2022 Cornea and Ocular Surface Biology, Pathology and Regeneration GRC/GRS

项目摘要 眼表由角膜、结膜、眼皮和与之相关的腺体组成。 用来分泌泪膜。这些结构中的任何一个的发育不全或动态平衡的破坏都可能导致 角膜和眼表疾病，可导致失明或失明。了解 眼表组织的发生及其正常功能和疾病或创伤后的修复对于 识别疾病相关基因和新药，这些基因和新药可能会带来必不可少的创新疗法 用来维持视力健康。我们请求支持戈登研究会议和 角膜和眼表面生物学、病理学和再生(GRC-COSBPR)，2022年2月13-18日，在 加州文图拉海滩万豪酒店。2022年GRC-COSBPR的目标是将国际社会聚集在一起 并为最新、最前沿的基础、翻译和临床研究提供论坛 重点是加快将调查结果从长凳上翻译到床边。建立在来自 在过去的六次会议中，我们计划举行9次科学会议，讨论眼表生物学中的关键范式转换创新， 病理学和组织修复。研讨会的题目是：1.数据采集和分析的新方法；2. 细胞相互作用、细胞外基质和形态发生；3.基因组学和基因调控； 角膜和眼表创伤修复的研究进展5.眼表疾病的发病机制 疾病；6.眼表干细胞；7.眼表炎症和再生；8. 角膜和眼表的疾病与健康；9.眼表研究的小说翻译 治疗。我们正在组织一个多样化的、性别平衡的会议，邀请来自北方和拉丁语的演讲者参加 美国、英国、以色列、亚洲(日本、印度、中国)和澳大利亚。我们将特别强调 通过邀请妇女和代表性不足的少数群体来增加多样性。每期会议将由一位 早期的职业科学家与一位知名的研究人员结成了伙伴。会议将包括延长的时间 讨论。每个会议的一部分未承诺从提交的摘要中选择发言者，特别是 职业生涯早期的调查员。GRC会议将包括一个“权力小时”，讨论挑战女性和 代表不足的少数群体在科学领域面临着多样性和包容性的问题。2022年GRC将是 在此之前，第五届为期两天的戈登研究研讨会(GRS)由敬业的学生和博士后领导。这个 GRS为年轻科学家提供了一个在非恐吓环境中展示他们的研究的机会， 得到了几位资深科学家的支持和反馈。GRS会议的开始促进了社区建设 和长期的关系。2022年GRC-COSBPR会议将由GRC和该计划进行宣传 更新将发布在网站上，并通过Twitter和Facebook等社交媒体发布，以提高知名度 在初级科学家和实习生中。我们相信我们的计划与NEI及其 支持将使我们能够提供高质量和成功的会议。

Project Summary The ocular surface is comprised of the cornea, conjunctiva, eyelids and associated glands that are responsible for secretion of the tear film. Dysgenesis or disruption of the homeostasis of any of these structures can lead to corneal and ocular surface diseases, which can result in loss of eyesight or cause blindness. Understanding the genesis of the ocular surface tissues, and its normal function and repair after disease or trauma, is crucial for identifying disease-associated genes and novel drugs that may lead to innovative therapies that are essential for maintaining visual health. We request support for the Gordon Research Conference and Seminar of the Cornea and Ocular Surface Biology, Pathology and Regeneration (GRC-COSBPR), February 13-18, 2022, at Ventura Beach Marriott in California. The goal of the 2022 GRC-COSBPR is to bring together international leaders in the field and provide a forum for the most recent, cutting-edge basic, translational and clinical research focused on expediting translation of findings from bench to bedside. Building on the strong track record from the past six meetings, we plan 9 scientific sessions on key paradigm shifting innovations in ocular surface biology, pathology, and tissue repair. The session titles are: 1. Novel Approaches to Data Acquisition and Analysis; 2. Cellular Interactions, the Extracellular Matrix, and Morphogenesis; 3. Genomics and Gene Regulation; 4. Advances in Cornea and Ocular Surface Wound Repair; 5. Mechanisms of Ocular Surface Disease and Disorders; 6. Stem cells of the Ocular Surface; 7. Inflammation and Regeneration of the Ocular Surface; 8. Sickness and Health of the Cornea and Ocular Surface; 9. Translation of Ocular Surface Research into Novel Therapies. We are organizing a diverse, gender-balanced meeting with speakers invited from North and Latin America, United Kingdom, Israel, Asia (Japan, India, China), and Australia. Special emphasis will be given to increase diversity by inviting women and underrepresented minorities. Each session will be co-moderated by an early career scientist paired with an established researcher. The sessions will include extended time for discussions. A portion of each session is uncommitted to select speakers from submitted abstracts, particularly early career investigators. The GRC conference will include a “Power Hour” to discuss challenges women and underrepresented minorities face in science and issues of diversity and inclusion. The 2022 GRC will be preceded by the 5th two-day Gordon Research Seminar (GRS) led by dedicated students and post-docs. The GRS provides an opportunity for young scientists to present their research in a non-intimidating environment, with support and feedback from a few senior scientists. The GRS start of the meeting fosters community building and long term relationships. The 2022 GRC-COSBPR meeting will be advertised by the GRC and the program updates will be posted on the website and via social media such as Twitter and Facebook to increase visibility among junior scientists and trainees. We believe our program is aligned with the scientific goals of NEI and its support will enable us to provide a high quality and successful meeting.