2022 Bones and Teeth Gordon Research Conference and Seminar

摘要/摘要 骨骼是由许多组织组成的器官，具有各种基本和重要的功能。 在过去的几年里，越来越清楚的是，新陈代谢途径和局部环境 在骨骼的生物学中起着至关重要的作用。这些新的发展正在开辟令人兴奋的道路 用于研究。它们还可能为骨质疏松等破坏性疾病带来新的治疗方法， 骨质疏松症、骨癌和骨骼遗传性疾病，以及全身病理， 包括生物能量代谢的失调。我们大会的主题是“新陈代谢和 在骨骼发育、疾病和再生方面的当地环境“。在这方面取得了重大进展 了解形成骨并在修复过程中保持其完整性的细胞之间的局部通讯 生物体的寿命将被展示出来。同样，骨细胞与其他组织的相互作用 构成骨骼，即血管、造血骨髓、骨髓脂肪、骨髓 间质和肌腱将被检查。最后，骨骼内的分子和细胞机制 将讨论整合局部相互作用、生物能量学新陈代谢和生物机械力的生物力学。 会议的总体目标是鼓励对新的研究方向和新奇事物的追求 治疗方法，以及促进顶尖实验室之间的高效合作 菲尔德。基于在之前的B&T GRCS之前成功举办的戈登研究研讨会(GRS) 多年来，GRC组织已经批准了与2022年B&T GRC相关的GRS。2022年的B&T 由肖尼·卢普曼斯和克莱尔·阿拉塔组织的GRS将被称为“从长凳到床边： 了解开发疗法的基本原理“，并将更多地关注 了解骨骼中的代谢需求和环境因素，以便将其转化为 治疗。GRS将推出一个导师计划，为早期阶段的科学家提供指导 职业发展。今年，导师制将被称为“成功的路线图” 在学术界“。主办方将从提交的摘要中选择演讲，并鼓励所有与会者 赠送海报，并留下来参加下一届GRC。根据以往的经验，年轻的科学家 对GRS的参与感到兴奋，在GRC保持高度参与。

Summary/Abstract The skeleton is an organ composed of many tissues and with a variety of fundamental and vital functions. In the last few years, it has become increasingly clear that the metabolic pathways and local environments have a crucial role in the biology of the skeleton. Those new developments are opening exciting avenues for research. They may also lead to novel treatments of devastating conditions such as osteoporosis, osteopetrosis, bone cancer, and genetic disorders of the skeleton, as well as systemic pathologies, including the dysregulation of bioenergetic metabolism. The theme of our conference is “Metabolism and local environments in development, disease and regeneration of the skeleton”. Significant progress in the understanding of local communication among cells that form bone and maintain its integrity during the lifespan of the organism will be presented. Likewise, the interactions of bone cells with the other tissues constituting the skeleton, namely blood vessels, hematopoietic marrow, bone marrow fat, bone marrow stroma, and tendons will be examined. Lastly, the molecular and cellular mechanisms within the skeleton that integrate local interactions, bioenergetics metabolism and biomechanical forces will be discussed. The overall goal of the conference is to encourage the pursuit of new research directions and novel therapeutic approaches, as well as foster highly productive collaborations among top laboratories in the field. Based on the successful Gordon Research Seminar (GRS) that preceded the B&T GRCs in previous years, the GRC organization has approved a GRS associated with the 2022 B&T GRC. The 2022 B&T GRS, organized by Shauni Loopmans and Claire Arata, will be called "From bench-to-bedside: understanding the skeleton for developing therapies" and will focus more on the importance of understanding metabolic requirements and environmental factors in the bone for its translation toward therapies. GRS will feature a mentorship program that provides guidance to early-stage scientists on career development. This year, the mentorship component will be called “A roadmap to being successful in academia”. The organizers will select talks from submitted abstracts, and all attendees are encouraged to present posters and stay for the subsequent GRC. Based on the previous experiences, young scientists excited by GRS participation remain highly engaged at the GRC.