engineering, and translational vision research for developing novel ocular therapeutic approaches. The specific aims are to provide instrumentation and technical expertise for: 1) developing, characterizing and optimizing biological, chemical, or mechanical drug delivery systems; 2) assisting in development of custom devices and instruments that can improve or advance experimental procedures and research capabilities of investigators, particularly those involving delivery of therapeutics; 3) training investigators on the utility and operation of available instrumentation for the design and characterization of therapeutic drug delivery vehicles and devices; and 4) consultations on the experimental design, appropriateness of the specific techniques, and integration of engineering techniques to escalate the progress of vision research projects.

项目总结：眼科治疗工程核心 眼科治疗工程核心将提供必要的资源，以促进平移视觉 科学和技术研究，以开发新的眼科疾病治疗方法。核心将支持 表征分子纳米结构所需的分子工程仪器和技术专长， 设计用于携带药物的组件，加上针对其靶向递送的设备工程专业知识， 直接的治疗应用。共享和集中资源的可用性加快了 开发新的治疗方法，以高效和有效地将治疗精确地提供给特定的 网站的眼睛，使用创新技术。核心的综合资源将发挥重要作用 在基础科学、工程学和转化视觉研究之间建立桥梁，以开发新的眼部治疗方法。 接近。具体目标是提供仪器和技术专长：1）开发， 表征和优化生物、化学或机械药物递送系统; 2）协助 开发定制设备和仪器，可以改善或推进实验程序， 研究者的研究能力，特别是那些涉及提供治疗的研究者; 3）培训 研究人员对现有仪器的实用性和操作的设计和表征 治疗药物递送载体和装置;和4）关于实验设计的咨询， 具体技术的适当性，以及工程技术的集成，以逐步提高进度 视觉研究项目。