Estimating the risk for and severity of respiratory infections attributable to CFTR heterozygosity
评估 CFTR 杂合性引起的呼吸道感染的风险和严重程度
基本信息
- 批准号:10377955
- 负责人:
- 金额:$ 73.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAfrican American populationAgeAreaAspergillosisAsthmaBicarbonatesBiologicalBiological AssayBronchiectasisBronchitisCarrier StateCaucasiansCell Culture TechniquesCharacteristicsChloridesClinical DataCodeCommunicable DiseasesComputerized Medical RecordCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDNA Sequence AlterationDataData SetDiabetes MellitusDiagnosisDiseaseEpidemiologyEpithelialEpithelial CellsFrequenciesFutureGastrointestinal DiseasesGene MutationGeneral PopulationGenesGenetic CounselingGenetic DiseasesGenotypeGoalsHealthHeterozygoteHospitalizationHumanIndividualInfectionInterventionInvestigationLength of StayLongitudinal cohortMedical RecordsMethodsMissionModelingMorbidity - disease rateMutationMycobacterium InfectionsNational Institute of Allergy and Infectious DiseaseNatural HistoryOutcomePancreatitisPatientsPersonsPharmaceutical PreparationsPharmacologyPneumoniaPopulationProceduresRecurrenceRegulator GenesResearchRespiratory Tract InfectionsRiskRisk EstimateRoleSeveritiesSinusitisSurfaceTestingUnited StatesWorkairway epitheliumantimicrobialcohortcost effective treatmentcystic fibrosis infectioncystic fibrosis patientsdesigndisorder riskelectronic datagenetic testinghigh riskinjured airwayinnovationmortalitypopulation basedpreventreadmission ratesrecessive genetic traitrecurrent infectionrespiratorysex
项目摘要
Project Summary/Abstract
1 Cystic fibrosis is one of the most common autosomal regressive genetic disorders in the United States:
2 approximately 1 out of 32 Caucasians and 1 out of 61 African Americans is a CF carrier. A hallmark of this
3 disease is recurrent respiratory infections. However, cystic fibrosis requires two copies of the CFTR
4 mutation. Traditionally, one non-mutated CFTR gene was thought to be sufficient for maintaining health.
5 However, a few small studies and preliminary work by our group have demonstrated that CF carriers may
6 be at increased risk for respiratory infections, including recurrent sinusitis, pneumonia, and atypical
7 mycobacterial infections, than non-CF carriers. Given an estimated population of 15 million CF carriers in
8 the United States, if carriers are more likely to acquire respiratory infections, the attributable burden of
9 respiratory infections and corresponding antimicrobial use attributable to the CF-carrier state may be
10 substantial. Thus, there is a critical need for population-based investigations to precisely determine the
11 attributable risk of the CF-carrier state for respiratory infections.
12 The goal of our research is to determine the role of the CF-carrier state on the risk for acquiring respiratory
13 infections. Due to the frequency of genetic testing for CFTR mutations for genetic counseling, it is possible
14 to identify CF carriers in some existing population-based data sets. Our group has recently demonstrated
15 that CF carriers are at significantly greater risk for respiratory infections compared to age and sex matched
16 controls. However, more work is needed that considers other patient characteristics as well as patients'
17 specific CF mutations. In addition, the biological plausibility of these findings needs to be established. Thus,
18 we will determine the natural history of respiratory infections for CF carriers using administrative claims
19 data; determine the risk for respiratory infections among CF carriers in a genotyped cohort using data from
20 electronic medical records, and assess airway epithelial function in CF carriers compared to non-carriers.
21 This work is significant because respiratory infections are a major cause of morbidity and mortality; CF
22 carriers are common and can be identified by current genetic counseling methods; and there are CFTR-
23 modulating therapies available that may be cost-effective treatments for CF carriers with excessive
24 respiratory infections. This work is innovative because all previous work in this area has been done using
25 small cohorts of patients, and we will have access to a large cohort of CF carriers and controls. Also, we will
26 be able to identify the CF carriers using diagnosis and procedure codes in administrative data and the
27 medical record an in one cohort we will be able to identify specific CFTR mutations.
28 Given the number of CF carriers in the general population, the methods and models we develop will have
29 broad implications for other diseases beyond respiratory infections.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PHILIP M. POLGREEN其他文献
PHILIP M. POLGREEN的其他文献
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{{ truncateString('PHILIP M. POLGREEN', 18)}}的其他基金
Estimating the risk for and severity of respiratory infections attributable to CFTR heterozygosity
评估 CFTR 杂合性引起的呼吸道感染的风险和严重程度
- 批准号:
10593092 - 财政年份:2021
- 资助金额:
$ 73.1万 - 项目类别:
Contact Network Transmission Modeling of Healthcare Associated Infections
医疗保健相关感染的接触网络传播模型
- 批准号:
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$ 73.1万 - 项目类别:
Contact Network Transmission Modeling of Healthcare Associated Infections
医疗保健相关感染的接触网络传播模型
- 批准号:
10669687 - 财政年份:2020
- 资助金额:
$ 73.1万 - 项目类别:
Determining the acceptability and feasibility of mobile-health approaches to gather clinical information from patients at home following hospital discharge
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- 批准号:
10238144 - 财政年份:2020
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$ 73.1万 - 项目类别:
Determining the acceptability and feasibility of mobile-health approaches to gather clinical information from patients at home following hospital discharge
确定移动医疗方法在出院后在家中收集患者临床信息的可接受性和可行性
- 批准号:
10052922 - 财政年份:2020
- 资助金额:
$ 73.1万 - 项目类别:
Contact Network Transmission Modeling of Healthcare Associated Infections
医疗保健相关感染的接触网络传播模型
- 批准号:
10241230 - 财政年份:2020
- 资助金额:
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An mHealth Intervention to Increase Activity Among Patients at Risk for Type 2 Diabetes
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美国传染病学会新发感染网络 (IDSA EIN)
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8299384 - 财政年份:2011
- 资助金额:
$ 73.1万 - 项目类别:
THE INFECTIOUS DISEASES SOCIETY OF AMERICA EMERGING INFECTIONS NETWORK (IDSA EIN)
美国传染病学会新发感染网络 (IDSA EIN)
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8502173 - 财政年份:2011
- 资助金额:
$ 73.1万 - 项目类别:
THE INFECTIOUS DISEASES SOCIETY OF AMERICA EMERGING INFECTIONS NETWORK (IDSA EIN)
美国传染病学会新发感染网络 (IDSA EIN)
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8258902 - 财政年份:2011
- 资助金额:
$ 73.1万 - 项目类别:
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